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公开(公告)号:US20070112005A1
公开(公告)日:2007-05-17
申请号:US11599663
申请日:2006-11-15
申请人: Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
发明人: Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
IPC分类号: A61K31/498 , A61K31/53 , C07D487/12
CPC分类号: C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐是mTOR的抑制剂,可用于治疗癌症。
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公开(公告)号:US20070129364A1
公开(公告)日:2007-06-07
申请号:US11634003
申请日:2006-12-05
申请人: Han-Qing Dong , Kenneth Foreman , An-Hu Li , Mark Mulvihill , Bijoy Panicker , Arno Steinig , Kathryn Stolz , Qinghua Weng , Meizhong Jin , Brian Volk , Jing Wang , Ti Wang , James Beard
发明人: Han-Qing Dong , Kenneth Foreman , An-Hu Li , Mark Mulvihill , Bijoy Panicker , Arno Steinig , Kathryn Stolz , Qinghua Weng , Meizhong Jin , Brian Volk , Jing Wang , Ti Wang , James Beard
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号: C07D471/04
摘要: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least one of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Met, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译: 由式(I)表示的化合物或其立体异构体或其药学上可接受的盐是Abl,Aurora-A,Blk,c-Raf,cSRC,Src,PRK2,FGFR3,Flt3,Lck,Mek1,PDK中的至少一种的抑制剂 -1,GSK3beta,EGFR,p70S6K,BMX,SGK,CaMKII,Tie-2,IGF-1R,Ron,Met和KDR激酶,用于治疗和/或预防各种疾病和病症, 癌症。
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公开(公告)号:US08399433B2
公开(公告)日:2013-03-19
申请号:US12791047
申请日:2010-06-01
申请人: Rama Devi Appari , Xin Chen , Ramesh Chilukuri , Andrew P. Crew , Hanqing Dong , Caterina Ferraro , Kenneth Foreman , Ramesh C. Gupta , An-Hu Li , Dan Sherman , Kathryn M. Stolz , Brian Volk , Robert Zahler
发明人: Rama Devi Appari , Xin Chen , Ramesh Chilukuri , Andrew P. Crew , Hanqing Dong , Caterina Ferraro , Kenneth Foreman , Ramesh C. Gupta , An-Hu Li , Dan Sherman , Kathryn M. Stolz , Brian Volk , Robert Zahler
IPC分类号: A61K31/675 , C07D279/10 , C07D413/12 , C07F9/08
CPC分类号: C07F9/65583 , A61K31/497 , C07D401/12 , C07D403/12 , C07D403/14 , C07F9/6512 , C07F9/6544
摘要: Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.
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公开(公告)号:US20050154256A1
公开(公告)日:2005-07-14
申请号:US10905653
申请日:2005-01-14
申请人: Robert Breidenthal , Richard Cyr , Christopher David , Joseph Forkey , Richard Forkey , Robert Ross , Brian Volk
发明人: Robert Breidenthal , Richard Cyr , Christopher David , Joseph Forkey , Richard Forkey , Robert Ross , Brian Volk
CPC分类号: G02B25/001 , A61B1/00188 , A61B1/00193 , A61B1/00195 , G02B23/2415
摘要: A convergence prism assembly with a housing and a prism structure having a plurality of prisms mounted in a unitary assembly.
摘要翻译: 具有壳体和棱镜结构的会聚棱镜组件,其具有安装在整体组件中的多个棱镜。
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公开(公告)号:US20070008628A1
公开(公告)日:2007-01-11
申请号:US11160721
申请日:2005-07-06
申请人: Brian Volk
发明人: Brian Volk
IPC分类号: G02B9/62
CPC分类号: G02B25/001 , G02B9/60
摘要: An optical device with five air-spaced optical elements. An optical device in the form of an eyepiece is disclosed with a center negative lens and two outer positive lenses on each side of the intermediate negative lens. The eyepiece transmits light from an object to an exit pupil along angles corresponding to the position of a focus point on an object. In a preferred embodiment the positive lenses are identical.
摘要翻译: 具有五个空气间隔光学元件的光学装置。 公开了一种目镜形式的光学装置,其中央负透镜和中间负透镜两侧的两个外正透镜。 目镜将光从物体传送到出射光瞳,其角度与对象上焦点的位置相对应。 在优选实施例中,正透镜是相同的。
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