公开(公告)号：US08372439B2

公开(公告)日：2013-02-12

申请号：US13569140

申请日：2012-08-07

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

公开(公告)号：US08357403B2

公开(公告)日：2013-01-22

申请号：US12206508

申请日：2008-09-08

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

公开(公告)号：US20130006385A1

公开(公告)日：2013-01-03

申请号：US13569116

申请日：2012-08-07

申请人： John Daniel

发明人： John Daniel

IPC分类号： A61F2/02

CPC分类号： A61K35/50 ,  A61F2/02 ,  A61J1/00 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/40 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/60 ,  A61L2300/64 ,  A61L2430/40 ,  B65D25/205 ,  B65D81/18 ,  B65D85/70

摘要： A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.

公开(公告)号：US20120294910A1

公开(公告)日：2012-11-22

申请号：US13569140

申请日：2012-08-07

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K9/00 ,  A61K35/12

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

公开(公告)号：US20100023049A1

公开(公告)日：2010-01-28

申请号：US12572769

申请日：2009-10-02

申请人： John Daniel ,  Brian J. Lowe ,  Robert Cassell ,  Bradley F. Slaker ,  John E. Arnold, JR. ,  Thomas E. Broome

发明人： John Daniel ,  Brian J. Lowe ,  Robert Cassell ,  Bradley F. Slaker ,  John E. Arnold, JR. ,  Thomas E. Broome

IPC分类号： A61F2/01

CPC分类号： A61F2/013 ,  A61F2/01 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2250/0023 ,  A61F2250/0098

摘要： A filter disposed at the distal end of an elongate guidewire. Catheters are provided for delivering the filter to, and retrieving the filter from, a treatment site. The catheters can be over-the-wire or single operator exchange. The catheters include a housing for receiving the filter therein. The housing has an atraumatic distal end.

摘要翻译： 设置在细长导丝的远端的过滤器。 提供导管用于将过滤器输送到治疗部位并从治疗部位检索过滤器。 导管可以是线上或单个操作者交换。 导管包括用于在其中接收过滤器的壳体。 房屋有一个无创的远端。

公开(公告)号：US06249921B1

公开(公告)日：2001-06-26

申请号：US09487577

申请日：2000-01-19

申请人： John Daniel ,  Todd C. Loschelder

发明人： John Daniel ,  Todd C. Loschelder

IPC分类号： A47K320

CPC分类号： E03D9/08 ,  B05B7/0425

摘要： A bidet spout assembly includes a nozzle which has a body and a projecting conduit which functions to connect the nozzle to a water supply. The nozzle body has an interior water passage and the upper end of the nozzle body terminates in a generally planar seal seating surface. The nozzle body has an exterior wall with a threaded area thereon. A removable decorative outer cover is positioned about the nozzle body and has an interior wall with a threaded area thereon positioned for cooperation with the nozzle outer wall threaded area to removably secure the cover on the nozzle. A seal is positioned on the nozzle seal seating surface and is held in position by an aerator positioned on the seal. The aerator is held in position by the portion of the cover interior wall.

摘要翻译： 坐浴盆出口组件包括具有主体和突出导管的喷嘴，其用于将喷嘴连接到供水。 喷嘴体具有内部水通道，并且喷嘴体的上端终止于大致平面的密封座表面。 喷嘴体具有其上具有螺纹区域的外壁。 可拆卸的装饰外盖围绕喷嘴本体定位，并且具有内壁，其上具有螺纹区域，其定位成与喷嘴外壁螺纹区域配合以可拆卸地将盖固定在喷嘴上。 密封件定位在喷嘴密封座表面上并且通过位于密封件上的曝气器保持就位。 曝气器由盖内壁的一部分保持在适当位置。

公开(公告)号：US10350049B2

公开(公告)日：2019-07-16

申请号：US13984843

申请日：2012-02-13

申请人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel ,  Robert Tofe

发明人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel ,  Robert Tofe

IPC分类号： A61L27/36 ,  A61L27/50 ,  A61F2/02

摘要： Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.

公开(公告)号：US20140343688A1

公开(公告)日：2014-11-20

申请号：US13984843

申请日：2012-02-13

申请人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel ,  Robert Tofe

发明人： Brenda S. Morse ,  Somaly Sith ,  Randall Spencer ,  John Daniel ,  Robert Tofe

IPC分类号： A61F2/02 ,  A61L27/50 ,  A61L27/36

CPC分类号： A61L27/3604 ,  A61K35/50 ,  A61L27/3683 ,  A61L27/50 ,  A61L2430/40

摘要： Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.

摘要翻译： 本文描述了衍生自具有改善的物理和生物学特性的胎盘的组织移植物。 在一个方面，组织移植物包括第一膜，其包含层叠有羊膜，绒毛膜或其组合的沃顿顿胶。 Wharton果冻在移植物中的存在增强了同种异体移植羊水来源的，caderivic同种异体移植物，异种移植物或异种移植物软组织替代物的表现。

公开(公告)号：US08642092B2

公开(公告)日：2014-02-04

申请号：US13861305

申请日：2013-04-11

申请人： John Daniel ,  Randall Spencer ,  John Russo ,  Robert Tofe

发明人： John Daniel ,  Randall Spencer ,  John Russo ,  Robert Tofe

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

公开(公告)号：US08409626B2

公开(公告)日：2013-04-02

申请号：US13569134

申请日：2012-08-07

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。