公开(公告)号：US4357465A

公开(公告)日：1982-11-02

申请号：US187014

申请日：1980-09-15

申请人： Hamao Umezawa ,  Sumio Umezawa ,  Shigeo Seki ,  Shunzo Fukatsu ,  Shuntaro Yasuda

发明人： Hamao Umezawa ,  Sumio Umezawa ,  Shigeo Seki ,  Shunzo Fukatsu ,  Shuntaro Yasuda

IPC分类号： C07H15/236 ,  A61K31/71 ,  C07H15/22

CPC分类号： C07H15/234 ,  Y02P20/55

摘要： New routes are provided for the synthesis of 3',4'-dideoxykanamycin B which is effective in inhibiting kanamycin-resistant organisms from kanamycin B through new intermediate, of which a fundamental process comprises a new reaction of a 3',4'-epoxy derivative of amino- and hydroxyl-protected kanamycin B with a xanthate to form a corresponding 3',4'-dideoxy-3'-eno derivative followed by removal of the amino- and hydroxyl-protecting groups thereof and by hydrogenation of the resulting 3',4'-dideoxy-3'-eno-kanamycin B. A 3',4'-episulfide derivative corresponding to the 3',4'-epoxy derivative which is formed as second product in the reaction of 3',4'-epoxy derivative with xanthate is also used as intermediate for the preparation of 3',4'-dideoxykanamycin B.

摘要翻译： 提供了用于合成3'，4'-双脱氧卡那霉素B的新途径，其通过新的中间体有效抑制卡那霉素B的卡那霉素抗性生物，其中基本方法包括3'，4'-环氧基 氨基和羟基保护的卡那霉素B与黄原酸酯的衍生物形成相应的3'，4'-二脱氧-3'-烯衍生物，然后除去其氨基和羟基保护基团，并通过氢化得到的3 '，4'-二脱氧-3'-烯 - 卡那霉素B.对应于3'，4'-环氧衍生物的3'，4'-环硫化物衍生物，其在3'，4' 含有黄原酸酯的环氧衍生物也用作制备3'，4'-双脱氧卡那霉素B的中间体。

公开(公告)号：US4188480A

公开(公告)日：1980-02-12

申请号：US933188

申请日：1978-08-10

申请人： Takeshi Nakamura ,  Satoru Nakabayashi ,  Shunzo Fukatsu ,  Shigeo Seki

发明人： Takeshi Nakamura ,  Satoru Nakabayashi ,  Shunzo Fukatsu ,  Shigeo Seki

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H1/00

CPC分类号： C07H17/08

摘要： A 9,3"-di-acyl derivative of a macrolide antibiotic can be readily produced by reacting a macrolide antibiotic or an acyl derivative thereof with an organic acid halide, particularly an alkanoic acid halide, in a solvent and in the presence of a molecular sieve consisting of a synthetic zeolite and then de-acylating partially the resultant acylation products by a partial hydrolysis in an aqueous alcohol to give the 9,3"-di-acyl derivative of the macrolide antibiotic.

摘要翻译： 通过使大环内酯类抗生素或其酰基衍生物与有机酰卤，特别是链烷酰卤反应，在溶剂中，并存在下可以容易地制备大环内酯类抗生素的9,3“ - 二 - 酰基衍生物 分子筛由合成沸石组成，然后通过在含水醇中部分水解将所得酰化产物部分脱酰化，得到大环内酯类抗生素的9,3“ - 二 - 酰基衍生物。

公开(公告)号：US4175185A

公开(公告)日：1979-11-20

申请号：US892179

申请日：1978-03-31

申请人： Shigeo Seki ,  Satoru Nakabayashi ,  Toshinori Saito ,  Shunzo Fukatsu ,  Shokichi Nakajima ,  Toshiyasu Ishimaru

发明人： Shigeo Seki ,  Satoru Nakabayashi ,  Toshinori Saito ,  Shunzo Fukatsu ,  Shokichi Nakajima ,  Toshiyasu Ishimaru

IPC分类号： C07D501/20 ,  C07D501/26

CPC分类号： C07D501/26

摘要： A process for preparing a cephalosporanic acid derivative or a 7-acylaminocephalosporanic acid derivative which comprises subjecting an esterifying agent to reaction in liquid sulfur dioxide in the presence of a base with an N-protected-cephalosporin C to obtain a diester, subjecting the diester to reaction in an inert solvent with an iminohalide forming agent to produce an iminohalide, subjecting the iminohalide with a lower alcohol to produce an iminoether, subjecting the product produced, after subjecting the iminoether to reaction with a reactive derivative of an organic acid, to hydrolysis and further eliminating the ester group of the carboxylic acid.

摘要翻译： 一种制备头孢菌酸衍生物或7-酰氨基头孢烷酸衍生物的方法，其包括在碱存在下，用N-保护型头孢菌素C使酯化剂在液态二氧化硫中进行反应，得到二酯， 在惰性溶剂中与亚氨基卤化物形成剂反应以产生亚氨基卤化物，使亚氨基卤化物与低级醇反应生成亚氨基醚，使亚氨基醚与有机酸的反应性衍生物反应后生成的产物水解和 进一步消除羧酸的酯基。

公开(公告)号：US5841371A

公开(公告)日：1998-11-24

申请号：US808646

申请日：1997-02-28

申请人： Shigeo Seki

发明人： Shigeo Seki

IPC分类号： G01D5/249 ,  G01D5/347 ,  G01D5/36 ,  H03M1/24 ,  H03M1/22

CPC分类号： G01D5/34715 ,  G01D5/36

摘要： An encoder signal generating device in which a light receiving element (1) is constituted by a one-chip planar type phototransistor array that has a plurality of light receiving portions (21). Thus, this encoder signal generating device needs no amplification circuit. Even when using this encoder signal generating device as a device of the multi-channel type, the size of the light receiving element (1) is reduced, in comparison with that of a conventional light receiving element. Moreover, a highly sensitive encoder signal generating device, which has good S/N characteristics, is obtained.

摘要翻译： 一种编码器信号发生装置，其中光接收元件（1）由具有多个光接收部分（21）的单芯片平面型光电晶体管阵列构成。 因此，该编码器信号发生装置不需要放大电路。 即使当使用该编码器信号发生装置作为多通道类型的装置时，与传统的光接收元件相比，光接收元件（1）的尺寸也减小了。 此外，获得具有良好S / N特性的高灵敏度编码器信号发生装置。

公开(公告)号：US5572199A

公开(公告)日：1996-11-05

申请号：US357446

申请日：1994-12-16

申请人： Shigeo Seki

发明人： Shigeo Seki

IPC分类号： G01D5/244 ,  G01D5/245 ,  G01D5/249 ,  H03M1/24 ,  H03M1/28 ,  H03M1/30 ,  G08C19/16

CPC分类号： G01D5/2455 ,  G01D5/2492 ,  H03M1/282 ,  H03M1/308

摘要： An absolute signal detecting method and an absolute encoder according to the present invention load a n-bit positional signal (3) to a counting circuit (12) through rotating a code plate (1) at power ON, and can obtain an absolute encoder signal (12A) after this load through performing count up/down of the counting circuit (12) with an incremental signal (2).

摘要翻译： 根据本发明的绝对信号检测方法和绝对式编码器通过在电源接通时旋转码板（1）将n位位置信号（3）加载到计数电路（12），并且可以获得绝对编码器信号 （12A）通过用增量信号（2）执行计数电路（12）的计数上/下计数器（12A）。

公开(公告)号：US4290972A

公开(公告)日：1981-09-22

申请号：US92940

申请日：1979-11-09

申请人： Toshio Yoneta ,  Seiji Shibahara ,  Shigeo Seki ,  Shunzo Fukatsu

发明人： Toshio Yoneta ,  Seiji Shibahara ,  Shigeo Seki ,  Shunzo Fukatsu

IPC分类号： C07C227/04 ,  A61K31/19 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C227/00 ,  C07C227/06 ,  C07C227/26 ,  C07C229/04 ,  C07C229/06 ,  C07C229/22 ,  C07C229/26 ,  C07C99/10 ,  C07C121/42 ,  C07C121/453

CPC分类号： C07C255/00 ,  Y02P20/55

摘要： 4-Amino-2-hydroxybutyric acid or 2,4-diaminobutyric acid may be readily produced by a new process comprising reacting a propionic acid compound containing a .beta.-carboxamido substituent (-CONH.sub.2) on the carbon atom at the 3-position and optionally containing hydroxyl substituent and protected or unprotected amino substituent on the .alpha.-carbon atom thereof, with an alkanoic acid anhydride in liquid pyridine to convert the carboxamido group into a nitrile group, with occasional acylation of a .alpha.-hydroxyl group, occasionally removing the alkanoyl group from the .alpha.-acyloxyl group of the resulting nitrile intermediate, and then reducing the resultant nitrile compound with hydrogen to convert the nitrile group into an aminomethyl group, and further optionally removing the residual amino-protecting group from the resultant 4-aminobutyric acid compound.

摘要翻译： 4-氨基-2-羟基丁酸或2,4-二氨基丁酸可以通过一种新方法容易地产生，包括使含有β-羧酰胺基取代基（-CONH 2）的丙酸化合物在3-位上的碳原子上和任选地 在其α-碳原子上含有羟基取代基和被保护或未被保护的氨基取代基，与链烷酸酐在液体吡啶中，将羧酰胺基转化为腈基，偶尔酰化α-羟基，偶尔除去烷酰基 由得到的腈中间体的α-酰氧基，然后用氢还原得到的腈化合物，将腈基转化为氨基甲基，进一步任选地从所得的4-氨基丁酸化合物中除去残留的氨基保护基。

公开(公告)号：US4159372A

公开(公告)日：1979-06-26

申请号：US883812

申请日：1978-03-06

申请人： Shigeo Seki ,  Satoru Nakabayashi ,  Ken Nishihata ,  Nobuo Itoh ,  Toshinori Saito ,  Masahiro Onodera ,  Shunzo Fukatsu

发明人： Shigeo Seki ,  Satoru Nakabayashi ,  Ken Nishihata ,  Nobuo Itoh ,  Toshinori Saito ,  Masahiro Onodera ,  Shunzo Fukatsu

IPC分类号： A61K31/545 ,  C07D501/04 ,  C07D501/20

CPC分类号： C07D501/20 ,  C07D501/04

摘要： A process for preparing a cephalosporin ester which comprises subjecting an organic halide or an alcohol to reaction with a cephalosporin acid, a cephalosporin acid halide or a salt thereof in the presence of liquid sulfur dioxide.

摘要翻译： 一种制备头孢菌素酯的方法，其包括在液体二氧化硫存在下使有机卤化物或醇与头孢菌素酸，头孢菌素酰卤或其盐反应。

公开(公告)号：US4128714A

公开(公告)日：1978-12-05

申请号：US654624

申请日：1976-02-02

申请人： Masao Koyama ,  Shigeo Seki

发明人： Masao Koyama ,  Shigeo Seki

IPC分类号： C07D501/10

CPC分类号： C07D501/10 ,  C07D501/14

摘要： A novel ester of 7-acylamido-3-methyl-cepham-4-carboxylic acid derivative and a process for the preparation thereof which comprises reacting penicillin sulfoxide ester with the metal halide, and a novel 7-acylamido-3-methyl-cepham-4-carboxylic acid derivative and a process for the preparation thereof which comprises reacting penicillin sulfoxide ester with the metal halide and decomposing the resultant in a reductive atmosphere.

摘要翻译： 一种7-酰基氨基-3-甲基 - 头孢烯-4-羧酸衍生物的新型酯及其制备方法，其包括使青霉素亚砜酯与金属卤化物反应，以及新的7-酰基氨基-3-甲基 - 头孢烯-4-羧酸衍生物， 4-羧酸衍生物及其制备方法，其包括使青霉素亚砜酯与金属卤化物反应并在还原气氛中分解所得物。

公开(公告)号：US4091202A

公开(公告)日：1978-05-23

申请号：US723832

申请日：1976-09-16

申请人： Hamao Umezawa ,  Sumio Umezawa ,  Shunzo Fukatsu ,  Shigeo Seki ,  Masao Murase ,  Shuntaro Yasuda

发明人： Hamao Umezawa ,  Sumio Umezawa ,  Shunzo Fukatsu ,  Shigeo Seki ,  Masao Murase ,  Shuntaro Yasuda

IPC分类号： C07H15/234 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/236 ,  C07H15/22 ,  A61K31/71

CPC分类号： C07H15/22 ,  C07H15/236

摘要： As new semi-synthetic antibiotic derivative are provided N-methanesulfonic acid derivatives of 3',4'-dideoxykanamycin B which are less toxic than the parent antibiotic and have useful high antibacterial activity. They are produced by interacting 3',4'-dideoxykanamycin B, an aldehyde such as paraformaldehyde and sulfurous acid or an alkali metal sulfite reagent.

摘要翻译： 作为新的半合成抗生素衍生物，提供3'，4'-二脱氧卡那霉素B的N-甲磺酸衍生物，其比亲本抗生素毒性小，具有很高的抗菌活性。 它们通过相互作用的3'，4'-双脱氧卡那霉素B，醛如多聚甲醛和亚硫酸或碱金属亚硫酸盐试剂而产生。

公开(公告)号：US3998816A

公开(公告)日：1976-12-21

申请号：US457280

申请日：1974-04-02

申请人： Shigeo Seki ,  Toshiyasu Ishimaru

发明人： Shigeo Seki ,  Toshiyasu Ishimaru

IPC分类号： C07D501/00 ,  C07D501/04 ,  C07D501/12 ,  C07D501/18 ,  C07D501/20 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  G03B11/04 ,  C07D501/60

CPC分类号： C07D501/18 ,  C07D501/00 ,  C07D501/04 ,  C07D501/12 ,  C07D501/24

摘要： New and useful cephem compounds derived from cephalosporin C are provided by this invention, which are valuable as intermediate for the synthesis of another bacteriocidally active cephem derivatives and which are readily extractable from its aqueous solution by means of an organic solvent and enable the cephalosporin C content in the aqueous fermentation broth filtrate to be recovered at an improved yield. Cephalosporin C present in the fermentation broth may be converted into the cephem compounds of this invention by reacting with a substituted chloroformate compound within said filtrate, and the cephem compounds so formed may then be extracted therefrom with an organic solvent. The cephem compounds of this invention further may be converted into a 7-acylamidocephalosporanic acid or 7-aminocephalosporanic acid through some successive reactions.