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公开(公告)号：US20120150087A1
公开(公告)日：2012-06-14
申请号：US13364837
申请日：2012-02-02
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61F13/02 , A61K9/00 , A61K39/395 , A61P7/04 , A61K39/00 , A61K9/127 , A61P17/02 , A61K38/48 , A61K38/19
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin, wherein the thrombin is present in an amount between 0.250 Units/mg of fibrinogen component and 0.062 Units/mg of fibrinogen component. Also disclosed are methods for treating wounded tissue.
摘要翻译： 公开了哺乳动物患者（例如人）中治疗的受伤组织的固体敷料，其包含基本上由纤维蛋白原成分和凝血酶组成的止血层，其中凝血酶以0.250单位/ mg纤维蛋白原成分和0.062单位/ mg纤维蛋白原成分。 还公开了治疗伤口组织的方法。
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公开(公告)号：US20080033332A1
公开(公告)日：2008-02-07
申请号：US11882876
申请日：2007-08-06
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61F13/00
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator, wherein the fibrinogen is present in an amount between 3.0 mg/cm2 of the wound facing surface of the dressing and 13.0 mg/cm2 of the wound facing surface of the dressing. Also disclosed are methods for treating wounded tissue.
摘要翻译： 公开了用于哺乳动物患者例如人的治疗伤口组织的固体敷料，其包含基本上由纤维蛋白原和纤维蛋白原激活剂组成的止血层，其中纤维蛋白原以3.0mg / cm 2 / >敷料的面向伤口的表面和敷料的面向伤口表面的13.0mg / cm 2。 还公开了治疗伤口组织的方法。
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公开(公告)号：US20120321692A1
公开(公告)日：2012-12-20
申请号：US13302019
申请日：2012-02-07
申请人： Martin MacPhee , Jerry Kanellos , Belinda Wilmer , Dawson Beall
发明人： Martin MacPhee , Jerry Kanellos , Belinda Wilmer , Dawson Beall
IPC分类号： A61K38/36 , A61K9/127 , A61K38/19 , A61K39/395 , A61K38/48 , A61K38/18 , A61K38/22 , A61P31/00 , A61P7/02 , A61P9/00 , A61P35/00 , A61P31/12 , A61P31/10 , A61P33/00 , A61P29/00 , A61P3/02 , A61P17/02 , A61B17/03 , A61K9/70
CPC分类号： A61L15/64 , A61B17/00491 , A61B17/0057 , A61B2017/0065 , A61F2013/00472 , A61K38/363 , A61K38/4833 , A61L15/28 , A61L15/32 , A61L15/44 , A61L26/0042 , A61L26/009 , A61L2300/23 , A61L2300/252 , A61L2300/254 , A61L2400/04 , C12Y304/21005
摘要： Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings.
摘要翻译： 披露了基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的固体和冷冻止血材料和敷料。 还公开了通过应用这些止血材料和敷料中的一种或多种来治疗哺乳动物的内部受伤组织的方法。
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公开(公告)号：US20110196421A1
公开(公告)日：2011-08-11
申请号：US13080086
申请日：2011-04-05
申请人： Martin MacPhee , Jerry Kanellos , Belinda Wilmer , Dawson Beall
发明人： Martin MacPhee , Jerry Kanellos , Belinda Wilmer , Dawson Beall
IPC分类号： A61B17/03
CPC分类号： A61L15/64 , A61B17/00491 , A61B17/0057 , A61B2017/0065 , A61F2013/00472 , A61K38/363 , A61K38/4833 , A61L15/28 , A61L15/32 , A61L15/44 , A61L26/0042 , A61L26/009 , A61L2300/23 , A61L2300/252 , A61L2300/254 , A61L2400/04 , C12Y304/21005
摘要： Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings.
摘要翻译： 披露了基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的固体和冷冻止血材料和敷料。 还公开了通过应用这些止血材料和敷料中的一种或多种来治疗哺乳动物的内部受伤组织的方法。
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公开(公告)号：US20080033331A1
公开(公告)日：2008-02-07
申请号：US11882874
申请日：2007-08-06
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.
摘要翻译： 公开了用于哺乳动物患者例如人的治疗伤口组织的固体敷料，其包含基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的止血层，其中止血层由含有 纤维蛋白原组分和纤维蛋白原激活剂。 还公开了使用这些敷料和用于制备这些敷料的止血层的冷冻组合物来治疗伤口组织的方法。
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公开(公告)号：US20130287837A1
公开(公告)日：2013-10-31
申请号：US13843604
申请日：2013-03-15
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61L26/00
CPC分类号： A61L15/44 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0206 , A61F13/0223 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00927 , A61F2013/00931 , A61L15/225 , A61L15/32 , A61L15/38 , A61L15/64 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L2300/418 , A61L2400/04 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.
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17.发明授权公开(公告)号：US08445009B2
公开(公告)日：2013-05-21
申请号：US11882872
申请日：2007-08-06
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are processes for preparing solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen and liquid compositions useful for preparing the haemostatic layer(s) of these dressings or for treating wounded tissue in a mammal.
摘要翻译： 公开的是在哺乳动物患者（例如人）中制备用于治疗的受伤组织的固体敷料的方法，其包含基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的止血层。 还公开了使用这些敷料处理伤口组织的方法以及用于制备这些敷料的止血层或用于治疗哺乳动物中伤口组织的冷冻和液体组合物。
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公开(公告)号：US20120148658A1
公开(公告)日：2012-06-14
申请号：US13363489
申请日：2012-02-01
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61L15/44 , A61K38/18 , A61K39/395 , A61K38/22 , A61F13/02 , A61K9/127 , A61K38/48 , A61K35/58 , A61P17/02 , A61P7/04 , A61K38/36 , A61K39/00
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator, wherein the fibrinogen is present in an amount between 3.0 mg/cm2 of the wound facing surface of the dressing and 13.0 mg/cm2 of the wound facing surface of the dressing. Also disclosed are methods for treating wounded tissue.
摘要翻译： 公开了用于哺乳动物患者（例如人）中治疗的受伤组织的固体敷料，其包含基本上由纤维蛋白原和纤维蛋白原激活剂组成的止血层，其中纤维蛋白原的存在量为3.0mg / 敷料和敷料的面向伤口面积的13.0 mg / cm2。 还公开了治疗伤口组织的方法。
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公开(公告)号：US20080033333A1
公开(公告)日：2008-02-07
申请号：US11882879
申请日：2007-08-06
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61F13/00
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin, wherein the thrombin is present in an amount between 0.250 Units/mg of fibrinogen component and 0.062 Units/mg of fibrinogen component. Also disclosed are methods for treating wounded tissue.
摘要翻译： 公开了哺乳动物患者（例如人）中治疗的受伤组织的固体敷料，其包含基本上由纤维蛋白原成分和凝血酶组成的止血层，其中凝血酶以0.250单位/ mg纤维蛋白原成分和0.062单位/ mg纤维蛋白原成分。 还公开了治疗伤口组织的方法。
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公开(公告)号：US20120148659A1
公开(公告)日：2012-06-14
申请号：US13364762
申请日：2012-02-02
申请人： Martin MacPhee , Dawson Beall
发明人： Martin MacPhee , Dawson Beall
IPC分类号： A61L15/44 , A61K38/18 , A61K39/395 , A61F13/02 , A61K9/127 , A61K38/48 , A61K35/58 , A61K38/36 , A61K38/22
CPC分类号： A61L15/64 , A61F13/00012 , A61F13/00017 , A61F13/00021 , A61F13/00029 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00991 , A61F13/02 , A61F13/0226 , A61F13/0246 , A61F2013/00106 , A61F2013/00174 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/0091 , A61F2013/00931 , A61K38/363 , A61K38/4833 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/38 , A61L15/44 , A61L15/58 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/009 , A61L2300/10 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/04 , C12Y304/21005 , C08L89/00
摘要： Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.
摘要翻译： 公开了用于哺乳动物患者例如人的治疗伤口组织的固体敷料，其包含基本上由纤维蛋白原组分和纤维蛋白原激活剂组成的止血层，其中止血层由含有 纤维蛋白原组分和纤维蛋白原激活剂。 还公开了使用这些敷料和用于制备这些敷料的止血层的冷冻组合物来治疗伤口组织的方法。
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