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公开(公告)号：US20060101641A1
公开(公告)日：2006-05-18
申请号：US11217246
申请日：2005-09-01
申请人： Ryan True , Thomas Horn
发明人： Ryan True , Thomas Horn
IPC分类号： H01R43/00 , H01H9/00 , B22D11/126
CPC分类号： H01F41/0246 , Y10T29/49169 , Y10T29/49206 , Y10T29/49988 , Y10T29/5313
摘要： Armature pin assemblies and methods for forming the same are described. A first portion of a pin member is placed in a die cavity so as to expose a second portion of the pin member. An amount of metal powder is placed into the die cavity so as envelope the second portion of the pin member. A press member is then brought into contact with the metal powder so as to compress the same and form an armature member. The pin member is fastened to the armature member by the press operation so as to form a unitary armature pin assembly.
摘要翻译： 描述了电枢销组件及其形成方法。 销构件的第一部分被放置在模腔中，以便露出销构件的第二部分。 将一定量的金属粉末放置在模腔中，以便将销部件的第二部分包围。 然后将压制构件与金属粉末接触以将其压缩并形成电枢构件。 销构件通过按压操作紧固到电枢构件，以形成单一的电枢销组件。
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公开(公告)号：US07030216B2
公开(公告)日：2006-04-18
申请号：US10117841
申请日：2002-04-05
申请人： Thomas Horn , Ronald N. Zuckermann
发明人： Thomas Horn , Ronald N. Zuckermann
IPC分类号： C07K1/00
摘要： Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.
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13.发明授权Method of applying a connecting element to a high-frequency cable in a moisture-proof manner 失效将连接元件以防潮的方式施加到高频电缆的方法
公开(公告)号：US6148513A
公开(公告)日：2000-11-21
申请号：US994857
申请日：1997-12-19
申请人： Jurgen Schiefer , Thomas Horn , Michael Stansbie
发明人： Jurgen Schiefer , Thomas Horn , Michael Stansbie
CPC分类号： H01R13/5205 , H01R13/5216 , H01R9/0521 , Y10T29/49123 , Y10T29/49176
摘要： A method is indicated for applying a connecting element (3) in a moisture-proof manner to a high-frequency cable (1) containing at least one tubular electric conductor (7) which is surrounded by a sheath made of an insulating material. First, the sheath (10) is removed from the end of the conductor (7). Then a socket-shaped metal contact part (11,12) is attached to this end of the conductor (7) so that it makes electrical contact. A sealing material is placed between the contact part and conductor (7) on the one hand, and the contact part and the sheath (10) on the other. The sealing material for a seal (15) is made up of at least two components, which after the installation of the contact part (11, 12) enlarges its volume to such a degree that it fills the peripheral hollow space between the contact part (11, 12) and the conductor (7), and between the contact part (11, 12) and the sheath (10), at least in the transition area from the conductor (7) to the sheath (10).
摘要翻译： 指示用于将防水方式的连接元件（3）施加到包含由绝缘材料制成的护套包围的至少一个管状导电体（7）的高频电缆（1）的方法。 首先，从导体（7）的端部移除护套（10）。 然后，一个插座形金属接触部分（11,12）连接到导体（7）的这一端，使其电接触。 一方面，密封材料放置在接触部分和导体（7）之间，并且接触部分和护套（10）在另一方面。 用于密封件（15）的密封材料由至少两个部件组成，其在接触部分（11,12）的安装之后将其体积扩大至使其填充接触部分 至少在从导体（7）到护套（10）的过渡区域中，接触部分（11,12）和导体（7）之间以及接触部分（11,12）和护套（10）之间。
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公开(公告)号：US5979839A
公开(公告)日：1999-11-09
申请号：US886930
申请日：1997-07-02
申请人： Thomas Horn , Hans Jurgen Schiefer
发明人： Thomas Horn , Hans Jurgen Schiefer
CPC分类号： F16L3/1091 , H01Q1/1221 , H01Q13/203 , H02G3/26
摘要： A fitting for fastening a cable (2) to a wall (1) is indicated, which comprises a base (6) to be fastened to the wall (1) and a cap (7). The end of the base (6) which in the installed position faces away from the wall has a trough (8) for receiving the cable (2), which in the installed position is closed by the cap (7). The base (6) has three separate faces (9, 10, 11) which form the corners of a triangle for the attachment to the wall (1). The part of the cap (7) which in the installed position is applied against the cable is elastically deformable.
摘要翻译： 指示用于将电缆（2）紧固到壁（1）的配件，其包括要紧固到壁（1）的基部（6）和盖（7）。 底座（6）的安装位置远离墙壁的端部具有用于容纳电缆（2）的槽（8），该安装位置由盖（7）封闭。 底座（6）具有三个独立的面（9,10,11），它们形成用于连接到墙壁（1）的三角形的角部。 安装位置上的盖子（7）的部分被弹性地变形。
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公开(公告)号：US5710264A
公开(公告)日：1998-01-20
申请号：US478085
申请日：1995-06-07
申请人： Michael S. Urdea , Thomas Horn , Chu-An Chang , Brian Warner , Timothy J. Fultz
发明人： Michael S. Urdea , Thomas Horn , Chu-An Chang , Brian Warner , Timothy J. Fultz
摘要： Large comb-type branched polynucleotides useful as amplifier molecules in nucleic acid hybridization assays are provided, the polynucleotides comprising: a polynucleotide backbone having at least about 15 multifunctional nucleotides, each of which defines a sidechain site and a first single-stranded oligonucleotide unit that is capable of binding specifically to a first single-stranded polynucleotide sequence of interest; and pendant polynucleotide sidechains extending from said multifunctional nucleotides each comprising iterations of a second single-stranded oligonucleotide unit that is capable of binding specifically to a second single-stranded polynucleotide sequence of interest, the total number of iterations in all sidechains being at least 20. Methods of making these polynucleotides are also provided.
摘要翻译： 提供了用作核酸杂交测定中的放大分子的大梳状支化多核苷酸，所述多核苷酸包含：多核苷酸主链，其具有至少约15个多功能核苷酸，每个核苷酸限定侧链位点和第一单链寡核苷酸单元， 能够特异性结合目标的第一单链多核苷酸序列; 和从所述多功能核苷酸延伸的侧挂多核苷酸侧链，其每个包括能够特异性结合目标的第二单链多核苷酸序列的第二单链寡核苷酸单元的迭代，所有侧链的总迭代次数至少为20。 还提供制备这些多核苷酸的方法。
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16.发明授权Polynucleotide reagents containing modified deoxyribose moieties and associated methods of synthesis and use 失效含有修饰脱氧核糖部分的多核苷酸试剂和相关合成和使用方法
公开(公告)号：US5594117A
公开(公告)日：1997-01-14
申请号：US429197
申请日：1995-04-26
申请人： Michael S. Urdea , Thomas Horn
发明人： Michael S. Urdea , Thomas Horn
IPC分类号： G01N33/58 , C07D307/20 , C07F9/655 , C07H15/04 , C07H21/00 , C07H21/04 , C12Q1/68 , C07H21/02 , C07H19/00
CPC分类号： C07H15/04 , C07F9/65515 , C07H21/00 , C12Q1/6823
摘要： Methods and reagents are provided for synthesizing polynucleotides containing modified deoxyribose residues. Monomeric reagents having the structural formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined herein, are used to create polynucleotides having nonnucleotidic moieties --A--Z--(R.sup.9).sub.n at the 1 position of selected deoxyribose units. The polynucleotides so provided are useful in a variety of hybridization assay formats.
摘要翻译： 提供了用于合成含有修饰脱氧核糖残基的多核苷酸的方法和试剂。 具有结构式（I）的单体试剂（I）其中R 1，R 2，R 3，R 4和R 5如本文所定义，被用于产生在第1位上具有非核苷酸部分-AZ-（R 9）n的多核苷酸 选择脱氧核糖单位。 如此提供的多核苷酸可用于多种杂交测定形式。
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公开(公告)号：US5552280A
公开(公告)日：1996-09-03
申请号：US384630
申请日：1995-02-06
申请人： Michael S. Urdea , Thomas Horn
发明人： Michael S. Urdea , Thomas Horn
CPC分类号： C07H21/00 , C12Q1/6834
摘要： A polynucleotide which has been modified by a hydrophobic moiety so that the polynucleotide attaches to a substrate by the hydrophobic moiety, rather than by a portion of the polynucleotide, thereby allowing the polynucleotide to be available for hybridization.
摘要翻译： 已经被疏水部分修饰的多核苷酸，使得多核苷酸通过疏水部分而不是部分多核苷酸附着于底物，从而允许多核苷酸可用于杂交。
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公开(公告)号：US5252760A
公开(公告)日：1993-10-12
申请号：US87158
申请日：1987-08-18
申请人： Michael S. Urdea , Thomas Horn
发明人： Michael S. Urdea , Thomas Horn
IPC分类号： C07F9/09 , C07F9/24 , C07F9/40 , C07F9/655 , C07H19/16 , C07H21/00 , C07H21/04 , C07F9/141 , C07F9/22 , C07H11/04
CPC分类号： C07H21/00 , C07F9/091 , C07F9/2408 , C07H19/16
摘要： A method of phosphorylating a nucleoside or an oligonucleotide chain having a free 2', 3' or 5' hydroxyl moiety is provided. The method involves the use of a phosphorylating reagent which is selected such that the extent of phosphorylation can be monitored colorimetrically, easily and accurately. The phosphorylating reagent contains an aromatic species such as a dimethoxytrityl group that is cleavable with acid and colorimetrically detectable upon release. Examples of phosphorylating reagents which are useful in conjunction with the disclosed method include ##STR1##
摘要翻译： 提供了使游离的2'，3'或5'羟基部分的核苷或寡核苷酸链磷酸化的方法。 该方法包括使用磷酸化试剂，其被选择为使得可以比色，容易且准确地监测磷酸化程度。 磷酸化试剂含有芳族物质如二甲氧基三苯甲基，可用酸进行切割，并且在释放时可以进行比色检测。 与所公开的方法结合使用的磷酸化试剂的实例包括
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公开(公告)号：US5093232A
公开(公告)日：1992-03-03
申请号：US945876
申请日：1986-12-23
申请人： Michael S. Urdea , Thomas Horn
发明人： Michael S. Urdea , Thomas Horn
摘要： Modified nucleotides are provided which have the structure ##STR1## wherein R.sup.1 is a reactive group derivatizable with a detectable label, R.sup.2 is an optional linking moiety including an amide, thioether or disulfide linkage or a combination thereof, R.sup.3 is hydrogen, methyl, bromine, fluorine or iodine, R.sup.4 is hydrogen, an acid-sensitive, base-stable blocking group of an acyl capping group, R.sup.5 is hydrogen or a phosphorus derivative, R.sup.6 is H, OH, or OR where R is a protecting group and x is an integer in the range of 1 and 8 inclusive. Methods of synthesizing the derivatizable nucleotide are disclosed, as are labeled polynucleotide probes prepared therefrom.
摘要翻译： 提供了具有结构“IMAGE”的修饰的核苷酸，其中R 1是可用可检测标记可衍生的反应性基团，R 2是任选的连接部分，包括酰胺，硫醚或二硫键或其组合，R 3是氢，甲基，溴， 氟或碘，R4是氢，酰基封端基团的酸敏感的碱稳定的封闭基团，R 5是氢或磷衍生物，R 6是H，OH或OR，其中R是保护基，x是 整数在1和8的范围内。 公开了合成可衍生核苷酸的方法，以及由其制备的标记的多核苷酸探针。
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公开(公告)号：US07408023B2
公开(公告)日：2008-08-05
申请号：US11398576
申请日：2006-04-04
申请人： Thomas Horn , Ronald N. Zuckermann
发明人： Thomas Horn , Ronald N. Zuckermann
IPC分类号： C07K2/00
摘要： Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.
摘要翻译： 描述了与固相载体，间隔基团和/或连接部分缀合的具有潜在生物学活性的特别是拟肽的分子及其制备方法。 在一些情况下，本发明的分子完全由固相合成制备。 在其他情况下，间隔基团是亲水性的，含有它们的组合物，以及使用化学选择性连接部分固定相合成不同结构的拟肽。
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