公开(公告)号：US09320916B2

公开(公告)日：2016-04-26

申请号：US13619509

申请日：2012-09-14

申请人： Thilaka Sumanaweera ,  Ed Gardner ,  Oliver Blanck ,  Tao Cai ,  Darrin Uecker ,  Patrick Maguire

发明人： Thilaka Sumanaweera ,  Ed Gardner ,  Oliver Blanck ,  Tao Cai ,  Darrin Uecker ,  Patrick Maguire

IPC分类号： A61N5/10 ,  A61B5/042 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00 ,  A61B8/08 ,  A61B19/00

CPC分类号： A61N5/1037 ,  A61B5/0422 ,  A61B5/7207 ,  A61B5/7289 ,  A61B6/03 ,  A61B6/037 ,  A61B6/503 ,  A61B6/504 ,  A61B8/0883 ,  A61B8/0891 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1077 ,  A61N2005/1061

摘要： Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.

摘要翻译： 心脏组织的放射外科治疗可以使用心脏导管插入技术使用位于心脏或心脏附近的植入基准来减轻心律失常并治疗其他肿瘤和非肿瘤性疾病。 可以在诊断和植入目标组织的图像之后植入基准。 基准植入可能是在进行放射外科治疗的当天进行的。 适应规划后基准植入的技术可以包括植入的基准位置与治疗计划的对齐，并且活动的基准可以限制旁路成像辐射暴露，同时增强跟踪精度。

公开(公告)号：US08345821B2

公开(公告)日：2013-01-01

申请号：US12900717

申请日：2010-10-08

申请人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner

发明人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner

IPC分类号： G21K5/10

CPC分类号： A61N5/1067 ,  A61B5/0402 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5235 ,  A61B6/5294 ,  A61N5/1031 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1068 ,  A61N5/1077 ,  A61N2005/1061

摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.

摘要翻译： 公开了用于在心脏内辐射移动目标的方法和系统。 该方法包括获取心脏区域的顺序体积表示，并且针对第一表示定义3D的目标组织区域和/或辐射敏感结构区域。 通过从第一表示和其他表示的心脏区域的分析来识别目标组织区域和/或辐射敏感结构区域以用于另一个表示。 响应于来自其他表示的识别的目标组织区域和/或辐射敏感结构区域，对目标组织区域的辐射束被点燃。

公开(公告)号：US20110137158A1

公开(公告)日：2011-06-09

申请号：US12900717

申请日：2010-10-08

申请人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner

发明人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner

IPC分类号： A61B6/00

CPC分类号： A61N5/1067 ,  A61B5/0402 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5235 ,  A61B6/5294 ,  A61N5/1031 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1068 ,  A61N5/1077 ,  A61N2005/1061

摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.

摘要翻译： 公开了用于在心脏内辐射移动目标的方法和系统。 该方法包括获取心脏区域的顺序体积表示，并且针对第一表示定义3D的目标组织区域和/或辐射敏感结构区域。 通过从第一表示和其他表示的心脏区域的分析来识别目标组织区域和/或辐射敏感结构区域以用于另一个表示。 响应于来自其他表示的识别的目标组织区域和/或辐射敏感结构区域，对目标组织区域的辐射束被点燃。

公开(公告)号：US09205279B2

公开(公告)日：2015-12-08

申请号：US12838308

申请日：2010-07-16

申请人： Thilaka Sumanaweera ,  Ed Gardner ,  Oliver Blanck ,  Tao Cai ,  Darrin Uecker ,  Patrick Maguire

发明人： Thilaka Sumanaweera ,  Ed Gardner ,  Oliver Blanck ,  Tao Cai ,  Darrin Uecker ,  Patrick Maguire

IPC分类号： A61N5/00 ,  A61N5/10 ,  A61B19/00

CPC分类号： A61N5/1039 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5211 ,  A61B34/10 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61N5/103 ,  G06T15/08 ,  G06T19/20 ,  G06T2210/41

摘要： A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan.

摘要翻译： 生成组织表面的三维模型的系统，例如来自二维图像数据切片的心脏的内表面。 在该表面上，例如由医生使用用户界面绘制一个或多个图案线，以在表面上指定所需的损伤。 从图案线可以使用已知的约束来确定损伤的三维体积。 有利地，由三维体积产生的一系列边界可以被投射回到单独的CT扫描上，然后可以将它们转移到标准的放射外科规划工具。 也可以在模型上投射剂量云以帮助评估计划。

公开(公告)号：US20130102896A1

公开(公告)日：2013-04-25

申请号：US13619064

申请日：2012-09-14

申请人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner

发明人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner

IPC分类号： A61N5/10 ,  A61B6/00 ,  A61B5/0402 ,  A61B6/03

CPC分类号： A61N5/1067 ,  A61B5/0402 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5235 ,  A61B6/5294 ,  A61N5/1031 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1068 ,  A61N5/1077 ,  A61N2005/1061

摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.

公开(公告)号：US20110166407A1

公开(公告)日：2011-07-07

申请号：US12838113

申请日：2010-07-16

申请人： Thilaka Sumanaweera ,  Ed Gardner ,  Oliver Blanck ,  Tao Cai ,  Darrin Uecker ,  Patrick Maguire

发明人： Thilaka Sumanaweera ,  Ed Gardner ,  Oliver Blanck ,  Tao Cai ,  Darrin Uecker ,  Patrick Maguire

IPC分类号： A61B6/00

CPC分类号： A61N5/1037 ,  A61B5/0422 ,  A61B5/7207 ,  A61B5/7289 ,  A61B6/03 ,  A61B6/037 ,  A61B6/503 ,  A61B6/504 ,  A61B8/0883 ,  A61B8/0891 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1077 ,  A61N2005/1061

摘要： Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.

摘要翻译： 心脏组织的放射外科治疗可以使用心脏导管插入技术使用位于心脏或心脏附近的植入基准来减轻心律失常并治疗其他肿瘤和非肿瘤性疾病。 可以在诊断和植入目标组织的图像之后植入基准。 基准植入可能是在进行放射外科治疗的当天进行的。 适应规划后基准植入的技术可以包括植入的基准位置与治疗计划的对齐，并且活动的基准可以限制旁路成像辐射暴露，同时增强跟踪精度。

公开(公告)号：US07953204B2

公开(公告)日：2011-05-31

申请号：US12404881

申请日：2009-03-16

申请人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner ,  Jay West

发明人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner ,  Jay West

IPC分类号： A61N5/10 ,  H05G1/42

CPC分类号： A61N5/1049 ,  A61N5/1037 ,  A61N5/1067 ,  A61N2005/1059 ,  A61N2005/1061

摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.

摘要翻译： 公开了用于在心脏内辐射移动目标的方法和系统。 该方法包括获取心脏区域的顺序体积表示，并且针对第一表示定义3D的目标组织区域和/或辐射敏感结构区域。 通过从第一表示和其他表示的心脏区域的分析来识别目标组织区域和/或辐射敏感结构区域以用于另一个表示。 响应于来自其他表示的识别的目标组织区域和/或辐射敏感结构区域，对目标组织区域的辐射束被点燃。

公开(公告)号：US20080317204A1

公开(公告)日：2008-12-25

申请号：US12077016

申请日：2008-03-14

申请人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner

发明人： Thilaka Sumanaweera ,  Patrick Maguire ,  Ed Gardner

IPC分类号： A61N5/10

CPC分类号： A61N5/1067 ,  A61B5/0402 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5235 ,  A61B6/5294 ,  A61N5/1031 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1068 ,  A61N5/1077 ,  A61N2005/1061

摘要： Method and systems are disclosed for radiating a moving target inside a heart. The method includes acquiring sequential volumetric representations of an area of the heart and defining a target tissue region and/or a radiation sensitive structure region in 3D for a first of the representations. The target tissue region and/or radiation sensitive structure region are identified for another of the representations by an analysis of the area of the heart from the first representation and the other representation. Radiation beams to the target tissue region are fired in response to the identified target tissue region and/or radiation sensitive structure region from the other representation.

摘要翻译： 公开了用于在心脏内辐射移动目标的方法和系统。 该方法包括获取心脏区域的顺序体积表示，并且针对第一表示定义3D的目标组织区域和/或辐射敏感结构区域。 通过从第一表示和其他表示的心脏区域的分析来识别目标组织区域和/或辐射敏感结构区域以用于另一个表示。 响应于来自其他表示的识别的目标组织区域和/或辐射敏感结构区域，对目标组织区域的辐射束被点燃。

公开(公告)号：US20100137709A1

公开(公告)日：2010-06-03

申请号：US12621777

申请日：2009-11-19

申请人： Edward Gardner ,  Thilaka Sumanaweera

发明人： Edward Gardner ,  Thilaka Sumanaweera

IPC分类号： A61B5/05 ,  A61B6/00

CPC分类号： A61B5/04021 ,  A61B5/113 ,  A61B6/583 ,  A61B90/39 ,  A61B2017/00694 ,  A61B2560/0223 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1076 ,  G09B23/286 ,  G09B23/288

摘要： A target motion simulator system for use in verifying target tracking with a radiation therapy device. The system comprises a radiation detection target coupled to a first motion actuator simulating a first motion of a first tissue and a fiducial coupled to a second motion actuator simulating a second motion of a second tissue offset from the first tissue, a component of the first motion being asynchronous with the second motion. A synthetic physiological signal generator is synchronized with the component of the first motion, wherein an output signal from the generator, in combination with a sensed position of the fiducial, may be used by the radiation therapy device in tracking the target.

摘要翻译： 一种用于使用放射治疗装置验证目标跟踪的目标运动模拟器系统。 该系统包括耦合到模拟第一组织的第一运动的第一运动致动器的辐射检测目标和耦合到模拟来自第一组织的第二组织偏移的第二运动的第二运动致动器的基准，第一运动的分量 与第二动作异步。 合成生理信号发生器与第一运动的分量同步，其中来自发生器的输出信号与基准的感测位置的组合可以被放射线治疗装置用于跟踪目标。

公开(公告)号：US20060078196A1

公开(公告)日：2006-04-13

申请号：US10965494

申请日：2004-10-13

申请人： Thilaka Sumanaweera ,  Anming Cai ,  Kutay Ustuner

发明人： Thilaka Sumanaweera ,  Anming Cai ,  Kutay Ustuner

IPC分类号： G06K9/00

CPC分类号： G01S15/8993 ,  G01S7/52085 ,  G01S15/8915 ,  G01S15/8925 ,  G01S15/8995

摘要： Multiple apexes or intersections of scan lines are used to control the desired scan region for three dimensional scanning. Where a two dimensional transducer array is not square or circular or if the element spacing in azimuth and elevation is unequal, multiple apexes allow for optimization of the scanned volume to the transducer characteristics. The different apexes may be spaced from each other and relative to the transducer at various locations. Distributed patterns of apexes may be provided, such as spacing a plurality of apexes along a line in elevation and another set of apexes along a line in azimuth.

摘要翻译： 扫描线的多个顶点或交点用于控制用于三维扫描的所需扫描区域。 如果二维换能器阵列不是正方形或圆形，或者如果方位和高程中的元素间距不相等，则可以使多个顶点对扫描体积进行优化。 不同的顶点可以在各个位置处彼此间隔开并且相对于换能器间隔开。 可以提供顶点的分布图案，例如沿着高度线沿多个顶点间隔多个顶点，另一组顶点沿着方位角线。