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公开(公告)号：US12007687B2
公开(公告)日：2024-06-11
申请号：US18324452
申请日：2023-05-26
IPC分类号： B29C64/00 , B22F10/00 , B22F10/85 , B22F12/00 , B22F12/82 , B29C64/10 , B29C64/106 , B29C64/176 , B29C64/182 , B29C64/20 , B29C64/205 , B29C64/227 , B29C64/245 , B29C64/25 , B29C64/255 , B29C64/30 , B29C64/307 , B29C64/386 , B29C64/393 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y40/10 , B33Y40/20 , B33Y50/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , B33Y99/00 , G03F7/00
CPC分类号： G03F7/001 , B22F10/00 , B22F10/85 , B22F12/00 , B22F12/82 , B29C64/00 , B29C64/10 , B29C64/106 , B29C64/176 , B29C64/182 , B29C64/20 , B29C64/205 , B29C64/227 , B29C64/245 , B29C64/25 , B29C64/255 , B29C64/30 , B29C64/307 , B29C64/386 , B29C64/393 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y40/10 , B33Y40/20 , B33Y50/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , B33Y99/00 , G03F7/00
摘要： Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.
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公开(公告)号：US20230359117A1
公开(公告)日：2023-11-09
申请号：US18324452
申请日：2023-05-26
IPC分类号： G03F7/00 , B33Y80/00 , B29C64/106 , B33Y70/00 , B29C64/00 , B29C64/205 , B29C64/386 , B33Y40/20 , B29C64/176 , B33Y10/00 , B33Y40/10 , B29C64/245 , B29C64/25 , B33Y50/00 , B29C64/40 , B22F12/00 , B29C64/393 , B29C64/227 , B33Y40/00 , B22F10/00 , B29C64/255 , B33Y50/02 , B22F10/85 , B29C64/20 , B29C64/10 , B33Y30/00 , B29C64/30 , B29C64/307 , B33Y99/00 , B29C64/182 , B22F12/82
CPC分类号： G03F7/001 , B33Y80/00 , B29C64/106 , B33Y70/00 , B29C64/00 , G03F7/00 , B29C64/205 , B29C64/386 , B33Y40/20 , B29C64/176 , B33Y10/00 , B33Y40/10 , B29C64/245 , B29C64/25 , B33Y50/00 , B29C64/40 , B22F12/00 , B29C64/393 , B29C64/227 , B33Y40/00 , B22F10/00 , B29C64/255 , B33Y50/02 , B22F10/85 , B29C64/20 , B29C64/10 , B33Y30/00 , B29C64/30 , B29C64/307 , B33Y99/00 , B29C64/182 , B22F12/82
摘要： Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.
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公开(公告)号：US10814032B2
公开(公告)日：2020-10-27
申请号：US15502347
申请日：2015-08-06
IPC分类号： A61L24/10 , A61L24/00 , A61K31/137
摘要： The present invention provides an improved tissue adhesive to repair defects in soft tissue. Following ASTM standard tests, crosslinked methacryloyl-substituted gelatin hydrogels of the present invention (GelSEAL) were shown to exhibit adhesive properties, i.e. wound closure strength, shear resistance and burst pressure, that were superior to clinically used fibrin- and poly(ethylene glycol)-based glues. Chronic in vivo experiments in rats proved GelSEAL to effectively seal large lung leakages without additional sutures or staples, presenting improved performance as compared to fibrin and poly(ethylene glycol) glues. Furthermore, subcutaneous implantation in rats revealed high biocompatibility of GelSEAL as evidenced by low inflammatory host response. Advantageously, the tissue adhesives of the present invention are low cost and easy to produce, making them a promising substance to be used as a sealant for fluid leakages in soft tissue, as well as an easily tunable platform to further optimize the adhesive characteristics.
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公开(公告)号：US12103173B2
公开(公告)日：2024-10-01
申请号：US16091193
申请日：2017-04-20
IPC分类号： B25J9/04 , A61L27/36 , B25J9/02 , B25J9/16 , B29C64/141 , B29C64/209 , B29C64/379 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00
CPC分类号： B25J9/045 , A61L27/36 , B25J9/023 , B25J9/16 , B29C64/141 , B29C64/209 , B29C64/379 , B33Y70/00 , B33Y10/00 , B33Y30/00 , B33Y80/00
摘要： Described are systems and methods for in vivo multi-material bioprinting. The in vivo multi-material bioprinting can be used to fabricate biomedical constructs within a patient minimally invasively. The systems and methods can utilize a multi-material bioprinter, which includes a biocompatible portion. The biocompatible portion can include a single printhead for in vivo bioprinting. The single printhead can include a plurality of outlets, each linked to one of a plurality of reservoirs. Each of the plurality of reservoirs can each house a different bioink for bioprinting. Each of the plurality of outlets can be activated to release a respective bioink.
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公开(公告)号：US20220110836A1
公开(公告)日：2022-04-14
申请号：US17557483
申请日：2021-12-21
摘要： A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.
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公开(公告)号：US12090246B2
公开(公告)日：2024-09-17
申请号：US17064390
申请日：2020-10-06
IPC分类号： A61L24/10 , A61K31/137 , A61L15/32 , A61L24/00 , A61L31/04
CPC分类号： A61L24/104 , A61K31/137 , A61L24/001 , A61L24/0015 , A61L24/0031 , A61L2300/104 , A61L2300/404 , A61L2300/418 , A61L2400/04
摘要： The present invention provides an improved tissue adhesive to repair defects in soft tissue. Following ASTM standard tests, crosslinked methacryloyl-substituted gelatin hydrogels of the present invention (GelSEAL) were shown to exhibit adhesive properties, i.e. wound closure strength, shear resistance and burst pressure, that were superior to clinically used fibrin- and poly(ethylene glycol)-based glues. Chronic in vivo experiments in rats proved GelSEAL to effectively seal large lung leakages without additional sutures or staples, presenting improved performance as compared to fibrin and poly(ethylene glycol) glues. Furthermore, subcutaneous implantation in rats revealed high biocompatibility of GelSEAL as evidenced by low inflammatory host response. Advantageously, the tissue adhesives of the present invention are low cost and easy to produce, making them a promising substance to be used as a sealant for fluid leakages in soft tissue, as well as an easily tunable platform to further optimize the adhesive characteristics.
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公开(公告)号：US12016938B2
公开(公告)日：2024-06-25
申请号：US17969990
申请日：2022-10-20
摘要： A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.
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公开(公告)号：US11693311B2
公开(公告)日：2023-07-04
申请号：US16660956
申请日：2019-10-23
IPC分类号： B29C64/00 , G03F7/00 , B33Y80/00 , B29C64/106 , B33Y70/00 , B29C64/205 , B29C64/386 , B33Y40/20 , B29C64/176 , B33Y10/00 , B33Y40/10 , B29C64/245 , B29C64/25 , B33Y50/00 , B29C64/40 , B22F12/00 , B29C64/393 , B29C64/227 , B33Y40/00 , B22F10/00 , B29C64/255 , B33Y50/02 , B22F10/85 , B29C64/20 , B29C64/10 , B33Y30/00 , B29C64/30 , B29C64/307 , B33Y99/00 , B29C64/182 , B22F12/82
CPC分类号： G03F7/001 , B22F10/00 , B22F10/85 , B22F12/00 , B22F12/82 , B29C64/00 , B29C64/10 , B29C64/106 , B29C64/176 , B29C64/182 , B29C64/20 , B29C64/205 , B29C64/227 , B29C64/245 , B29C64/25 , B29C64/255 , B29C64/30 , B29C64/307 , B29C64/386 , B29C64/393 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y40/10 , B33Y40/20 , B33Y50/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , B33Y99/00 , G03F7/00
摘要： Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.
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公开(公告)号：US11278474B2
公开(公告)日：2022-03-22
申请号：US15777304
申请日：2017-12-01
摘要： A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.
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公开(公告)号：US20200324469A1
公开(公告)日：2020-10-15
申请号：US16091193
申请日：2017-04-20
IPC分类号： B29C64/171 , B29C64/141 , B29C64/209 , B29C64/379 , B25J9/16 , B25J9/02 , B25J9/04 , A61L27/36
摘要： Described are systems and methods for in vivo multi-material bioprinting. The in vivo multi-material bioprinting can be used to fabricate biomedical constructs within a patient minimally invasively. The systems and methods can utilize a multi-material bioprinter, which includes a biocompatible portion. The biocompatible portion can include a single printhead for in vivo bioprinting. The single printhead can include a plurality of outlets, each linked to one of a plurality of reservoirs. Each of the plurality of reservoirs can each house a different bioink for bioprinting. Each of the plurality of outlets can be activated to release a respective bioink.
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