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公开(公告)号：US5001058A
公开(公告)日：1991-03-19
申请号：US437728
申请日：1989-11-17
申请人： Masataka Konishi , Keiko Shimizu , Masaru Ohbayashi , Koji Tomita , Takeo Miyaki , Toshikazu Oki
发明人： Masataka Konishi , Keiko Shimizu , Masaru Ohbayashi , Koji Tomita , Takeo Miyaki , Toshikazu Oki
IPC分类号： C07D311/78
CPC分类号： C07D311/78 , Y10S435/856
摘要： A new antibiotic having the chromophore structure of the plurmycin family of antibiotics is produced by fermentation of Streptomyces violaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the growth of tumors in experimental animal systems.
摘要翻译： 具有抗生素多霉素家族发生染色结构的新抗生素通过Streptomyces violaceus ATCC 53807的发酵产生。命名为BU-3839T的新型抗生素显示出有效的抗菌活性并且还抑制实验动物系统中肿瘤的生长。
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12.发明授权Biological pure culture of Streptomyces violaceus ATCC 53807 失效Streptomyces violaceus ATCC 53807的生物纯培养物
公开(公告)号：US4992376A
公开(公告)日：1991-02-12
申请号：US555888
申请日：1990-07-23
申请人： Masataka Konishi , Keiko Shimizu , Masaru Ohbayashi , Koji Tomita , Takeo Miyaki , Toshikazu Oki
发明人： Masataka Konishi , Keiko Shimizu , Masaru Ohbayashi , Koji Tomita , Takeo Miyaki , Toshikazu Oki
IPC分类号： C07D311/78
CPC分类号： C07D311/78 , Y10S435/886
摘要： An new antibiotic having the chromophore structure of the pluramycin family of antibiotics is produced by fermentation of Streptomyces violaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the growth of tumors in experimental animal systems.
摘要翻译： 具有抗生素普拉霉素家族的发色团结构的新型抗生素通过Streptomyces violaceus ATCC 53807的发酵产生。命名为BU-3839T的新型抗生素显示出有效的抗菌活性并且也抑制实验动物系统中肿瘤的生长。
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公开(公告)号：US4935362A
公开(公告)日：1990-06-19
申请号：US31955
申请日：1987-03-30
IPC分类号： C07D487/04 , C12P17/18
CPC分类号： C07D487/04 , C12P17/182 , C12R1/47 , Y10S435/887
摘要： A new antitumor antibiotic designated herein as BMY-28121 is produced by fermentation of Streptomyces albus strain K7331-113 (ATCC 39897). BMY-28121, which may be recovered from the fermentation broth in either its natural free hydroxy form (BMY-28121A) or methyl ether form (BMY-28121B), inhibits gram-positive bacteria and anaerobes and inhibits the growth of mammalian tumors such as P-388 leukemia, L-1210 leukemia and B16 melanoma.
摘要翻译： 本文命名为BMY-28121的新抗肿瘤抗生素是通过发酵链霉菌株K7331-113（ATCC 39897）产生的。 可以从其天然游离羟基形式（BMY-28121A）或甲基醚形式（BMY-28121B）的发酵液中回收的BMY-28121抑制革兰氏阳性菌和厌氧菌，并抑制哺乳动物肿瘤的生长，例如 P-388白血病，L-1210白血病和B16黑素瘤。
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公开(公告)号：US4683230A
公开(公告)日：1987-07-28
申请号：US704973
申请日：1985-02-25
IPC分类号： C07D487/04 , C12P17/18 , A61K31/55
CPC分类号： C07D487/04 , C12P17/182 , C12R1/47
摘要： A new antitumor antibiotic designated herein as BMY-28121 is produced by fermentation of Streptomyces albus strain K731-113 (ATCC 39897). BMY-28121, which may be recovered from the fermentation broth in either its natural free hydroxy form (BMY-28121A) or methyl ether form (BMY-28121B), inhibits gram-positive bacteria and anaerobes and inhibits the growth of mammalian tumors such as P-388 leukemia, L-1210 leukemia and B16 melanoma.
摘要翻译： 本文命名为BMY-28121的新型抗肿瘤抗生素通过Streptomyces albus菌株K731-113（ATCC 39897）的发酵产生。 可以从其天然游离羟基形式（BMY-28121A）或甲基醚形式（BMY-28121B）的发酵液中回收的BMY-28121抑制革兰氏阳性菌和厌氧菌，并抑制哺乳动物肿瘤的生长，例如 P-388白血病，L-1210白血病和B16黑素瘤。
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公开(公告)号：US5096817A
公开(公告)日：1992-03-17
申请号：US627669
申请日：1990-12-14
申请人： Maki Nishio , Yosuke Sawada , Takeo Miyaki , Toshikazu Oki
发明人： Maki Nishio , Yosuke Sawada , Takeo Miyaki , Toshikazu Oki
IPC分类号： C07H15/244 , C12P19/56
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56 , Y10S435/825
摘要： Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.
摘要翻译： 本文公开了从放线菌（Actinomadura hibisca）分离的抗生素BU-3608D和E。 这些化合物是活性抗真菌剂。
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16.发明授权Method for treating fungal infections with serine analogs of BU-3608 antibiotics 失效用BU-3608抗生素丝氨酸类似物治疗真菌感染的方法
公开(公告)号：US5183808A
公开(公告)日：1993-02-02
申请号：US837718
申请日：1992-02-19
申请人： Yosuke Sawada , Masatoshi Kakushima , Maki Nishio , Takeo Miyaki , Toshikazu Oki
发明人： Yosuke Sawada , Masatoshi Kakushima , Maki Nishio , Takeo Miyaki , Toshikazu Oki
IPC分类号： C07H15/244 , C12P19/56
CPC分类号： C12P19/56 , C07H15/244
摘要： Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
摘要翻译： 公开了抗生素BU-3608FA-1和FA-2及其烷基衍生物。 这些化合物可用作抗真菌剂。 BU-3608 FA-1和FA-2由含有D-丝氨酸源的培养基中的放线菌（Ininomadura hibisca）生产。
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公开(公告)号：US5061624A
公开(公告)日：1991-10-29
申请号：US569679
申请日：1990-08-20
申请人： Yosuke Sawada , Masatoshi Kakushima , Maki Nishio , Takeo Miyaki , Toshikazu Oki
发明人： Yosuke Sawada , Masatoshi Kakushima , Maki Nishio , Takeo Miyaki , Toshikazu Oki
IPC分类号： C07H15/244 , C12P19/56
CPC分类号： C12P19/56 , C07H15/244 , Y10S435/825
摘要： Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
摘要翻译： 公开了抗生素BU-3608FA-1和FA-2及其烷基衍生物。 这些化合物可用作抗真菌剂。 BU-3608 FA-1和FA-2由含有D-丝氨酸源的培养基中的放线菌（Ininomadura hibisca）生产。
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18.发明授权Actinomadura hibisca microorganism useful for preparing serine analogs of BU-3608 antibiotics 失效用于制备BU-3608抗生素丝氨酸类似物的Actinomadura hibisca微生物
公开(公告)号：US5114857A
公开(公告)日：1992-05-19
申请号：US699548
申请日：1991-05-14
申请人： Yosuke Sawada , Masatoshi Kakushima , Maki Nishio , Takeo Miyaki , Toshikazu Oki
发明人： Yosuke Sawada , Masatoshi Kakushima , Maki Nishio , Takeo Miyaki , Toshikazu Oki
IPC分类号： C07H15/244 , C12P19/56
CPC分类号： C12P19/56 , C07H15/244 , Y10S435/825
摘要： Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
摘要翻译： 公开了抗生素BU-3608FA-1和FA-2及其烷基衍生物。 这些化合物可用作抗真菌剂。 BU-3608 FA-1和FA-2由含有D-丝氨酸源的培养基中的放线菌（Ininomadura hibisca）生产。
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公开(公告)号：US4992425A
公开(公告)日：1991-02-12
申请号：US203776
申请日：1988-06-07
申请人： Maki Nishio , Yosuke Sawada , Takeo Miyaki , Toshikazu Oki
发明人： Maki Nishio , Yosuke Sawada , Takeo Miyaki , Toshikazu Oki
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P31/10 , C07H15/24 , C07H15/244 , C12P19/56 , C12R1/03 , A61K31/71
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56 , Y10S435/825
摘要： Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.
摘要翻译： 本文公开了从放线菌（Actinomadura hibisca）分离的抗生素BU-3608D和E。 这些化合物是活性抗真菌剂。
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公开(公告)号：US4973673A
公开(公告)日：1990-11-27
申请号：US269821
申请日：1988-11-10
申请人： Yosuke Sawada , Masatoshi Kakushima , Maki Nishio , Takeo Miyaki , Toshikazu Oki
发明人： Yosuke Sawada , Masatoshi Kakushima , Maki Nishio , Takeo Miyaki , Toshikazu Oki
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P31/10 , C07H15/24 , C07H15/244 , C12N1/20 , C12P19/56 , C12R1/03
CPC分类号： C07H15/244 , C12P19/56
摘要： Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
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