公开(公告)号：US20240401042A1

公开(公告)日：2024-12-05

申请号：US18609299

申请日：2024-03-19

Applicant: UNIVERSITY OF MASSACHUSETTS ,  MCGILL UNIVERSITY

Inventor： Hassan H. Fakih ,  Hanadi Sleiman ,  Anastasia Khvorova ,  John E. Harris ,  Qi Tang ,  Ken Okamura

IPC: C12N15/113 ,  A61K47/54 ,  A61P35/00

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to a tumor. The oligonucleotide is conjugated to a dendron comprising an end group, a phosphate group, and/or a hydrophobic chain.

公开(公告)号：US20240287514A1

公开(公告)日：2024-08-29

申请号：US18393044

申请日：2023-12-21

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  John E. Harris ,  Qi Tang

IPC: C12N15/113 ,  A61P37/00

CPC classification number: C12N15/113 ,  A61P37/00 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515

Abstract: This disclosure relates to novel IFN-γ signaling pathway target gene targeting sequences. Novel IFNGR1, JAK1, JAK2, and STAT1 targeting oligonucleotides for the treatment of vitiligo are also provided.

公开(公告)号：US20230021431A1

公开(公告)日：2023-01-26

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O'Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/113

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20240350526A1

公开(公告)日：2024-10-24

申请号：US18592943

申请日：2024-03-01

Applicant: UNIVERSITY OF MASSACHUSETTS ,  MCGILL UNIVERSITY

Inventor： Hassan H. Fakih ,  Hanadi Sleiman ,  Anastasia Khvorova ,  Qi Tang ,  Katherine Gross ,  John E. Harris ,  Julia Alterman ,  Mohammad Zain Ul Abideen ,  Raymond Furgal

IPC: A61K31/713 ,  A61K9/00 ,  A61K47/58 ,  C12N15/113

CPC classification number: A61K31/713 ,  A61K9/0014 ,  A61K47/605 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/312

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the skin. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

公开(公告)号：US20240425860A1

公开(公告)日：2024-12-26

申请号：US18675670

申请日：2024-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O'Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/113

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20240366773A1

公开(公告)日：2024-11-07

申请号：US18592676

申请日：2024-03-01

Applicant: UNIVERSITY OF MASSACHUSETTS ,  MCGILL UNIVERSITY

Inventor： Hassan H. Fakih ,  Hanadi Sleiman ,  Anastasia Khvorova ,  Jonathan K. Watts ,  Qi Tang ,  Minwook Shin

IPC: A61K47/56 ,  A61K9/00 ,  A61K31/713 ,  C12N15/113

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the lung. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

公开(公告)号：US20240325546A1

公开(公告)日：2024-10-03

申请号：US18593212

申请日：2024-03-01

Applicant: UNIVERSITY OF MASSACHUSETTS ,  MCGILL UNIVERSITY

Inventor： Hassan H. Fakih ,  Hanadi Sleiman ,  Anastasia Khvorova ,  Qi Tang ,  John E. Harris ,  Julia Alterman ,  Mohammad Zain Ul Abideen ,  Raymond Furgal

IPC: A61K47/54 ,  A61M37/00 ,  C12N15/113

CPC classification number: A61K47/549 ,  A61K47/542 ,  A61M37/0015 ,  C12N15/113 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061 ,  C12N2310/14 ,  C12N2310/351

Abstract: This disclosure provides compositions, systems, and methods for the topical delivery of therapeutic oligonucleotides with microneedle particles.

公开(公告)号：US12077758B2

公开(公告)日：2024-09-03

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O′Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/11 ,  C12N15/113

CPC classification number: C12N15/1131 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.