公开(公告)号：US20210388348A1

公开(公告)日：2021-12-16

申请号：US17318846

申请日：2021-05-12

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Erik Joseph Sontheimer ,  Anastasia Khvorova ,  Jonathan Kenneth Watts ,  Nadia Amrani ,  Zexiang Chen ,  Matthew Hassler ,  Dimas Echeverria Moreno ,  Julia Frances Alterman ,  Scot Wolfe ,  Ken Yamada ,  Gitali Devi ,  Han Zhang

IPC: C12N15/11 ,  C12N15/90 ,  C12N9/22

Abstract: Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5′ and/or 3′ conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.

公开(公告)号：US20240173420A1

公开(公告)日：2024-05-30

申请号：US18375206

申请日：2023-09-29

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Claudio Punzo ,  Anastasia Khvorova ,  Dimas Echeverria Moreno ,  Annabelle Biscans ,  Julia F. Alterman ,  Matthew Hassler ,  Shun-Yun Cheng

IPC: A61K47/54 ,  A61K9/00

CPC classification number: A61K47/554 ,  A61K9/0048 ,  A61K47/542 ,  A61K47/543 ,  A61K47/545 ,  A61K47/548

Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific eye distribution.

公开(公告)号：US20230021431A1

公开(公告)日：2023-01-26

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O'Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/113

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20240425860A1

公开(公告)日：2024-12-26

申请号：US18675670

申请日：2024-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O'Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/113

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US12077758B2

公开(公告)日：2024-09-03

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O′Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/11 ,  C12N15/113

CPC classification number: C12N15/1131 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20240182904A1

公开(公告)日：2024-06-06

申请号：US18375235

申请日：2023-09-29

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Claudio Punzo ,  Anastasia Khvorova ,  Dimas Echeverria Moreno ,  Annabelle Biscans ,  Julia F. Alterman ,  Matthew Hassler ,  Shun-Yun Cheng ,  Jillian Caiazzi

IPC: C12N15/113 ,  A61K47/54 ,  A61P27/02 ,  C12N15/86

CPC classification number: C12N15/1137 ,  A61K47/549 ,  A61P27/02 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2750/14122 ,  C12N2750/14143

Abstract: Provided herein are oligonucleotides (e.g., siRNA) targeting S6K1. Also provided are methods of treating a disease associated with S6K1 expression.