摘要:
Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要:
Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要:
The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要:
Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要:
Methods, apparatuses and storage medium associated with ISA bridging with callback, are disclosed. In various embodiments, at least one computer-readable storage medium may include instructions configured to enable a target device with a target ISA, in response to execution of the instructions, to provide an ISA bridging layer to the target device to facilitate a library service to callback a callback function of an application. The library service may be implemented for the target ISA, and the application may be implemented at least partially for a source ISA that may be different from the target ISA. The ISA bridging layer may include a source ISA emulator and a library emulator configured to cooperate to enable the application to call the library service, and the library service to callback the callback function, across the two instruction set architectures. Other embodiments may be disclosed or claimed.
摘要:
This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
摘要:
The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要:
Methods, apparatuses and storage medium associated with ISA bridging with support for virtual functions, are disclosed. In embodiments, at least one computer-readable storage medium may include instructions configured to enable a target device with a target ISA, in response to execution, to provide an ISA bridging layer to the target device to facilitate a library service of a library of the target device to call a virtual function of the library, while servicing an application operating on the target device, where the application has an overriding implementation. The ISA bridging layer may include a loader configured to load the application for execution, and as part of loading the application, detect the virtual function and modify a virtual function table of the application to enable the call. Other embodiments may be disclosed or claimed.