公开(公告)号：US20230021431A1

公开(公告)日：2023-01-26

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O'Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/113

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20250043284A1

公开(公告)日：2025-02-06

申请号：US18760779

申请日：2024-07-01

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Chantal Ferguson ,  Sarah Davis ,  Kathryn Monopoli

IPC: C12N15/113 ,  A61K47/54 ,  A61K47/55 ,  A61K48/00

Abstract: This disclosure relates to novel SNCA targeting sequences. Novel SNCA targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.

公开(公告)号：US20210363524A1

公开(公告)日：2021-11-25

申请号：US17204483

申请日：2021-03-17

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Chantal Ferguson ,  Sarah Davis ,  Kathryn Monopoli

IPC: C12N15/113 ,  A61K47/54 ,  A61K48/00 ,  A61K47/55

Abstract: This disclosure relates to novel SNCA targeting sequences. Novel SNCA targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.

公开(公告)号：US20240425860A1

公开(公告)日：2024-12-26

申请号：US18675670

申请日：2024-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O'Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/113

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US12077758B2

公开(公告)日：2024-09-03

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O′Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/11 ,  C12N15/113

CPC classification number: C12N15/1131 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20210363523A1

公开(公告)日：2021-11-25

申请号：US17204480

申请日：2021-03-17

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Chantal Ferguson ,  Sarah Davis ,  Kathryn Monopoli

IPC: C12N15/113

Abstract: This disclosure relates to novel MAPT targeting sequences. Novel MAPT targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.