公开(公告)号：US12077758B2

公开(公告)日：2024-09-03

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O′Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/11 ,  C12N15/113

CPC classification number: C12N15/1131 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20230078622A1

公开(公告)日：2023-03-16

申请号：US17846526

申请日：2022-06-22

Applicant: UNIVERSITY OF MASSACHUSETTS ,  BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

Inventor： Anastasia Khvorova ,  Vignesh Narayan Hariharan ,  Sarah Davis ,  Annabelle Biscans ,  Ananth Karumanchi

IPC: C12N15/113 ,  A61P7/00

Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.

公开(公告)号：US20220251555A1

公开(公告)日：2022-08-11

申请号：US17580269

申请日：2022-01-20

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Julia Alterman ,  Sarah Davis ,  Anton Turanov

IPC: C12N15/113

Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.

公开(公告)号：US20210363523A1

公开(公告)日：2021-11-25

申请号：US17204480

申请日：2021-03-17

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Chantal Ferguson ,  Sarah Davis ,  Kathryn Monopoli

IPC: C12N15/113

Abstract: This disclosure relates to novel MAPT targeting sequences. Novel MAPT targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.

公开(公告)号：US20200087663A1

公开(公告)日：2020-03-19

申请号：US16550076

申请日：2019-08-23

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Julia Alterman ,  Sarah Davis ,  Anton Turanov

IPC: C12N15/113

Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.