公开(公告)号：US20220098196A1

公开(公告)日：2022-03-31

申请号：US17428605

申请日：2020-01-31

Applicant: The Board of Regents of the University of Texas System

Inventor： Yonghao YU ,  Chuo CHEN ,  Shuai WANG ,  Lei HAN ,  Lin YOU

IPC: C07D471/06 ,  C07D401/14 ,  C07D417/14 ,  C07D487/06 ,  A61K45/06

Abstract: The disclosure provides PARP PROTAC molecules comprising a PARP inhibitor linked to an E3 ligase binder, and their use in treating diseases caused by aberrant PARP activation. Such PROTAC molecules produce selective degradation of one or a specific set of PARP proteins with limited effects on the protein level of other PARPs.

公开(公告)号：US20200308216A1

公开(公告)日：2020-10-01

申请号：US16903173

申请日：2020-06-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Lijun SUN ,  Jiaxi WU ,  Heping SHI ,  Chuo CHEN

IPC: C07H21/02 ,  A61K39/39 ,  C12Q1/6876 ,  C12Q1/25 ,  G01N33/573 ,  A61K31/7084 ,  G01N33/564

Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.

公开(公告)号：US20200010501A1

公开(公告)日：2020-01-09

申请号：US16438153

申请日：2019-06-11

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Heping SHI ,  Yuanwei DAI ,  Qi WEI ,  Chuo CHEN ,  Zhijian CHEN ,  Lijun SUN

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/7084 ,  A61K45/06

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

公开(公告)号：US20140038922A1

公开(公告)日：2014-02-06

申请号：US13875170

申请日：2013-05-01

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Lawrence LUM ,  Michael G. ROTH ,  Baozhi CHEN ,  Chuo CHEN ,  Michael E. DODGE ,  Wei TANG

IPC: C07D209/48 ,  C07D401/10 ,  C07D471/04 ,  C07D401/12 ,  C07D401/14

CPC classification number: A61K31/519 ,  A61K31/502 ,  A61K45/06 ,  C07D209/48 ,  C07D209/94 ,  C07D239/54 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D413/04 ,  C07D417/12 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.

Abstract translation: 本发明一般涉及蛋白信号传导。 特别地，公开了抑制Wnt蛋白信号通路的化合物。 这些化合物可用于治疗Wnt蛋白信号传导相关疾病和病症如癌症，退行性疾病，II型糖尿病和骨细胞减少症。

公开(公告)号：US20240092760A1

公开(公告)日：2024-03-21

申请号：US18334325

申请日：2023-06-13

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jian QIU ,  Qi WEI ,  Matt TSCHANTZ ,  Heping SHI ,  Youtong WU ,  Huiling TAN ,  Lijun SUN ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/6503 ,  C07F9/6506

CPC classification number: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/65031 ,  C07F9/6506

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20220356158A1

公开(公告)日：2022-11-10

申请号：US17191305

申请日：2021-03-03

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Jing LI ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D277/34 ,  C07D417/14 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20210290774A1

公开(公告)日：2021-09-23

申请号：US17317864

申请日：2021-05-11

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Heping SHI ,  Qi WEI ,  Chuo CHEN ,  Lijun SUN ,  Jian QIU ,  Youtong WU

IPC: A61K47/68 ,  A61P35/00

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

公开(公告)号：US20190202804A1

公开(公告)日：2019-07-04

申请号：US16330050

申请日：2017-08-31

Applicant: The Board of Regents of the University of Texas System

Inventor： Nageswari YARRAVARAPU ,  Chuo CHEN ,  Lawrence LUM ,  Lin YOU ,  Chengwei ZHANG ,  Xiaolei WANG ,  Lishu ZHANG

IPC: C07D401/12 ,  C07D401/14 ,  C07D255/02

CPC classification number: C07D401/12 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06 ,  C07D255/02 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit the Wnt pathway and used to treat cancer, myocardial infarction, osteopetrosis, or used in the maturation of a precursor cell to a mature cell. Also provided herein in are pharmaceutical compositions of the compounds described herein.

公开(公告)号：US20180271848A1

公开(公告)日：2018-09-27

申请号：US15571240

申请日：2016-05-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Lawrence LUM ,  Chuo CHEN ,  Xuewu ZHANG ,  Ozlem KULAK ,  Xiaofeng WU

IPC: A61K31/454 ,  A61K45/06

Abstract: The present disclosure provides compounds that may be useful for inhibiting the Tankyrase enzyme. In some aspects, these compounds are useful in the treatment of a disease or disorder related to the misregulation of Tankyrase enzyme such as cancer, degenerative diseases, or fibrotic diseases. Also provided herein are compounds may also be used to prevent the elongation of the telomere in a cell.

公开(公告)号：US20170304240A1

公开(公告)日：2017-10-26

申请号：US15312790

申请日：2015-05-12

Applicant: The Board of Regents of the University of texas System

Inventor： Chengcheng ZHANG ,  Yi LIU ,  Junke ZHENG ,  Mi DENG ,  Chuo CHEN ,  Jiawei LIU

IPC: A61K31/194 ,  C12N5/078 ,  A61K31/155 ,  A61K31/20 ,  A61K31/197 ,  C12N5/0789 ,  A61K45/06 ,  C07C279/14

CPC classification number: A61K31/194 ,  A61K31/155 ,  A61K31/197 ,  A61K31/20 ,  A61K45/06 ,  C07C279/14 ,  C12N5/0634 ,  C12N5/0647

Abstract: The present disclosure relates to methods of using a compound to induce regeneration of hematopoietic stem cells or increase the recovery of red blood cells. In some aspects, the present methods can be used to with or in place of erythropoietin in patients to mitigate the side effects of erythropoietin.