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公开(公告)号:US20230037361A1
公开(公告)日:2023-02-09
申请号:US17969990
申请日:2022-10-20
摘要: A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.
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公开(公告)号:US11504303B2
公开(公告)日:2022-11-22
申请号:US17557483
申请日:2021-12-21
摘要: A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.
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公开(公告)号:US20210353829A1
公开(公告)日:2021-11-18
申请号:US17342409
申请日:2021-06-08
发明人: Ali Khademhosseini , Nasim Annabi , Reza Dana , Ahmad Kheirkhah
摘要: The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.
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公开(公告)号:US20210213181A1
公开(公告)日:2021-07-15
申请号:US17058224
申请日:2019-05-29
发明人: Ali Khademhosseini , Guillermo Ulises Ruiz Esparza Herrera , Xichi Wang , Su Ryon Shin , Thomas Jozefiak
摘要: The present application relates to shear thinning hydrogel compositions which are useful for reducing and/or preventing tissue adhesion in a subject (e.g., a post-operative subject). Methods of using the compositions and kits comprising the compositions oar also provided.
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公开(公告)号:US20200306143A1
公开(公告)日:2020-10-01
申请号:US15777304
申请日:2017-12-01
摘要: A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.
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公开(公告)号:US20240269347A1
公开(公告)日:2024-08-15
申请号:US18471748
申请日:2023-09-21
发明人: Ali Khademhosseini , Nasim Annabi , Reza Dana , Ahmad Kheirkhah
CPC分类号: A61L27/3804 , A61L27/222 , A61L27/3839 , A61L27/52 , A61P27/02 , A61L2430/16
摘要: The present disclosure provides compositions and methods for repair and reconstruction of defects and injuries to the cornea. For example, the present disclosure provides a composition for corneal reconstruction including a methacryloyl-substituted gelatin, a visible light-activated photoinitiator, and a pharmaceutically acceptable carrier. In another example, the present disclosure provides a method for corneal reconstruction including the steps of: applying a composition and exposing the composition to visible light.
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公开(公告)号:US11058800B2
公开(公告)日:2021-07-13
申请号:US16070643
申请日:2017-02-08
发明人: Ali Khademhosseini , Nasim Annabi , Reza Dana , Ahmad Kheirkhah
摘要: The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.
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公开(公告)号:US10723783B2
公开(公告)日:2020-07-28
申请号:US15559481
申请日:2016-03-18
发明人: Nasim Annabi , Ali Khademhosseini
IPC分类号: A61K38/16 , C07K14/78 , A61L24/10 , A61L26/00 , A61L24/00 , A61L27/22 , A61L27/52 , A61L27/54
摘要: Disclosed herein are polypeptides comprising an amino acid sequence of {[VPGVG]4IPGVG}n, wherein n is an integer greater than 1. The polypeptides can be crosslinked to from biocompatible hydrogels with tunable and desirable mechanical properties. The polypeptides and hydrogels can be used in a variety of biomedical applications including treatment of bleeding, treatment of soft tissue injury, injectable filler, and tissue adhesives.
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