公开(公告)号：US5801173A

公开(公告)日：1998-09-01

申请号：US687840

申请日：1996-07-26

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07D417/14 ,  C07D417/12 ,  A61K31/425

CPC分类号： C07D417/14

摘要： Novel antidiabetic compounds, their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceuticaly acceptable compositions containing them; methods for preparing the antidiabetic compounds and their uses.

摘要翻译： 新型抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物; 制备抗糖尿病化合物的方法及其用途。

公开(公告)号：US6159966A

公开(公告)日：2000-12-12

申请号：US134348

申请日：1998-08-14

申请人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Chennaveerappa Bajji ,  Shivaramayya Kalchar ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Reeba Kannimel Vikramadithyan

发明人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Chennaveerappa Bajji ,  Shivaramayya Kalchar ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Reeba Kannimel Vikramadithyan

IPC分类号： C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  A61K31/535 ,  A61K31/54 ,  C07D265/36 ,  C07D279/16

CPC分类号： C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are the same or different; R.sup.1 and R.sup.2 together represent along with carbon atoms to which they are attached an aromatic cyclic structure containing 5-6 ring atoms which may optionally be substituted; X represents a heteroatom selected from oxygen or sulfur; R.sup.7 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl group or forms a bond together with R.sup.8 ; R.sup.8 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl or R.sup.8 forms a bond together with R.sup.7 ; B represents an oxygen atom or a sulfur atom; Y represents an oxygen atom or a sulfur atom, n is an integer ranging from 1 to 4 and m is an integer of zero or one, compositions containing compounds of formula (I) and methods of use of the compounds are described.

摘要翻译： 式（I）化合物其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐或其药学上可接受的溶剂合物，其中R 3，R 4，R 5和R 6相同或不同; R1和R2一起表示与它们所连接的碳原子一起含有5-6个可以被取代的环原子的芳环结构; X表示选自氧或硫的杂原子; R 7表示氢原子，羟基，烷氧基，卤素，低级烷基或任意取代的芳烷基，或与R 8一起形成键; R8代表氢原子，羟基，烷氧基，卤素，低级烷基或任选取代的芳烷基或R8与R7一起形成一个键; B表示氧原子或硫原子; Y表示氧原子或硫原子，n表示1〜4的整数，m表示0以下的整数，或者1表示含有式（I）的化合物的组合物和使用该化合物的方法。

公开(公告)号：US6011031A

公开(公告)日：2000-01-04

申请号：US982910

申请日：1997-12-02

申请人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Chennaveerappa Bajji ,  Shivaramayya Kalchar ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Reeba Kannimel Vikramadithyan

发明人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Chennaveerappa Bajji ,  Shivaramayya Kalchar ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Reeba Kannimel Vikramadithyan

IPC分类号： C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  A61K31/535 ,  A61K31/54 ,  C07D265/36 ,  C07D279/16

CPC分类号： C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them; methods for preparing the antidiabetic compounds and their uses.

摘要翻译： 新型抗糖尿病化合物，其互变异构形式，其衍生物，其类似物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物; 制备抗糖尿病化合物的方法及其用途。

公开(公告)号：US6130214A

公开(公告)日：2000-10-10

申请号：US179141

申请日：1998-10-26

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07C235/48 ,  C07C323/62 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08 ,  A61K31/54 ,  A61K31/535 ,  C07D265/12 ,  C07D279/16

CPC分类号： C07C323/62 ,  C07C235/48 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel .beta.-aryl-.alpha.-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. ##STR1##

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地说，本发明涉及通式（I）的新型β-芳基-α-氧基取代的烷基羧酸，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。

公开(公告)号：USRE39266E1

公开(公告)日：2006-09-05

申请号：US10697926

申请日：2003-10-30

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K. S. Pakala

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K. S. Pakala

IPC分类号： A01K31/505 ,  C07D239/02 ,  C07D239/70

CPC分类号： C07D239/36 ,  C07D239/47 ,  C07D239/88 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

公开(公告)号：US07053217B2

公开(公告)日：2006-05-30

申请号：US10041384

申请日：2002-01-08

申请人： Ranga Madhavan Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

发明人： Ranga Madhavan Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

IPC分类号： C07D239/22

CPC分类号： C07D239/36 ,  C07C217/22 ,  C07C237/32 ,  C07C247/04 ,  C07D239/90

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，它们的类似物，其互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂化物和含有它们的药物组合物的方法。 本发明还涉及新型中间体，其制备方法及其在制备式（I）化合物中的用途。

公开(公告)号：US06313113B1

公开(公告)日：2001-11-06

申请号：US08982911

申请日：1997-12-02

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： A61K31536

CPC分类号： C07D417/12 ,  C07D265/22 ,  C07D277/20 ,  C07D277/34 ,  C07D413/12

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinediones of the general formula (I), their analogues, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them

摘要翻译： 本发明涉及新型抗糖尿病化合物，其互变异构形式，其衍生物，其类似物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新型唑烷二酮类，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物

公开(公告)号：US6011036A

公开(公告)日：2000-01-04

申请号：US982962

申请日：1997-12-02

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07D265/22 ,  C07D277/20 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  A61K31/50 ,  A61K31/535 ,  C07D237/30 ,  C07D265/02

CPC分类号： C07D417/12 ,  C07D265/22 ,  C07D277/20 ,  C07D277/34 ,  C07D413/12

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their analogues, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione compounds of the general formula (I), and their analogues, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##

摘要翻译： 本发明涉及新型抗糖尿病化合物，其互变异构形式，其类似物，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑烷二酮化合物及其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂化物和含有它们的药物组合物。

公开(公告)号：US06780992B2

公开(公告)日：2004-08-24

申请号：US10032846

申请日：2001-12-26

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K.S. Pakala

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K.S. Pakala

IPC分类号： C07D23510

CPC分类号： C07D239/36 ,  C07D239/47 ,  C07D239/88 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及新的抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑来二酮衍生物及其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。

公开(公告)号：US06310069B1

公开(公告)日：2001-10-30

申请号：US09535387

申请日：2000-03-24

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K. S. Pakala

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K. S. Pakala

IPC分类号： A01K31505

CPC分类号： C07D239/36 ,  C07D239/47 ,  C07D239/88 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及新的抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑来二酮衍生物及其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。