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公开(公告)号：US20230348907A1
公开(公告)日：2023-11-02
申请号：US18094695
申请日：2023-01-09
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Vignesh Narayan Hariharan
IPC: C12N15/113 , C12N15/86 , A61P25/28
CPC classification number: C12N15/113 , C12N15/86 , A61P25/28 , C12N2310/11 , C12N2310/32 , C12N2750/14143
Abstract: This disclosure relates to novel MECP2 targeting sequences. Novel MECP2 targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
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公开(公告)号：US20250066780A1
公开(公告)日：2025-02-27
申请号：US18756700
申请日：2024-06-27
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Ken Yamada , Vignesh Narayan Hariharan , Julianna Buchwald
IPC: C12N15/113
Abstract: This disclosure relates to oligonucleotides with internucleotide linkage modifications and used thereof for treating and preventing kidney diseases. In particular, the present disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotide to kidney. The oligonucleotide disclosed herein can be delivered to the kidney upon administration.
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公开(公告)号：US20240425860A1
公开(公告)日：2024-12-26
申请号：US18675670
申请日：2024-05-28
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Jonathan Watts , Zachary Kennedy , Annabelle Biscans , Bruno Miguel da Cruz Godinho , Chantal Ferguson , Dimas Echeverria Moreno , Ken Yamada , Daniel O'Reilly , Kathryn Monopoli , Vignesh Narayan Hariharan , Qi Tang , Sarah Davis , Samuel Hildebrand , Socheata Ly , Minwook Shin , Pranathi Meda Krishnamurthy , Nicholas McHugh , Jacquelyn Sousa , Jillian Caiazzi , Yann Thillier , Gitali Devi
IPC: C12N15/113
Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
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公开(公告)号：US12077758B2
公开(公告)日：2024-09-03
申请号：US17333839
申请日：2021-05-28
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Jonathan Watts , Zachary Kennedy , Annabelle Biscans , Bruno Miguel da Cruz Godinho , Chantal Ferguson , Dimas Echeverria Moreno , Ken Yamada , Daniel O′Reilly , Kathryn Monopoli , Vignesh Narayan Hariharan , Qi Tang , Sarah Davis , Samuel Hildebrand , Socheata Ly , Minwook Shin , Pranathi Meda Krishnamurthy , Nicholas McHugh , Jacquelyn Sousa , Jillian Caiazzi , Yann Thillier , Gitali Devi
IPC: C12N15/11 , C12N15/113
CPC classification number: C12N15/1131 , C12N15/1136 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/351 , C12N2310/3515 , C12N2320/32
Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
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公开(公告)号：US20230078622A1
公开(公告)日：2023-03-16
申请号：US17846526
申请日：2022-06-22
Inventor： Anastasia Khvorova , Vignesh Narayan Hariharan , Sarah Davis , Annabelle Biscans , Ananth Karumanchi
IPC: C12N15/113 , A61P7/00
Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
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Patent Agency Ranking
公开(公告)号：US20250145992A1
公开(公告)日：2025-05-08
申请号：US18918355
申请日：2024-10-17
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Daniel O'Reilly , Vignesh Narayan Hariharan , Raymond Furgal , Katherine Gross
IPC: C12N15/113
Abstract: The disclosure relates to compositions, systems, and methods comprising ethylene glycol chemical modifications on oligonucleotides to modulate silencing activity and improve stability.
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公开(公告)号：US20250059539A1
公开(公告)日：2025-02-20
申请号：US18755993
申请日：2024-06-27
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Ken Yamada , Vignesh Narayan Hariharan , Julianna Buchwald
IPC: C12N15/113 , A61P13/12 , C12N15/86
Abstract: This disclosure relates to oligonucleotides with internucleotide linkage modifications and used thereof for treating and preventing diseases. Particularly, this disclosure relates to SLC5A2 targeting sequences, and methods for treating and preventing kidney diseases using same.
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公开(公告)号：US20240293555A1
公开(公告)日：2024-09-05
申请号：US18537392
申请日：2023-12-12
Applicant: UNIVERSITY OF MASSACHUSETTS , CEDAES-SINAI MEDICAL CENTER
Inventor： Anastasia Khvorova , Ken Yamada , Vignesh Narayan Hariharan , Ananth Karumanchi
IPC: A61K47/54 , C12N15/113
CPC classification number: A61K47/549 , A61K47/548 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351
Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides. The oligonucleotide is conjugated to a functional moiety comprising a carbohydrate. In certain embodiments, the carbohydrate is a glucosamine or a derivative thereof.
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9.发明公开公开(公告)号：US20240067967A1
公开(公告)日：2024-02-29
申请号：US18321971
申请日：2023-05-23
Inventor： Anastasia Khvorova , Vignesh Narayan Hariharan , Sarah Davis , Annabelle Biscans , Ananth Karumanchi
IPC: C12N15/113 , A61P9/12
CPC classification number: C12N15/113 , A61P9/12 , C12N2310/11 , C12N2310/312 , C12N2310/315 , C12N2310/321
Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
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公开(公告)号：US20230399645A1
公开(公告)日：2023-12-14
申请号：US18197948
申请日：2023-05-16
Applicant: UNIVERSITY OF MASSACHUSETTS
Inventor： Anastasia Khvorova , Daniel O'Reilly , Vignesh Narayan Hariharan , Clemens Lochmann , David Cooper
IPC: C12N15/113 , C12N15/10
CPC classification number: C12N15/113 , C12N15/102 , C12N2310/315
Abstract: This disclosure relates to novel modified oligonucleotides with increased stability and extended in vivo mRNA silencing activity.
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