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    Neuropilin/growth factor complexes and uses thereof
    11.
    发明授权
    Neuropilin/growth factor complexes and uses thereof 失效
    神经蛋白/生长因子复合物及其用途

    公开(公告)号：US06515105B1

    公开(公告)日：2003-02-04

    申请号：US09421365

    申请日：1999-10-19

    申请人： Kari Alitalo ,  Ulf Eriksson ,  Birgitta Olofsson ,  Taija Makinen

    发明人： Kari Alitalo ,  Ulf Eriksson ,  Birgitta Olofsson ,  Taija Makinen

    IPC分类号： C07K100

    CPC分类号： C07K14/71 ,  C07K14/52 ,  C07K2319/00

    摘要： Complexes of a protein selected from the group consisting of VEGF-B167, VEGF-C, VEGF-D and processed VEGF-B186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B167, VEGF-C, VEGF-D or processed VEGF-B186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B167, VEGF-C, VEGF-D and/or processed VEGF-B186; and specific binding partners, e.g. antibodies, for such complexes.

    摘要翻译： 选自VEGF-B167，VEGF-C，VEGF-D和加工的VEGF-B186及其类似物的蛋白质与神经蛋白-1（NP-1）受体，细胞外结构域或配体结合片段的复合物 或其类似物; 对于对VEGF-B167，VEGF-C，VEGF-D或加工的VEGF-B186具有基本上与细胞表面受体具有相同结合亲和力的生长因子蛋白和/或促进或拮抗细胞应答介导的生长因子蛋白 通过VEGF-B167，VEGF-C，VEGF-D和/或加工的VEGF-B186; 和特异性结合配偶体，例如 抗体。

    Isolated proteins having retinol dehydrogenase activity, and which associate with retinol binding receptors
    12.
    发明授权
    Isolated proteins having retinol dehydrogenase activity, and which associate with retinol binding receptors 失效
    分离的蛋白质具有视黄醇脱氢酶活性，并与视黄醇结合受体相关

    公开(公告)号：US06399344B1

    公开(公告)日：2002-06-04

    申请号：US08937993

    申请日：1997-09-26

    申请人： Ulf Eriksson ,  Andras Simon ,  Anna Romert

    发明人： Ulf Eriksson ,  Andras Simon ,  Anna Romert

    IPC分类号： C12N904

    CPC分类号： C12N9/0006

    摘要： Isolated membrane associated proteins which have a molecular weight of from about 30 kD to about 36 kilodaltons as determined by SDS-PAGE, are disclosed. The proteins have cis retinol dehydrogenase activity, such as 9, 11 or 13 cis retinol dehydrogenase activity, or cis activity at more than one position. Other trans-retinol dehydrogenases are also disclosed. Nucleic acid molecules which code for the proteins are also disclosed.

    摘要翻译： 公开了通过SDS-PAGE测定的具有约30kD至约36千道尔顿的分离膜相关蛋白。 蛋白质具有顺式视黄醇脱氢酶活性，例如9,11或13顺式视黄醇脱氢酶活性，或多于一个位置的顺式活性。 还公开了其他反式视黄醇脱氢酶。 还公开了编码蛋白质的核酸分子。

    Isolated nucleic acid molecule which codes for a 32 KDA protein having 11-CIS retinol dehydrogenase activity, and which associates with P63, a portion of a retinol binding protein receptor
    13.
    发明授权
    Isolated nucleic acid molecule which codes for a 32 KDA protein having 11-CIS retinol dehydrogenase activity, and which associates with P63, a portion of a retinol binding protein receptor 失效
    编码具有11-CIS视黄醇脱氢酶活性的32KDA蛋白的分离的核酸分子，其与P63相结合，视黄醇结合蛋白受体的一部分

    公开(公告)号：US06280997B1

    公开(公告)日：2001-08-28

    申请号：US08729594

    申请日：1996-10-11

    申请人： Ulf Eriksson ,  Andras Simon ,  Anna Romert

    发明人： Ulf Eriksson ,  Andras Simon ,  Anna Romert

    IPC分类号： C12N1512

    CPC分类号： C12N9/0006

    摘要： In accordance with this invention, an RPE cell membrane associated protein which has a molecular weight of about 32 kd, as determined by SDS-PAGE, has been discovered. This protein, referred to an “p32,” forms an oligomeric protein complex with the previously characterized p63 protein, a component of the membrane receptor for RBP. A nucleic acid molecule which codes for the p32 protein has also been isolated and sequence analysis shows that the p32 protein belongs to the family of short chain alcohol dehydrogenases, and exhibits 11-cis retinol dehydrogenase activity, the enzyme which catalyzes conversion of 11-cis-retinol into 11-cis retinaldehyde.

    摘要翻译： 根据本发明，已经发现通过SDS-PAGE测定的具有约32kd分子量的RPE细胞膜相关蛋白。 这种称为“p32”的蛋白质与先前表征的p63蛋白形成寡聚蛋白复合物，后者是RBP膜受体的一个成分。 编码p32蛋白的核酸分子也已经被分离，序列分析显示p32蛋白属于短链醇脱氢酶家族，并且表现出11-顺式视黄醇脱氢酶活性，该酶催化11-顺式 - 维甲酸变为11-顺式视黄醛。

    TREATMENT OF TYPE 2 DIABETES AND RELATED CONDITIONS
    15.
    发明申请
    TREATMENT OF TYPE 2 DIABETES AND RELATED CONDITIONS 审中-公开
    治疗2型糖尿病及相关情况

    公开(公告)号：US20150246117A1

    公开(公告)日：2015-09-03

    申请号：US14430263

    申请日：2013-09-24

    申请人： Ulf ERIKSSON

    发明人： Ulf Eriksson

    IPC分类号： A61K39/395 ,  A61K45/06

    CPC分类号： A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/76 ,  A61K2300/00

    摘要： The present disclosure provides methods of treating diabetic conditions, restoring insulin sensitivity and/or improving regulation of glycemia using an antagonist of VEGF-B, particularly in combination with other anti-diabetic agents such as insulin secretagogues. Compositions are also provided comprising one or more VEGF-B antagonists, particularly in combination with other anti-diabetic agents such as insulin secretagogues. In particular embodiments, the VEGF-B antagonist is an anti-VEGF-B antibody. In further particular embodiments, the other anti-diabetic agent or insulin secretagogue is a DPP-4 inhibitor or a GLP-1R agonist.

    摘要翻译： 本公开提供了使用VEGF-B的拮抗剂，特别是与其它抗糖尿病药如胰岛素促分泌素组合治疗糖尿病状况，恢复胰岛素敏感性和/或改善血糖调节的方法。 还提供了包含一种或多种VEGF-B拮抗剂的组合物，特别是与其它抗糖尿病药如胰岛素促分泌素组合。 在具体实施方案中，VEGF-B拮抗剂是抗VEGF-B抗体。 在另外的具体实施方案中，其它抗糖尿病剂或胰岛素促分泌素是DPP-4抑制剂或GLP-1R激动剂。

    Methods and Compositions for PDGF-C Activation and Inhibition
    19.
    发明申请
    Methods and Compositions for PDGF-C Activation and Inhibition 审中-公开
    PDGF-C激活和抑制的方法和组合

    公开(公告)号：US20100221254A1

    公开(公告)日：2010-09-02

    申请号：US12652998

    申请日：2010-01-06

    申请人： Linda Fredriksson ,  Hong Li ,  Christina Fieber ,  Xuri Li ,  Ulf Eriksson

    发明人： Linda Fredriksson ,  Hong Li ,  Christina Fieber ,  Xuri Li ,  Ulf Eriksson

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P35/00 ,  A61P9/10

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K14/49 ,  C07K14/8132 ,  C07K16/40 ,  C12N9/6459 ,  C12N9/99 ,  C12Y304/21069

    摘要： Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.

    摘要翻译： 抑制血管发生的方法包括施用组织纤溶酶原激活剂（tPA）抑制剂和适用于包含tPA抑制剂的方法的药物组合物。 还提供了用于刺激血管生成的方法，其包括向有需要的患者施用tPA，以及包含用于刺激方法的有效量的tPA的药物组合物。 本发明公开了tPA是特异性PDGF-C活化蛋白酶，PDGF-CC中的CUB结构域与蛋白酶直接相互作用，是有效的蛋白水解所必需的，而释放的CUB结构域是tPA抑制剂。 优选地，本发明的方法和组合物用于同时刺激或同时抑制溶栓和血管发生。

    Steering Wheel Adjusting Mechanism for Motor Vehicles
    20.
    发明申请
    Steering Wheel Adjusting Mechanism for Motor Vehicles 有权
    机动车辆方向盘调整机构

    公开(公告)号：US20080111362A1

    公开(公告)日：2008-05-15

    申请号：US11793758

    申请日：2005-12-16

    申请人： Ulf Eriksson

    发明人： Ulf Eriksson

    IPC分类号： B62D1/18

    CPC分类号： B62D1/184

    摘要： The invention relates to a steering wheel adjusting mechanism (2) for motor vehicles (4) comprising a pivotally to the vehicle (4) attached supporting arm (8), and a pivotally to the supporting arm (8) attached steering shaft housing unit (12), where at least one locking plate package (14 and 16, respectively) is attached to both the vehicle (4) and the steering shaft housing unit (12), which locking plate package (14 and 16, respectively) is compressible with clamping means (18) in order to lock the steering shaft housing unit (12) relative to the vehicle (4). Optionally, the supporting arm (8) is pivotally attached to a to the vehicle (4) mountable fastening part (20). Optionally, the locking plate package (14 and 16, respectively) is attached to a firmly to the vehicle (4) mountable fastening unit (22). Optionally, the fastening part (20) and the fastening unit (22) are integrated with each other to a firmly to the vehicle (4) mountable steering wheel adjusting bracket (24).

    摘要翻译： 本发明涉及一种用于机动车辆（4）的方向盘调节机构（2），其包括枢转地连接到车辆（4）附接的支撑臂（8），并且枢转地连接到支撑臂（8），转向轴壳体单元 12），其中至少一个锁定板封装（分别为14和16）分别连接到车辆（4）和转向轴壳体单元（12）上，该锁定板封装（14和16）分别可压缩 夹紧装置（18），以便相对于车辆（4）锁定转向轴壳体单元（12）。 可选地，支撑臂（8）可枢转地附接到车辆（4）可安装紧固部分（20）。 可选地，锁定板封装（14和16分别）被牢固地附接到车辆（4）可安装紧固单元（22）。 可选地，紧固部件（20）和紧固单元（22）彼此一体地牢固地固定到车辆（4）可安装的方向盘调节支架（24）上。