公开(公告)号：US09333080B2

公开(公告)日：2016-05-10

申请号：US13972640

申请日：2013-08-21

申请人： WARSAW ORTHOPEDIC, INC.

发明人： Deger C. Tunc ,  John Winterbottom ,  David R. Kaes ,  Todd M. Boyce ,  David Knaack ,  James Russell ,  Subhabrata Bhattacharyya

IPC分类号： A61K9/00 ,  A61F2/28 ,  A61L27/44 ,  A61L27/46 ,  A61F2/30

CPC分类号： A61F2/28 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61F2310/00365 ,  A61L27/446 ,  A61L27/46 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/06 ,  A61L2400/08 ,  A61L2430/02

摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.

公开(公告)号：US20200275963A1

公开(公告)日：2020-09-03

申请号：US16879347

申请日：2020-05-20

申请人： Warsaw Orthopedic, Inc.

发明人： Kelly W. Schlachter ,  Daniel A. Shimko ,  Kerem N. Kalpakci ,  Erick Vasquez ,  David R. Kaes ,  Subhabrata Bhattacharyya

IPC分类号： A61B17/88 ,  A61F2/46 ,  A61F2/28 ,  A61F2/30 ,  A61L27/36 ,  A61L27/54 ,  B01F13/00 ,  B01F13/06 ,  B01F15/00 ,  B01F15/02

摘要： A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.

公开(公告)号：US20190336191A1

公开(公告)日：2019-11-07

申请号：US16515905

申请日：2019-07-18

申请人： Warsaw Orthopedic, Inc.

发明人： Kelly W. Schlachter ,  Daniel A. Shimko ,  Kerem Kalpakci ,  Erick Vasquez ,  David R. Kaes ,  Subhabrata Bhattacharyya

IPC分类号： A61B17/88 ,  A61L27/54 ,  A61L27/36 ,  A61F2/46 ,  A61F2/30 ,  A61F2/28 ,  B01F13/00 ,  B01F13/06 ,  B01F15/00 ,  B01F15/02

摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

公开(公告)号：US10194964B2

公开(公告)日：2019-02-05

申请号：US14941073

申请日：2015-11-13

申请人： Warsaw Orthopedic, Inc.

发明人： Kelly W. Schlachter ,  Daniel A. Shimko ,  Kerem N. Kalpakci ,  Erick Vasquez ,  David R. Kaes ,  Subhabrata Bhattacharyya

IPC分类号： A61F2/46 ,  A61B17/88 ,  A61F2/28 ,  A61F2/30 ,  A61L27/36 ,  A61L27/54 ,  B01F13/00 ,  B01F13/06 ,  B01F15/00 ,  B01F15/02

摘要： A bone material comprising a coherent mass of cartridge milled and demineralized bone fibers is provided, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material comprising a lyophilized coherent mass of cartridge milled and demineralized bone fibers is provided, the lyophilized coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a method of making an implantable bone material is provided, the method comprising drying a coherent mass of cartridge milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass.

公开(公告)号：US20180193077A1

公开(公告)日：2018-07-12

申请号：US15912038

申请日：2018-03-05

申请人： Warsaw Orthopedic, Inc.

发明人： Kelly W. Schlachter ,  Daniel A. Shimko ,  Kerem Kalpakci ,  Erick Vasquez ,  David R. Kaes ,  Subhabrata Bhattacharyya

IPC分类号： A61B17/88 ,  B01F15/02 ,  B01F13/06 ,  B01F13/00 ,  B01F15/00 ,  A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61L27/36 ,  A61L27/54

CPC分类号： A61B17/8816 ,  A61B17/8805 ,  A61B2017/8838 ,  A61F2/28 ,  A61F2/30942 ,  A61F2/4601 ,  A61F2/4644 ,  A61F2002/2835 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/02 ,  B01F13/0023 ,  B01F13/06 ,  B01F15/00506 ,  B01F15/0278

摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

公开(公告)号：US09913676B2

公开(公告)日：2018-03-13

申请号：US14941033

申请日：2015-11-13

申请人： Warsaw Orthopedic, Inc.

发明人： Kelly W. Schlachter ,  Daniel A. Shimko ,  Kerem N. Kalpakci ,  Erick Vasquez ,  David R. Kaes ,  Subhabrata Bhattacharyya

IPC分类号： A61F2/28 ,  A61B17/88 ,  A61F2/30 ,  A61L27/36 ,  A61L27/54 ,  B01F13/00 ,  B01F13/06 ,  B01F15/00 ,  B01F15/02 ,  A61F2/46

CPC分类号： A61B17/8816 ,  A61B17/8805 ,  A61B2017/8838 ,  A61F2/28 ,  A61F2/30942 ,  A61F2/4601 ,  A61F2/4644 ,  A61F2002/2835 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/02 ,  B01F13/0023 ,  B01F13/06 ,  B01F15/00506 ,  B01F15/0278

摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

公开(公告)号：US20180044638A1

公开(公告)日：2018-02-15

申请号：US15232275

申请日：2016-08-09

申请人： Warsaw Orthopedic, Inc.

发明人： Subhabrata Bhattacharyya ,  David R. Kaes ,  Daniel A. Shimko

IPC分类号： C12N5/077 ,  A61F2/46 ,  C12M1/36 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42

CPC分类号： C12N5/0654 ,  A61F2/4644 ,  A61F2250/0067

摘要： A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.

公开(公告)号：US10913930B2

公开(公告)日：2021-02-09

申请号：US15232275

申请日：2016-08-09

申请人： Warsaw Orthopedic, Inc.

发明人： Subhabrata Bhattacharyya ,  David R. Kaes ,  Daniel A. Shimko

IPC分类号： C12N5/077 ,  A61F2/46 ,  G01N1/31 ,  A61L27/54

摘要： A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.

公开(公告)号：US10368930B2

公开(公告)日：2019-08-06

申请号：US15912038

申请日：2018-03-05

申请人： Warsaw Orthopedic, Inc.

发明人： Kelly W. Schlachter ,  Daniel A. Shimko ,  Kerem Kalpakci ,  Erick Vasquez ,  David R. Kaes ,  Subhabrata Bhattacharyya

IPC分类号： A61B17/88 ,  A61F2/28 ,  A61F2/30 ,  A61L27/36 ,  A61L27/54 ,  B01F13/00 ,  B01F13/06 ,  B01F15/00 ,  B01F15/02 ,  A61F2/46

摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

公开(公告)号：US10006705B2

公开(公告)日：2018-06-26

申请号：US14617170

申请日：2015-02-09

申请人： Warsaw Orthopedic, Inc.

发明人： Guobao Wei ,  David R. Kaes ,  Susan J. Drapeau ,  Subhabrata Bhattacharyya

IPC分类号： F26B5/04 ,  A21C9/08

CPC分类号： F26B5/04 ,  A21C9/083

摘要： Methods for treating bulk bone tissue are provided. The methods comprise contacting bulk bone tissue or frozen bulk bone tissue with an effective amount of a supercritical fluid so as to dry the bulk bone tissue. In various embodiments, the supercritical fluid destroys contaminants such that the frozen bulk bone tissue is 99.9% substantially pure. In various embodiments, contaminants removed from the frozen bulk bone tissue include lipids, viruses, bacteria, pyrogens, prions, micro-organisms and/or pathogens. In some embodiments, the supercritical fluid causes a 3 log reduction of bacteria within the frozen bulk bone tissue.