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公开(公告)号：US20110245480A1
公开(公告)日：2011-10-06
申请号：US13099280
申请日：2011-05-02
IPC分类号： C07H21/00
CPC分类号： A61K39/0011 , A61K2039/522 , A61K2039/523 , C07K14/195 , C07K14/705 , C07K2319/00 , C12N15/74
摘要： The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes.
摘要翻译： 本发明提供了含有包含编码异源抗原的核酸的多核苷酸以及融合蛋白质伴侣的细菌。 还提供了用于介导位点特异性重组的载体和包含可除去的抗生素抗性基因的载体。
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12.发明申请METHODS AND COMPOSITIONS USING LISTERIA FOR ENHANCING IMMUNOGENICITY BY PRIME BOOST 有权利用LISTERIA增强免疫原性的方法和组合公开(公告)号：US20100233212A1
公开(公告)日：2010-09-16
申请号：US12374288
申请日：2007-07-17
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/521 , A61K2039/522 , A61K2039/523 , A61K2039/53 , A61K2039/545 , C12N2799/022 , C12N2799/023 , Y02A50/412
摘要： Provided herein are prime-boost regimens and materials used therein. The prime-boost regimens enhance the immune response to a target antigen. The vaccines used for boost are comprised of recombinant attenuated metabolically active Listeria that encodes an expressible antigen that is cross-reactive with the target antigen. In some examples, the immune response is a cellular immune response.
摘要翻译： 本文提供的是初始加强方案和其中使用的材料。 初始 - 加强方案增强对靶抗原的免疫应答。 用于加强的疫苗由重组减毒的代谢活性利斯特氏菌组成，其编码与靶抗原交叉反应的可表达抗原。 在一些实例中，免疫应答是细胞免疫应答。
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公开(公告)号：US20120121643A1
公开(公告)日：2012-05-17
申请号：US11713765
申请日：2007-03-01
CPC分类号： C07K14/195 , A61K39/0011 , A61K2039/522 , A61K2039/523 , A61K2039/53 , C07K14/705 , C07K2319/00 , C12N15/74
摘要： The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes.
摘要翻译： 本发明提供了含有包含编码异源抗原的核酸的多核苷酸以及融合蛋白质伴侣的细菌。 还提供了用于介导位点特异性重组的载体和包含可除去的抗生素抗性基因的载体。
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14.发明申请COMPOSITIONS COMPRISING PRFA* MUTANT LISTERIA AND MEHTODS OF USE THEREOF 审中-公开包含PRFA *突变体肠梗阻的组合物及其使用的MEHTODE公开(公告)号：US20110287055A1
公开(公告)日：2011-11-24
申请号：US12993115
申请日：2009-05-18
申请人： Peter M. Lauer , Thomas W. Dubensky, JR. , Justin Skoble , Dirk G. Brockstedt , William Stanford Luckett, JR. , William Hanson
发明人： Peter M. Lauer , Thomas W. Dubensky, JR. , Justin Skoble , Dirk G. Brockstedt , William Stanford Luckett, JR. , William Hanson
CPC分类号： C12N15/74 , A61K39/0208 , A61K2039/522 , A61K2039/523 , Y02A50/412
摘要： The invention provides recombinant Listeria that constitutively express Prf A and comprise polynucleotides that encode polypeptides such as tumor or infectious agent antigens, operably linked to a PrfA responsive regulatory agent. Methods of using the Listeria, and compositions thereof, to induce or enhance an immune response and/or in the treatment of disease are provided. Methods of producing the bacteria are also provided.
摘要翻译： 本发明提供组成型表达Prf A的重组利斯特氏菌，并且包含与PrfA反应性调节剂可操作地连接的编码多肽例如肿瘤或感染因子抗原的多核苷酸。 提供了使用利斯特氏菌及其组合物诱导或增强免疫应答和/或治疗疾病的方法。 还提供了生产细菌的方法。
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15.发明申请LENTIVIRAL VECTORS PSEUDOTYPED WITH A SINDBIS VIRUS ENVELOPE GLYCOPROTEIN 审中-公开使用SINDBIS VIRUS ENVELOPE GLYCOPROTEIN的LENIVEIRAL VECTORS PSEUDOTYPED公开(公告)号：US20110064763A1
公开(公告)日：2011-03-17
申请号：US12842609
申请日：2010-07-23
摘要： Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).
摘要翻译： 提供包含辛德毕斯病毒E2糖蛋白变体和包含感兴趣序列的慢病毒载体基因组的慢病毒载体颗粒。 一种慢病毒载体颗粒，包括：（a）包含辛德毕斯病毒E2糖蛋白变体的包膜; 和（b）包含感兴趣序列的慢病毒载体基因组; 其中E2糖蛋白变体便于慢病毒载体颗粒感染树突状细胞，并且其中E2糖蛋白变体与参考序列（HR应变）相比具有减少的与硫酸乙酰肝素的结合。
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公开(公告)号：US20100129406A1
公开(公告)日：2010-05-27
申请号：US12439287
申请日：2007-08-31
CPC分类号： A61K39/0208 , A61K2039/523 , A61K2039/53 , C07K14/195 , C12N2799/021
摘要： The invention provides Listeria that, in addition to comprising polynucleotides that encode heterologous polypeptides such as tumor or infectious agent antigens, have been modified to express holin proteins that facilitate the delivery of the heterologous polypeptides, or polynucleotides encoding the same, outside of the bacteria. In some particular embodiments, the Listeria generate viral-derived, self-replicating RNAs that direct expression of the heterologous polypeptides in the cytosol of infected cells. Methods of using the Listeria, and compositions thereof, to induce immune response and/or in the prevention or treatment of disease are also provided. Methods of producing the bacteria are also provided.
摘要翻译： 本发明提供了李斯特菌，除了包含编码异源多肽如肿瘤或感染性抗原的多核苷酸之外，已经被修饰以表达促进异源多肽或其编码它们的多核苷酸在细菌外部的促进蛋白。 在一些具体实施方案中，利斯特氏菌产生将异源多肽的表达引导到受感染细胞的细胞溶质中的病毒衍生的自我复制的RNA。 还提供了使用利斯特氏菌及其组合物诱导免疫应答和/或预防或治疗疾病的方法。 还提供了生产细菌的方法。
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公开(公告)号：US20120288515A1
公开(公告)日：2012-11-15
申请号：US13458098
申请日：2012-04-27
IPC分类号： A61K39/00 , A61P35/00 , A61P31/04 , A61K39/245 , A61P31/12
CPC分类号： A61K39/21 , A61K39/12 , A61K39/245 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , C12N2710/16634 , C12N2740/15034
摘要： Synthetic long peptides and an adjuvant are formulated together and administered to a subject in order to raise an immune response. In certain embodiments, the adjuvant is GLA.
摘要翻译： 将合成的长肽和佐剂一起配制并施用于受试者以提高免疫应答。 在某些实施方案中，佐剂是GLA。
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公开(公告)号：US20120100170A1
公开(公告)日：2012-04-26
申请号：US13055675
申请日：2009-07-23
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C07K2319/00 , C12N2770/24222 , C12N2770/24234 , C12N2830/55
摘要： The present invention provides compositions and methods for delivery of one or more hepatitis C virus (HCV) antigens using a bacterium recombinantly encoding and expressing such antigens. In certain embodiments, the bacterial platform comprises the use of attenuated and killed but metabolically active forms of Listeria monocytogenes.
摘要翻译： 本发明提供使用重组编码和表达这种抗原的细菌递送一种或多种丙型肝炎病毒（HCV）抗原的组合物和方法。 在某些实施方案中，细菌平台包括使用减毒和杀死但代谢活性的单核细胞增生利斯特氏菌形式。
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19.发明申请MODIFIED FREE-LIVING MICROBES, VACCINE COMPOSITIONS AND METHODS OF USE THEREOF 有权改性免费生活微生物，疫苗组合物及其使用方法公开(公告)号：US20100068230A1
公开(公告)日：2010-03-18
申请号：US10883599
申请日：2004-06-30
申请人： Thomas W. Dubensky, JR. , Dirk G. Brockstedt , John E. Hearst , David N. Cook , William S. Luckett, JR.
发明人： Thomas W. Dubensky, JR. , Dirk G. Brockstedt , John E. Hearst , David N. Cook , William S. Luckett, JR.
CPC分类号： A61K39/07 , A61K2039/5254 , A61K2039/5256 , Y02A50/401
摘要： Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.
摘要翻译： 提供了自由活的微生物，其中已经修饰了核酸，使得微生物被减弱以用于增殖和/或包含减弱微生物修复其核酸的能力的遗传突变。 还提供了使用修饰的微生物来加载，激活和/或成熟抗原呈递细胞的方法。 还提供了包含修饰的微生物和/或抗原呈递细胞的疫苗组合物和使用疫苗的方法。 可以进一步修饰微生物以包括异源抗原，例如肿瘤抗原或感染性疾病抗原，用作抗癌或感染性疾病的疫苗。
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