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公开(公告)号：US4661353A
公开(公告)日：1987-04-28
申请号：US804411
申请日：1985-12-04
CPC分类号： C12P1/06
摘要： CL-1577-B.sub.4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound of CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions.CL-1577-B.sub.4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line.A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.
摘要翻译： CL-1577-B4化合物是通过在无氧条件下溶解分解得到的CL-1577B化合物的CL-1577B化合物，其由在有氧条件下命名为ATCC 39363的纯化的放线菌菌株的发酵作用获得。 CL-1577-B4化合物是一种有效的抗微生物剂，具有抗多种革兰氏阳性和革兰氏阴性细菌，酵母菌和真菌的活性。 此外，该化合物对P388鼠白血病细胞系具有体内活性，对L1210鼠白血病细胞系具有体外活性。 还公开了制备该化合物的方法以及其使用的药物组合物和方法。
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公开(公告)号：US4594248A
公开(公告)日：1986-06-10
申请号：US712294
申请日：1985-03-15
CPC分类号： C12P1/06
摘要： CL-1577-B.sub.4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound or CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions.CL-1577-B.sub.4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line.A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.
摘要翻译： CL-1577-B4化合物通过在无氧条件下的溶剂分解得到，CL-1577A化合物或CL-1577B化合物是在有氧条件下从称为ATCC 39363的纯化的放线菌菌株的发酵作用获得的。 CL-1577-B4化合物是一种有效的抗微生物剂，具有抗多种革兰氏阳性和革兰氏阴性细菌，酵母菌和真菌的活性。 此外，该化合物对P388鼠白血病细胞系具有体内活性，对L1210鼠白血病细胞系具有体外活性。 还公开了制备该化合物的方法以及其使用的药物组合物和方法。
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公开(公告)号：US5463035A
公开(公告)日：1995-10-31
申请号：US396443
申请日：1995-02-28
IPC分类号： B01J41/20 , A61K31/44 , A61K31/65 , A61K38/05 , C07H1/08 , C07H19/052 , C07H19/23 , C07H19/04
CPC分类号： A61K31/44 , A61K31/65 , A61K38/05 , C07H19/052
摘要： A process for purifying pentostatin from a crude fermentation beer comprising the steps of 1) applying the fermentation beer to a strong cation exchange resin; 2) eluting with ammonium hydroxide; 3) concentrating the eluate; 4) applying the concentrated eluate to a strongly basic anion exchange resin charged with borate ion; 5) eluting with water; 6) applying this eluate to styrene-divinylbenzene beads prewashed with ethanol; 7) eluting the beads with water; and 8) recrysllyzing the pentostatin from water and methanol to yield a product that is greater than 99.7% pure.
摘要翻译： 一种从粗发酵啤酒中纯化喷司他丁的方法，包括以下步骤：1）将发酵啤酒施用于强阳离子交换树脂; 2）用氢氧化铵洗脱; 3）浓缩洗脱液; 4）将浓缩洗脱液加到装有硼酸盐离子的强碱性阴离子交换树脂中; 5）用水洗脱; 6）将该洗脱液用乙醇预洗的苯乙烯 - 二乙烯基苯珠; 7）用水洗珠子; 和8）从水和甲醇中再次研磨喷他他他得到纯度大于99.7％的产物。
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公开(公告)号：US4771070A
公开(公告)日：1988-09-13
申请号：US912684
申请日：1986-09-26
IPC分类号： C07D309/22 , C12P17/06 , A61K31/365 , C07D309/38
CPC分类号： C07D309/22 , C12P17/06
摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties.The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound.The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.
摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够产生也具有抗肿瘤性质的抗微生物化合物CL-1957A。 抗微生物化合物CL-1957A是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957A化合物，然后分离出CL-1957A化合物。 还公开了抗生素化合物CL-1957A和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。
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15.发明授权2-chloropentostatin compound having adenosine diaminase inhibitory activity 失效具有腺苷二氨基酶抑制活性的2-氯磷酸抑制素化合物
公开(公告)号：US4713372A
公开(公告)日：1987-12-15
申请号：US796139
申请日：1985-11-08
申请人： John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac , Marjorie A. Underhill
发明人： John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac , Marjorie A. Underhill
IPC分类号： C07H19/052 , C12P19/38 , A61K31/70 , C07H17/02
CPC分类号： C12R1/01 , C07H19/052 , C12P19/38
摘要： 2'-Chloropentostatin is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabinosyl)adenine. A pure strain of actinomycete, designated ATCC 39365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.
摘要翻译： 2'-Chloropostostatin是腺苷脱氨酶的有效抑制剂，并且具有用作增强抗病毒剂用于治疗DNA病毒活性的药剂的用途，所述药物含有腺嘌呤部分，例如9-（β-D-阿拉伯糖基） 腺嘌呤 还公开了一种能够产生2'-氯生物素抑制素的命名为ATCC 39365的放线菌纯化菌株，通过需氧发酵生产2'-氯生物素抑制素的方法，以及包含2'-氯磷酸内酯的药物组合物。
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公开(公告)号：US4918100A
公开(公告)日：1990-04-17
申请号：US763577
申请日：1985-08-08
IPC分类号： C07D309/22 , C07D309/32 , C12P17/06
CPC分类号： C12R1/01 , C07D309/22 , C07D309/32 , C12P17/06
摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957B which also exhibits antitumor properties.The antimicrobial compound CL-1957B is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957B compound is produced, and subsequently isolating the compound.The antibiotic compound CL-1957B, its pharmaceutically acceptable salts, the pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.
摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够生产也具有抗肿瘤性质的抗微生物化合物CL-1957B。 抗微生物化合物CL-1957B是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957B化合物，然后分离该化合物。 还公开了抗生素化合物CL-1957B及其药学上可接受的盐，包含该物质的药物组合物和药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。
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公开(公告)号：US4551529A
公开(公告)日：1985-11-05
申请号：US539517
申请日：1983-10-06
IPC分类号： A61K31/52 , A61K31/522 , A61P31/04 , A61P35/00 , C07D473/18 , C12P17/18 , C12R1/01 , C12R1/04
CPC分类号： C07D473/18 , C12P17/182 , Y10S435/826
摘要： A purified isolate of an actinomycete identified as ATCC 39364 is capable of producing the antimicrobial/antitumor compound 2-amino-1,9-dihydro-6H-purine-6-one-7-oxide, commonly known as guanine-N.sup.7 -oxide.Guanine-N.sup.7 -oxide is produced by cultivating isolate ATCC 39364 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of the compound is produced and thereafter isolating the compound.The antibiotic/antitumor compound guanine-N.sup.7 -oxide and pharmaceutical compositions comprising this compound or one of its pharmaceutically acceptable salts together with a pharmaceutically acceptable carrier are also disclosed as is a method of treating microbial infections in a mammal or of treating tumors in a mammal.
摘要翻译： 确定为ATCC 39364的放线菌的纯化分离物能够产生通常称为鸟嘌呤-N7氧化物的抗微生物/抗肿瘤化合物2-氨基-1,9-二氢-6H-嘌呤-6-酮-7-氧化物。 鸟嘌呤-N7氧化物是通过在需氧条件下培养分离物ATCC 39364，在含有可吸收的碳源和氮源的培养基中培养，直到产生大量的化合物，然后分离化合物。 还公开了抗生素/抗肿瘤复合物鸟嘌呤-N7氧化物和包含该化合物或其药学上可接受的盐的一种药物组合物与药学上可接受的载体的药物组合物，一种治疗哺乳动物微生物感染或治疗哺乳动物肿瘤的方法 。
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公开(公告)号：US4554162A
公开(公告)日：1985-11-19
申请号：US607056
申请日：1984-05-04
申请人： Cynthia A. Young , John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac
发明人： Cynthia A. Young , John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac
摘要： A strain of actinomycete, NRRL 15758, is capable of producing the CL-1724 complex of compounds under conditions of aerobic fermentation in the presence of assimilable sources of carbon and nitrogen. The compound CL-1724B-2 exhibiting antimicrobial and antitumor activity, is claimed together with pharmaceutical compositions and methods of treating microbial infections and tumors in mammals employing these pharmaceutical compositions.
摘要翻译： 放线菌菌株NRRL 15758能够在需氧发酵的条件下在可同化的碳源和氮源的情况下生产化合物的CL-1724复合物。 表现出抗微生物和抗肿瘤活性的化合物CL-1724B-2与使用这些药物组合物的哺乳动物中治疗微生物感染和肿瘤的药物组合物和方法一起是要求的。
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