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    Biosensor
    12.
    发明授权
    Biosensor 有权
    生物传感器

    公开(公告)号：US07235170B2

    公开(公告)日：2007-06-26

    申请号：US10344671

    申请日：2002-05-13

    申请人： Motokazu Watanabe ,  Takahiro Nakaminami ,  Shin Ikeda ,  Shiro Nankai

    发明人： Motokazu Watanabe ,  Takahiro Nakaminami ,  Shin Ikeda ,  Shiro Nankai

    IPC分类号： C12Q1/26

    CPC分类号： C12Q1/006 ,  C12Q1/001 ,  C12Q1/54

    摘要： A biosensor that is highly responsive and capable of rapid and highly sensitive quantification of a specific component contained in a sample is provided. The biosensor of this invention comprises: an electrically insulating base plate; an electrode system comprising a working electrode and a counter electrode disposed on the base plate; and a reagent system comprising an oxidoreductase which catalyzes the oxidation reaction of glucose, gluconolactonase and a buffer. The buffer is selected from the group consisting of phthalic acid and its salts, maleic acid and its salts, succinic acid and its salts, phospholic acid and its salts, acetic acid and its salts, boric acid and its salts, citric acid and its salts, glycine, tris(hydroxymethyl)aminomethane, piperazine-N,N′-bis(2-ethane sulfonic acid) and the like.

    摘要翻译： 提供了一种生物传感器，其具有高响应性并且能够对包含在样品中的特定成分进行快速和高灵敏度的定量。 本发明的生物传感器包括：电绝缘基板; 电极系统，包括设置在所述基板上的工作电极和对置电极; 以及包含催化葡萄糖，葡糖酸内切酶和缓冲液的氧化反应的氧化还原酶的试剂体系。 缓冲剂选自邻苯二甲酸及其盐，马来酸及其盐，琥珀酸及其盐，磷酸及其盐，乙酸及其盐，硼酸及其盐，柠檬酸及其盐 ，甘氨酸，三（羟甲基）氨基甲烷，哌嗪-N，N'-双（2-乙磺酸）等。

    Electrode probe and body fluid examination equipment including the same
    13.
    发明授权
    Electrode probe and body fluid examination equipment including the same 有权
    电极探针和体液检查设备包括相同

    公开(公告)号：US6104940A

    公开(公告)日：2000-08-15

    申请号：US326350

    申请日：1999-06-04

    申请人： Motokazu Watanabe ,  Shin Ikeda ,  Toshihiko Yoshioka ,  Shiro Nankai

    发明人： Motokazu Watanabe ,  Shin Ikeda ,  Toshihiko Yoshioka ,  Shiro Nankai

    IPC分类号： G01N27/30 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/15 ,  A61B5/157 ,  A61B5/05

    CPC分类号： A61B5/1486 ,  A61B5/6848

    摘要： Disclosed is an electrode probe and a body fluid examination equipment enabling examination of a trace amount of body fluid. The electrode probe comprises an insulating needle member, a working electrode lead disposed in the needle member, a working electrode whose lead is protruding outside from the needle member, a counter electrode disposed on the surface of the needle member, a lead connected to the counter electrode, and a reagent layer disposed in contact with or in the vicinity of the working and counter electrodes of the electrode system. When a trace amount of body fluid leaking on the skin surface is brought into contact with the reagent layer, the reagent layer dissolves which results in electron transfer whereby information about the concentration of analyte in the body fluid can be obtained from the electrode system.

    摘要翻译： 公开了能够检测微量体液的电极探针和体液检查装置。 电极探针包括绝缘针构件，设置在针构件中的工作电极引线，其引线从针构件向外突出的工作电极，设置在针构件表面上的对电极，连接到计数器的引线 电极和设置成与电极系统的工作电极和对电极接触或附近的试剂层。 当皮肤表面泄漏的微量体液与试剂层接触时，试剂层溶解，导致电子转移，从而可以从电极系统获得关于体液中分析物浓度的信息。

    Biosensor
    14.
    发明授权
    Biosensor 失效
    生物传感器

    公开(公告)号：US06740215B1

    公开(公告)日：2004-05-25

    申请号：US09959571

    申请日：2001-10-30

    申请人： Takahiro Nakaminami ,  Motokazu Watanabe ,  Shin Ikeda ,  Shiro Nankai

    发明人： Takahiro Nakaminami ,  Motokazu Watanabe ,  Shin Ikeda ,  Shiro Nankai

    IPC分类号： G01N27327

    CPC分类号： C12Q1/005

    摘要： A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron mediator, wherein the reagent system further comprises a substance having a function to convert an organic product generated by direct reaction of a substrate to be measured with the oxidoreductase to another compound.

    摘要翻译： 一种生物传感器，包括电绝缘基板，包含工作电极的电极系统和设置在基板上的对电极，以及至少包含氧化还原酶，亲水性聚合物和电子介体的试剂系统，其中所述试剂系统还包括 具有将待测基质与氧化还原酶直接反应产生的有机产物转化为其他化合物的功能的物质。

    Method for analyzing a biological sample
    15.
    发明授权
    Method for analyzing a biological sample 有权
    分析生物样品的方法

    公开(公告)号：US06699382B2

    公开(公告)日：2004-03-02

    申请号：US10235451

    申请日：2002-09-04

    申请人： Toshihiko Yoshioka ,  Shin Ikeda ,  Motokazu Watanabe ,  Shiro Nankai

    发明人： Toshihiko Yoshioka ,  Shin Ikeda ,  Motokazu Watanabe ,  Shiro Nankai

    IPC分类号： G01N27327

    CPC分类号： C12Q1/001

    摘要： A biosensor enabling accurate measurement of the concentration of a substrate contained in a trace amount of a sample solution is disclosed. The electrochemical analysis element in accordance with the present invention which should be included in the biosensor comprises a sensor body having a hollow space which space is open at its both ends, an electrode system having a working electrode and a counter electrode, a reagent segment containing an enzyme, wherein the electrode system and the reagent segment are disposed on an inner wall of the hollow space.

    摘要翻译： 公开了能够精确测量微量样品溶液中所含的基板的浓度的生物传感器。 应包括在生物传感器中的根据本发明的电化学分析元件包括具有中空空间的传感器本体，其两端开放空间，具有工作电极和对电极的电极系统，含有 酶，其中电极系统和试剂段设置在中空空间的内壁上。

    Cholesterol sensor containing electrodes, cholesterol dehydrogenase, nicotinamide adenine dinucleotide and oxidized electron mediator
    16.
    发明授权
    Cholesterol sensor containing electrodes, cholesterol dehydrogenase, nicotinamide adenine dinucleotide and oxidized electron mediator 失效
    胆固醇传感器含有电极，胆固醇脱氢酶，烟酰胺腺嘌呤二核苷酸和氧化电子介体

    公开(公告)号：US06214612B1

    公开(公告)日：2001-04-10

    申请号：US08806801

    申请日：1997-03-03

    申请人： Tomohiro Yamamoto ,  Shin Ikeda ,  Toshihiko Yoshioka ,  Shiro Nankai ,  Junko Iwata

    发明人： Tomohiro Yamamoto ,  Shin Ikeda ,  Toshihiko Yoshioka ,  Shiro Nankai ,  Junko Iwata

    IPC分类号： C12M134

    CPC分类号： C12Q1/005 ,  Y10S435/817

    摘要： A cholesterol sensor for quantitative determination of cholesterol is provided containing an electrode system and a reaction reagent system. The electrode system contains a measuring electrode such as a carbon electrode and a counter electrode, and the reaction reagent system contains cholesterol dehydrogenase, nicotinamide adenine dinucleotide and an oxidized electron mediator. Electron mediators include ferricyanide, 1,2-naphthoquinone-4-sulfonate, 2,6-dichlorophenol indophenol, dimethylbenzoquinone, 1-methoxy-5-methylphenazinium sulfate, methylene blue, gallocyanine, thionine, phenazine methosulfate and Meldola's blue. Diaphorase, cholesterol esterase and a surfactant may also be present. The electrode system is on an insulating base plate, and the base plate has a covering member containing a groove that is a sample supplying channel which extends from an end of the base plate to the electrode system. A reaction layer containing the reagent system in dry form and a layer of a hydrophilic polymer is provided on the base plate or the covering member, or on both the electrode system and covering member so as to be exposed to the sample supplying channel. During operation, the electron mediator is reduced in conjunction with oxidation of cholesterol in a sample by cholesterol dehydrogenase, and an amount of current required to electrochemically re-oxidize the electron mediator is directly proportional to a quantity of cholesterol present in the sample.

    摘要翻译： 提供了用于定量测定胆固醇的胆固醇传感器，其包含电极系统和反应试剂系统。 电极系统含有碳电极和对电极等测定电极，反应试剂系统含有胆固醇脱氢酶，烟酰胺腺嘌呤二核苷酸和氧化电子介体。 电子介体包括铁氰化物，1,2-萘醌-4-磺酸盐，2,6-二氯苯酚靛酚，二甲基苯并醌，1-甲氧基-5-甲基吩嗪鎓硫酸盐，亚甲基蓝，花青素，硫堇，吩嗪甲硫酸盐和梅尔多拉蓝。 也可以存在心律变性酶，胆固醇酯酶和表面活性剂。 电极系统在绝缘基板上，基板具有包含作为从基板的端部延伸到电极系统的样品供给路径的槽的覆盖部件。 含有干式试剂体系和亲水性聚合物层的反应层设置在基板或覆盖部件上，或电极系统和覆盖部件上，以暴露于样品供应通道。 在操作期间，电子介体与胆固醇脱氢酶在样品中的胆固醇氧化一起被还原，并且电化学再氧化电子介体所需的电流量与样品中存在的胆固醇量成正比。

    Biosensor
    19.
    发明授权
    Biosensor 失效
    生物传感器

    公开(公告)号：US07056425B2

    公开(公告)日：2006-06-06

    申请号：US10469522

    申请日：2002-11-12

    申请人： Miwa Hasegawa ,  Tomohiro Yamamoto ,  Shin Ikeda ,  Toshihiko Yoshioka

    发明人： Miwa Hasegawa ,  Tomohiro Yamamoto ,  Shin Ikeda ,  Toshihiko Yoshioka

    IPC分类号： G01N27/327

    CPC分类号： G01N33/5438 ,  C12Q1/001

    摘要： To provide an improved biosensor which allows easy addition of whole blood to the sensor and rapid supply of the added whole blood to a filter even in the case of collecting blood by fingertip centesis for measurement, a second air aperture is provided in a sample solution supply pathway including an electrode system and a reaction layer and communicating with a first air aperture on the terminal end side.

    摘要翻译： 为了提供一种改进的生物传感器，即使在用于测量的指尖中心收集血液的情况下，也可以容易地将全血添加到传感器中并将添加的全血快速供应到过滤器，在样品溶液供应中提供第二空气孔 路径，其包括电极系统和反应层，并且与终端侧的第一空气孔连通。

    Biosensor
    20.
    发明授权
    Biosensor 失效
    生物传感器

    公开(公告)号：US06977032B2

    公开(公告)日：2005-12-20

    申请号：US10472075

    申请日：2002-11-12

    申请人： Miwa Hasegawa ,  Tomohiro Yamamoto ,  Shin Ikeda ,  Toshihiko Yoshioka

    发明人： Miwa Hasegawa ,  Tomohiro Yamamoto ,  Shin Ikeda ,  Toshihiko Yoshioka

    IPC分类号： C12Q1/00 ,  G01N33/49 ,  G01N27/327

    CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/491

    摘要： A biosensor including an insulating base plate, an electrode system, a cover for covering the insulating base plate, at least one reaction layer, a sample solution supply pathway communicating with an air aperture at a terminal end side, a sample solution supply part and a filter provided between the sample solution supply pathway and the sample solution supply part to filter hemocytes, an end face and a top face of a primary portion of the filter are exposed and the sample solution supply part is provided adjacently to the primary side portion so as to provide an improved biosensor which allows easy addition of whole blood to the sensor and rapid supply of the added whole blood to a filter even in the case of collecting blood by fingertip centesis for measurement.

    摘要翻译： 一种生物传感器，包括绝缘基板，电极系统，用于覆盖绝缘基板的盖，至少一个反应层，与终端侧的空气孔连通的样品溶液供给路径，样品溶液供给部和 提供在样品溶液供应通道和样品溶液供应部分之间以过滤血细胞的过滤器，暴露过滤器的主要部分的端面和顶面，并且将样品溶液供应部分设置成与初级侧部分相邻，以便 提供改进的生物传感器，其允许容易地将全血添加到传感器，并且即使在通过指尖中心收集血液用于测量的情况下将添加的全血快速供应到过滤器。