摘要:
The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4′-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3′-position of their B aryl ring. Similarly, 3′-amino combretastatin is 4′-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.
摘要:
A system, method and computer program product for monitoring including detecting internal faults especially inter-turn faults of a synchronous generator and thus protecting the synchronous generator. The synchronous generator includes a winding for each phase of a power network, a terminal for each phase arranged on a terminal side of the synchronous generator, and connected to the respective winding, the terminals on the terminal side are connected to an electrical power network, and the synchronous generator is arranged to input power to the electrical power network by means of the terminals.
摘要:
Methods of increasing the resistance of plants, in particular soybeans, to nematodes, in particular soybean cyst nematodes, are provided herein. The methods include increasing the expression of Glyma18g02580, Glyma18g02590 and/or Glyma18g2610 in cells of a plant and in particular in root cells of a plant to increase the resistance of the plant and plant cells to nematodes. The methods include increasing the expression using constitutive promoters or by increasing the copy number of the polynucleotides. Constructs for expressing these polypeptides, transgenic cells, transgenic plants and methods of generating the same are also provided. Methods of screening plant cells for resistance or susceptibility to nematodes are also provided.
摘要:
This specification discloses an intelligent and digitalized process level interface which is referred to herein as an Intelligent Process Interface (IPI). The input of the IPI includes both analog and digital channels and therefore the IPI can be used for substations in transition or retrofit stages with both conventional and non-conventional primary devices. The IPI acts not only as a digitalized interface, but also as an intelligent supervisory and control unit for switching functions. The architecture of the IPI is flexible and allows for the functionality to be distributed to several devices.
摘要:
Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.
摘要:
A method for detecting an internal failure in a capacitor bank connected to a power system, wherein the capacitor bank includes a plurality of capacitor units that are divided into two Y sections. Each phase in each of the Y sections defines a leg and each leg includes series and/or parallel-connected capacitor units. The internal failure may occur in one or more capacitor elements or units or involve one or more legs. The method includes measuring the phase current in one of the phases, calculating the root mean square value, denoted by RMS, of the measured phase currents, measuring the unbalanced current between the two sections, calculating the RMS value of the measured unbalanced currents, and detecting the phase angle between the measured phase current and the measured unbalanced current.
摘要:
A protection system for high voltage direct current, HVDC, transmission lines is provided. The protection system includes a direct current, DC, bus, a device configured to connect an HVDC transmission line to the bus, at least one DC circuit breaker arranged for disconnecting the transmission line from the bus upon reception of a trip signal, current and voltage sensors, an inductor arranged such that the current through the transmission line passes the inductor, and a fault detection unit. The fault detection unit is arranged for assessing, on the basis of current and/or voltage measurements, whether a fault exists on the transmission line, and sending, if a fault is detected on the transmission line, a trip signal to the circuit breaker. The additional inductance limits the rise in fault current and facilitates a selective fault detection. Further, a method of fault protection for an HVDC transmission line is provided.