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公开(公告)号：US20240173420A1
公开(公告)日：2024-05-30
申请号：US18375206
申请日：2023-09-29
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Claudio Punzo , Anastasia Khvorova , Dimas Echeverria Moreno , Annabelle Biscans , Julia F. Alterman , Matthew Hassler , Shun-Yun Cheng
CPC classification number: A61K47/554 , A61K9/0048 , A61K47/542 , A61K47/543 , A61K47/545 , A61K47/548
Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific eye distribution.
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2.发明公开公开(公告)号：US20240067967A1
公开(公告)日：2024-02-29
申请号：US18321971
申请日：2023-05-23
Inventor： Anastasia Khvorova , Vignesh Narayan Hariharan , Sarah Davis , Annabelle Biscans , Ananth Karumanchi
IPC: C12N15/113 , A61P9/12
CPC classification number: C12N15/113 , A61P9/12 , C12N2310/11 , C12N2310/312 , C12N2310/315 , C12N2310/321
Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
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公开(公告)号：US11702659B2
公开(公告)日：2023-07-18
申请号：US17846526
申请日：2022-06-22
Inventor： Anastasia Khvorova , Vignesh Narayan Hariharan , Sarah Davis , Annabelle Biscans , Ananth Karumanchi
IPC: C07H21/04 , C12N15/113 , A61P7/00
CPC classification number: C12N15/113 , A61P7/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/346 , C12N2320/32
Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
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公开(公告)号：US20230021431A1
公开(公告)日：2023-01-26
申请号：US17333839
申请日：2021-05-28
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Jonathan Watts , Zachary Kennedy , Annabelle Biscans , Bruno Miguel da Cruz Godinho , Chantal Ferguson , Dimas Echeverria Moreno , Ken Yamada , Daniel O'Reilly , Kathryn Monopoli , Vignesh Narayan Hariharan , Qi Tang , Sarah Davis , Samuel Hildebrand , Socheata Ly , Minwook Shin , Pranathi Meda Krishnamurthy , Nicholas McHugh , Jacquelyn Sousa , Jillian Caiazzi , Yann Thillier , Gitali Devi
IPC: C12N15/113
Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
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公开(公告)号：US20240425860A1
公开(公告)日：2024-12-26
申请号：US18675670
申请日：2024-05-28
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Jonathan Watts , Zachary Kennedy , Annabelle Biscans , Bruno Miguel da Cruz Godinho , Chantal Ferguson , Dimas Echeverria Moreno , Ken Yamada , Daniel O'Reilly , Kathryn Monopoli , Vignesh Narayan Hariharan , Qi Tang , Sarah Davis , Samuel Hildebrand , Socheata Ly , Minwook Shin , Pranathi Meda Krishnamurthy , Nicholas McHugh , Jacquelyn Sousa , Jillian Caiazzi , Yann Thillier , Gitali Devi
IPC: C12N15/113
Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
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Patent Agency Ranking
公开(公告)号：US12077758B2
公开(公告)日：2024-09-03
申请号：US17333839
申请日：2021-05-28
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Jonathan Watts , Zachary Kennedy , Annabelle Biscans , Bruno Miguel da Cruz Godinho , Chantal Ferguson , Dimas Echeverria Moreno , Ken Yamada , Daniel O′Reilly , Kathryn Monopoli , Vignesh Narayan Hariharan , Qi Tang , Sarah Davis , Samuel Hildebrand , Socheata Ly , Minwook Shin , Pranathi Meda Krishnamurthy , Nicholas McHugh , Jacquelyn Sousa , Jillian Caiazzi , Yann Thillier , Gitali Devi
IPC: C12N15/11 , C12N15/113
CPC classification number: C12N15/1131 , C12N15/1136 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/351 , C12N2310/3515 , C12N2320/32
Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
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公开(公告)号：US20240182904A1
公开(公告)日：2024-06-06
申请号：US18375235
申请日：2023-09-29
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Claudio Punzo , Anastasia Khvorova , Dimas Echeverria Moreno , Annabelle Biscans , Julia F. Alterman , Matthew Hassler , Shun-Yun Cheng , Jillian Caiazzi
IPC: C12N15/113 , A61K47/54 , A61P27/02 , C12N15/86
CPC classification number: C12N15/1137 , A61K47/549 , A61P27/02 , C12N15/86 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2750/14122 , C12N2750/14143
Abstract: Provided herein are oligonucleotides (e.g., siRNA) targeting S6K1. Also provided are methods of treating a disease associated with S6K1 expression.
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公开(公告)号：US11753638B2
公开(公告)日：2023-09-12
申请号：US16322212
申请日：2017-08-11
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Mehran Nikan , Matthew Hassler , Maire Osborn , Reka Haraszti , Andrew Coles , Anton Turanov , Neil Aronin , Annabelle Biscans
IPC: A61K31/7088 , C12N15/113 , A61K47/54 , C07H21/02 , C07H21/04 , C07H21/00 , C12N15/11 , A61K47/55 , A61P1/16 , A61P9/00 , A61P13/12 , A61P1/00 , A61P5/00 , A61P11/00 , A61K9/00
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/7088 , A61K47/54 , A61K47/543 , A61K47/549 , A61K47/551 , A61K47/554 , A61P1/00 , A61P1/16 , A61P5/00 , A61P9/00 , A61P11/00 , A61P13/12 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N2310/14 , C12N2310/312 , C12N2310/315 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
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公开(公告)号：US20230078622A1
公开(公告)日：2023-03-16
申请号：US17846526
申请日：2022-06-22
Inventor： Anastasia Khvorova , Vignesh Narayan Hariharan , Sarah Davis , Annabelle Biscans , Ananth Karumanchi
IPC: C12N15/113 , A61P7/00
Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
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公开(公告)号：US20210108200A1
公开(公告)日：2021-04-15
申请号：US17022678
申请日：2020-09-16
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Annabelle Biscans
IPC: C12N15/113 , A61K31/713
Abstract: This disclosure relates to an siRNA-lipid conjugate of formula Y-L-(H)n. Y is an siRNA molecule, L is a linker covalently bonded to Y and H, each H is independently a hydrophobic chain comprising 5 to 50 carbon atoms, n is 1, 2, or 3, and linker L is bonded to the 3′ end of the sense strand of the siRNA.
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