公开(公告)号：US07659378B2

公开(公告)日：2010-02-09

申请号：US11757094

申请日：2007-06-01

申请人： May Han ,  S. Kirk Wright ,  William M. Winston, Jr. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

发明人： May Han ,  S. Kirk Wright ,  William M. Winston, Jr. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

IPC分类号： C07K16/00 ,  C07K16/24

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

公开(公告)号：US07935502B2

公开(公告)日：2011-05-03

申请号：US12632758

申请日：2009-12-07

申请人： May Han ,  S. Kirk Wright ,  William M. Winston, Jr. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

发明人： May Han ,  S. Kirk Wright ,  William M. Winston, Jr. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

IPC分类号： C12P21/06 ,  C12N5/07 ,  C12N15/63 ,  C07H21/04

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

公开(公告)号：US20130203970A1

公开(公告)日：2013-08-08

申请号：US13589652

申请日：2012-08-20

申请人： May Han ,  S. Kirk Wright ,  William M. Winston, JR. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

发明人： May Han ,  S. Kirk Wright ,  William M. Winston, JR. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

IPC分类号： C07K16/22

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

公开(公告)号：US20100173361A1

公开(公告)日：2010-07-08

申请号：US12632758

申请日：2009-12-07

申请人： May Han ,  S. Kirk Wright ,  William M. Winston, JR. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

发明人： May Han ,  S. Kirk Wright ,  William M. Winston, JR. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

IPC分类号： C12P21/06 ,  C12N5/07 ,  C12N15/63 ,  C07H21/04

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

公开(公告)号：US20080038257A1

公开(公告)日：2008-02-14

申请号：US11757094

申请日：2007-06-01

申请人： May Han ,  S. Wright ,  William Winston ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

发明人： May Han ,  S. Wright ,  William Winston ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  C12N15/00 ,  C12N5/00 ,  C12P21/00

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。

公开(公告)号：US20100291106A1

公开(公告)日：2010-11-18

申请号：US12773246

申请日：2010-05-04

申请人： Bijan Etemad-Gilbertson ,  Braydon Charles Guild ,  Yong-In Kim ,  Ingo Klagge ,  Alexandra Kraus ,  Michael Roguska ,  Igor Splawski ,  Kehao Zhao

发明人： Bijan Etemad-Gilbertson ,  Braydon Charles Guild ,  Yong-In Kim ,  Ingo Klagge ,  Alexandra Kraus ,  Michael Roguska ,  Igor Splawski ,  Kehao Zhao

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07H21/04 ,  C12N15/63 ,  C12N5/071 ,  A61P27/02

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to antibodies and antigen binding fragments thereof that bind to both human and cynomolgus complement protein C3b, as well as compositions and methods of use thereof.

摘要翻译： 本发明涉及结合人和食蟹猴补体蛋白C3b的抗体及其抗原结合片段，以及其组合物和使用方法。