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19 条记录 (耗时 0.026 秒)

    Abuse-resistant amphetamine compounds
    12.
    发明申请
    Abuse-resistant amphetamine compounds 有权
    滥用安非他明类化合物

    公开(公告)号：US20050054561A1

    公开(公告)日：2005-03-10

    申请号：US10858526

    申请日：2004-06-01

    申请人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    发明人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    IPC分类号： A61K31/165 ,  A61K31/7008 ,  A61K38/16 ,  A61K47/48 ,  A61K48/00

    CPC分类号： A61K31/165 ,  A61K47/542

    摘要： The invention describes compounds, compositions and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

    摘要翻译： 本发明描述了使用其的化合物，组合物和方法，其包含与苯丙胺共价连接的化学部分。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。

    Abuse resistant lysine amphetamine compounds
    13.
    发明申请
    Abuse resistant lysine amphetamine compounds 有权
    滥用抗性赖氨酸苯丙胺化合物

    公开(公告)号：US20050038121A1

    公开(公告)日：2005-02-17

    申请号：US10857619

    申请日：2004-06-01

    申请人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    发明人： Travis Mickle ,  Suma Krishnan ,  Barney Bishop ,  Christopher Lauderback ,  James Moncrief ,  Rob Oberlender ,  Thomas Piccariello

    IPC分类号： A61K31/165 ,  A61K31/198 ,  A61K38/00 ,  A61K47/48

    CPC分类号： A61K31/165 ,  A61K47/542 ,  C07C237/06 ,  Y02A50/415 ,  Y10S436/901 ,  Y10T436/173845

    摘要： The present invention describes compounds, compositions and methods of using the same comprising lysine covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.

    摘要翻译： 本发明描述了使用其包含与苯丙胺共价连接的赖氨酸的化合物，组合物和方法。 这些化合物和组合物可用于减少或预防滥用和过量安非他明。 这些化合物和组合物特别用于提供某些障碍（例如注意力缺陷多动障碍（ADHD），ADD，发作性睡病和肥胖）的耐药性替代治疗。 苯丙胺的口服生物利用度维持在治疗有用的剂量。 在较高剂量下，生物利用度显着降低，从而提供减少口服滥用责任的方法。 此外，本发明的化合物和组合物通过肠胃外途径（例如静脉内或鼻内给药）降低苯丙胺的生物利用度，进一步限制其滥用责任。

    Carbohydrate conjugates to prevent abuse of controlled substances
    14.
    发明申请
    Carbohydrate conjugates to prevent abuse of controlled substances 有权
    碳水化合物缀合物，以防止受控物质的滥用

    公开(公告)号：US20070197451A1

    公开(公告)日：2007-08-23

    申请号：US11179801

    申请日：2005-07-13

    申请人： Travis Mickle ,  Thomas Piccariello ,  James Moncrief ,  Nancy Boerth ,  Barney Bishop

    发明人： Travis Mickle ,  Thomas Piccariello ,  James Moncrief ,  Nancy Boerth ,  Barney Bishop

    IPC分类号： A61K31/485 ,  A61K9/22

    CPC分类号： A61K9/0019 ,  A61K31/706 ,  A61K47/549

    摘要： The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.

    摘要翻译： 本发明提供了一种“街道安全”的受控物质版本，其允许物质的治疗有益效果，同时减少或消除导致药物滥用的欣快效应。 本发明提供药物组合物，其包含受控物质和与所述受控物质共价结合的碳水化合物，使得所述受控物质在药理学上无活性或显着降低其活性及其使用方法。

    System and Software of Enhanced Pharmaceutical Operations in Long-Term Care Facilities and Related Methods
    16.
    发明申请
    System and Software of Enhanced Pharmaceutical Operations in Long-Term Care Facilities and Related Methods 有权
    长期护理设施加强药物运作的制度与软件及相关方法

    公开(公告)号：US20080091467A1

    公开(公告)日：2008-04-17

    申请号：US11951050

    申请日：2007-12-05

    申请人： James Moncrief ,  James Martin

    发明人： James Moncrief ,  James Martin

    IPC分类号： G06Q50/00

    CPC分类号： G06F19/3462 ,  B65B1/30 ,  G06F19/00 ,  G06F19/328 ,  G06F19/3418 ,  G06F19/3456 ,  G06Q10/08 ,  G06Q40/08 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  G16H40/20

    摘要： A system, pharmacy management software, and related methods of enhanced pharmaceutical operations in patient care facilities are provided. The pharmacy management software, for example, can include instructions that when executed by a computer, cause the computer to perform the operations of providing instructions to pharmaceutical storage and electronic dispensing carts positioned at various patient care facilities according to patient specific prescription requirements, receiving dispensing data from each of the carts, and providing separate billing records including billing data indexed by reimbursement provider for each patient at the patient care facilities. The operations can also include consolidating the billing data by patient, by patient care facility, by remote pharmacy, and/or consolidating billing data by reimbursement provider, and submitting separate consolidated reimbursement claims electronically to each respective reimbursement provider.

    摘要翻译： 提供了一种系统，药房管理软件以及病人护理设施中增强药物操作的相关方法。 例如，药房管理软件可以包括当由计算机执行时指示，使得计算机根据患者特定处方要求执行向定位在各种病人护理设施处的药物储存和电子分配车提供指令的操作， 来自每个购物车的数据，并且提供单独的记帐记录，包括由患者护理设施处的每个患者的报销提供者索引的计费数据。 这些操作还可以包括由患者，患者护理设施，远程药房合并计费数据，和/或通过报销提供者整合计费数据，并以电子方式向每个相应的报销提供者提交单独的综合报销索赔。

    ABUSE-RESISTANT HYDROCODONE COMPOUNDS, COMPOSITIONS AND METHODS OF USING THE SAME
    17.
    发明申请
    ABUSE-RESISTANT HYDROCODONE COMPOUNDS, COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
    耐药氢醌化合物，组合物及其使用方法

    公开(公告)号：US20080090771A1

    公开(公告)日：2008-04-17

    申请号：US11868636

    申请日：2007-10-08

    申请人： James Moncrief

    发明人： James Moncrief

    IPC分类号： A61K31/4355 ,  A61K38/05 ,  A61K38/06 ,  A61K38/08 ,  A61P25/00 ,  C07D471/04 ,  C07K5/062 ,  C07K5/083 ,  C07K7/06

    CPC分类号： C07K5/1021 ,  A61K38/00 ,  A61K47/65 ,  C07D489/02 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0819 ,  C07K5/0823 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1019 ,  C07K5/1024 ,  C07K7/06 ,  C07K9/001

    摘要： The invention relates to compounds, compositions and methods comprised of a chemical moiety attached to hydrocodone. The invention provides embodiments that provide a decrease in the potential of hydrocodone to cause overdose or to be abused while still delivering therapeutic activity similar to that of the parent hydrocodone. The invention also provides methods of delivering hydrocodone as conjugates that release the hydrocodone following oral administration while being resistant to abuse by other routes such as intravenous injection (“shooting”) and intranasal administration (“snorting”). Further, hydrocodone compositions of the invention are resistant to oral abuse as well, since release of the hydrocodone at suprapharmacological doses reaches saturation.

    摘要翻译： 本发明涉及包含与氢可酮相连的化学部分的化合物，组合物和方法。 本发明提供的实施方案提供了氢可酮的潜力降低以引起过量或被滥用，同时仍然提供与母体氢可酮类似的治疗活性。 本发明还提供了递送氢可酮作为共轭物的方法，其在口服给药之后释放氢可酮，同时抗其他途径例如静脉内注射（“射击”）和鼻内给药（“鼻吸”）的滥用。 此外，本发明的氢可酮组合物也耐口服滥用，因为以超药物剂量的氢可酮的释放达到饱和。

    System and software of enhanced pharmaceutical operations in long-term care facilities and related methods
    18.
    发明申请
    System and software of enhanced pharmaceutical operations in long-term care facilities and related methods 有权
    长期护理设施加强制药业务的制度和软件及相关方法

    公开(公告)号：US20050096785A1

    公开(公告)日：2005-05-05

    申请号：US10944993

    申请日：2004-09-20

    申请人： James Moncrief ,  James Martin

    发明人： James Moncrief ,  James Martin

    IPC分类号： G06F17/00

    CPC分类号： G06F19/3462 ,  B65B1/30 ,  G06F19/00 ,  G06F19/328 ,  G06F19/3418 ,  G06F19/3456 ,  G06Q10/08 ,  G06Q40/08 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  G16H40/20

    摘要： A system, software and related methods of enhanced pharmaceutical operations in long term care facilities are provided. An embodiment of a system includes a long-term care facility pharmacy group management server, long-term care facility pharmacy management software associated with the long-term care facility pharmacy group management server to manage pharmacological operations in a plurality of long-term care facilities, a plurality of pharmaceutical storage and electronic dispensing carts each positioned in a long-term care facility remote from the long-term care facility pharmacy group management server and in communication therewith, a remote pharmacy group server in communication with the long-term care facility pharmacy group management server, and a plurality of pharmaceutical prescription document processors each positioned in a long-term care facility and in communication with the remote pharmacy group server or the long-term care facility pharmacy group management server.

    摘要翻译： 提供了长期护理设施中增强药物操作的系统，软件和相关方法。 系统的实施例包括长期护理设施药房组管理服务器，与长期护理设施药房组管理服务器相关联的长期护理设施药房管理软件，用于管理多个长期护理设施中的药理作用 ，多个药物储存和电子分配车，每个药物储存和电子分配车每个定位在远离护理设施药房组管理服务器的远程护理设施中，并与之通信，与长期护理设施通信的远程药房组服务器 药剂组管理服务器和多个处方文件处理器，每个处理文件处理器分别位于长期护理设施中并与远程药房组服务器或长期护理设施药房组管理服务器通信。

    System and software of enhanced pharmaceutical operations in long-term care facilities and related methods
    19.
    发明申请
    System and software of enhanced pharmaceutical operations in long-term care facilities and related methods 有权
    长期护理设施加强制药业务的制度和软件及相关方法

    公开(公告)号：US20070250210A1

    公开(公告)日：2007-10-25

    申请号：US11818416

    申请日：2007-06-14

    申请人： James Moncrief ,  James Martin

    发明人： James Moncrief ,  James Martin

    IPC分类号： G06F17/00

    CPC分类号： G06F19/3462 ,  B65B1/30 ,  G06F19/00 ,  G06F19/328 ,  G06F19/3418 ,  G06F19/3456 ,  G06Q10/08 ,  G06Q40/08 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  G16H40/20

    摘要： A system, software and related methods of enhanced pharmaceutical operations in long term care facilities are provided. An embodiment of a system includes a long-term care facility pharmacy group management server, long-term care facility pharmacy management software associated with the long-term care facility pharmacy group management server to manage pharmacological operations in a plurality of long-term care facilities, a plurality of pharmaceutical storage and electronic dispensing carts each positioned in a long-term care facility remote from the long-term care facility pharmacy group management server and in communication therewith, a remote pharmacy group server in communication with the long-term care facility pharmacy group management server, and a plurality of pharmaceutical prescription document processors each positioned in a long-term care facility and in communication with the remote pharmacy group server or the long-term care facility pharmacy group management server.

    摘要翻译： 提供了长期护理设施中增强药物操作的系统，软件和相关方法。 系统的实施例包括长期护理设施药房组管理服务器，与长期护理设施药房组管理服务器相关联的长期护理设施药房管理软件，用于管理多个长期护理设施中的药理作用 ，多个药物储存和电子分配车，每个药物储存和电子分配车每个定位在远离护理设施药房组管理服务器的远程护理设施中，并与之通信，与长期护理设施通信的远程药房组服务器 药剂组管理服务器和多个处方文件处理器，每个处理文件处理器分别位于长期护理设施中并与远程药房组服务器或长期护理设施药房组管理服务器通信。