公开(公告)号：US20250064730A1

公开(公告)日：2025-02-27

申请号：US18941158

申请日：2024-11-08

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Russell Macoon

IPC: A61K9/06 ,  A61K9/00 ,  A61K31/5377 ,  A61K47/10 ,  A61K47/12 ,  A61K47/38 ,  A61K47/44

Abstract: In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US12156850B2

公开(公告)日：2024-12-03

申请号：US17231233

申请日：2021-04-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01J20/26 ,  B01J20/28 ,  A61K9/00 ,  A61K9/08 ,  A61K31/498 ,  A61K31/5377 ,  A61K47/18 ,  B01D15/00

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20230404947A1

公开(公告)日：2023-12-21

申请号：US18237920

申请日：2023-08-25

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon

IPC: A61K31/145 ,  A61K47/42 ,  A45C11/00 ,  A61K9/00 ,  A61F9/00 ,  A61K47/22

CPC classification number: A61K31/145 ,  A61K47/42 ,  A45C11/005 ,  A61K9/0048 ,  A61F9/0008 ,  A61K47/22

Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.

公开(公告)号：US20220378610A1

公开(公告)日：2022-12-01

申请号：US17769922

申请日：2020-11-12

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Russell Macoon ,  Keith G. Christopher

IPC: A61F9/00 ,  A61M5/20 ,  A61K31/5377 ,  A61K9/06

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure relates to an auto-injector device that can be used for injection of ophthalmological formulations. The auto-injector device can function in two stages, where a lubricious material is released in a first stage and a drug delivery composition is released in a second stage. The present disclosure provides for method of using these injector devices.

公开(公告)号：US11051976B2

公开(公告)日：2021-07-06

申请号：US16166787

申请日：2018-10-22

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Kuan-Hui Hsu

IPC: A61F9/00 ,  A61J1/05 ,  A61J1/14 ,  A61K9/00 ,  A61K31/382 ,  A61K31/5377 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/18 ,  B01D15/00 ,  B01J20/26 ,  C08J9/28 ,  B65D51/24

Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

公开(公告)号：US11033457B2

公开(公告)日：2021-06-15

申请号：US16388470

申请日：2019-04-18

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01J20/26 ,  B01J20/28 ,  A61K9/00 ,  A61K9/08 ,  A61K31/498 ,  A61K31/5377 ,  A61K47/18 ,  B01D15/00

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US09885886B2

公开(公告)日：2018-02-06

申请号：US15447820

申请日：2017-03-02

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Hyun-Jung Jung ,  Samuel B. Gause

IPC: G02C7/08 ,  G02C7/10 ,  G02C7/04 ,  B29D11/00 ,  B29K83/00

CPC classification number: G02C7/108 ,  B29D11/00038 ,  B29D11/00346 ,  B29D11/00634 ,  B29K2083/00 ,  B82Y20/00 ,  B82Y30/00 ,  G02B1/043 ,  G02C7/049 ,  Y10S977/834 ,  Y10T428/2982 ,  C08L101/14 ,  C08L33/08 ,  C08L33/26 ,  C08L33/10

Abstract: UV absorbing appliances, such as contact lenses, are prepared by including at least one UV absorbing compound in the appliances. UV absorbing compounds can be water insoluble and/or reside in UV absorbing nanoparticles having a mean diameter less than 10 nm. The UV absorbing nanoparticles incorporate into an appliance by polymerizing a monomer mixture containing the UV absorbing nanoparticles to form an appliance comprising the UV absorbing nanoparticles. The UV absorbing compounds or the UV absorbing nanoparticles incorporate into an appliance by placing the appliance in a solution of the UV absorbing compound or a dispersion of the UV absorbing nanoparticles in a non-aqueous solvent that swells the appliance. The UV absorbing compound or the UV absorbing nanoparticles infuse into the swollen appliance and are retained within the appliance upon removal of the non-aqueous solvent.

公开(公告)号：US20170212365A1

公开(公告)日：2017-07-27

申请号：US15447820

申请日：2017-03-02

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Hyun-Jung Jung ,  Samuel B. Gause

IPC: G02C7/10 ,  B29D11/00 ,  G02C7/04

CPC classification number: G02C7/108 ,  B29D11/00038 ,  B29D11/00346 ,  B29D11/00634 ,  B29K2083/00 ,  B82Y20/00 ,  B82Y30/00 ,  G02B1/043 ,  G02C7/049 ,  Y10S977/834 ,  Y10T428/2982 ,  C08L101/14 ,  C08L33/08 ,  C08L33/26 ,  C08L33/10

Abstract: UV absorbing appliances, such as contact lenses, are prepared by including at least one UV absorbing compound in the appliances. UV absorbing compounds can be water insoluble and/or reside in UV absorbing nanoparticles having a mean diameter less than 10 nm. The UV absorbing nanoparticles incorporate into an appliance by polymerizing a monomer mixture containing the UV absorbing nanoparticles to form an appliance comprising the UV absorbing nanoparticles. The UV absorbing compounds or the UV absorbing nanoparticles incorporate into an appliance by placing the appliance in a solution of the UV absorbing compound or a dispersion of the UV absorbing nanoparticles in a non-aqueous solvent that swells the appliance. The UV absorbing compound or the UV absorbing nanoparticles infuse into the swollen appliance and are retained within the appliance upon removal of the non-aqueous solvent.

公开(公告)号：US11828915B2

公开(公告)日：2023-11-28

申请号：US17929349

申请日：2022-09-02

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Kuan-Hui Hsu ,  Yifan Yu

IPC: G02B1/18 ,  C08J3/28 ,  G02B1/04

CPC classification number: G02B1/18 ,  C08J3/28 ,  G02B1/043 ,  C08J2377/00 ,  C08J2383/04

Abstract: In one aspect, the present disclosure relates to a contact lens comprising a disclosed lubricious surface layer. In a further aspect, the lubricious surface layer comprises a polyacrylamide, e.g., a poly(N,N-dimethylacrylamide. In various aspects, the lubricious surface layer is formed at the surface of a contact lens. In a further aspect, the lens can be a hydrogel lens. In a further aspect, the lens can be a silicone hydrogel lens. The present disclosure also pertains to methods of forming the disclosed lubricious surface layers on a surface of a contact lens. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11826974B2

公开(公告)日：2023-11-28

申请号：US17647859

申请日：2022-01-13

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: B29D11/00 ,  G02C7/04

CPC classification number: B29D11/00903 ,  B29D11/00038 ,  G02C7/04

Abstract: In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or pokorny woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.