PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS
    11.
    发明申请
    PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS 审中-公开
    制备和使用乙氧基化合物及其制剂

    公开(公告)号:US20090170956A1

    公开(公告)日:2009-07-02

    申请号:US12439783

    申请日:2007-05-16

    IPC分类号: A61K31/09 C07C43/23

    摘要: The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4′-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3′-position of their B aryl ring. Similarly, 3′-amino combretastatin is 4′-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.

    摘要翻译: 本发明公开了新型乙氧基考布他汀及其前药的全合成方法。 Combretastatins通过在其B芳环的4'位上被乙氧基取代化学修饰,并通过修饰其B芳环的3'-位上的羟基而转化为磷酸或其内磷酸胆碱的可溶性前药。 类似地,3'-氨基考布他汀是4'-乙氧基化学修饰的,氨基酸的另外侧链可以被引入氨基以形成氨基酰胺的可溶性前药。 所述化合物的结构如式(I)所示。 乙氧基考布他汀具有有效的微管蛋白聚合抑制活性,可用于治疗抑制肿瘤或新生血管。

    INTELLIGENT PROCESS INTERFACE AND SUBSTATION AUTOMATION SYSTEM
    14.
    发明申请
    INTELLIGENT PROCESS INTERFACE AND SUBSTATION AUTOMATION SYSTEM 有权
    智能过程接口和基站自动化系统

    公开(公告)号:US20120089262A1

    公开(公告)日:2012-04-12

    申请号:US13272902

    申请日:2011-10-13

    IPC分类号: G06F1/26

    摘要: This specification discloses an intelligent and digitalized process level interface which is referred to herein as an Intelligent Process Interface (IPI). The input of the IPI includes both analog and digital channels and therefore the IPI can be used for substations in transition or retrofit stages with both conventional and non-conventional primary devices. The IPI acts not only as a digitalized interface, but also as an intelligent supervisory and control unit for switching functions. The architecture of the IPI is flexible and allows for the functionality to be distributed to several devices.

    摘要翻译: 本说明书公开了一种智能和数字化的处理级接口,在这里被称为智能过程接口(IPI)。 IPI的输入包括模拟和数字通道,因此IPI可以用于传统和非常规主设备的转换或改造阶段的变电站。 IPI不仅作为数字化接口,而且还作为用于切换功能的智能监控单元。 IPI的架构是灵活的,并且允许将功能分发到多个设备。

    Method and arrangement for an internal failure detection in a Y-Y connected capacitor bank
    19.
    发明授权
    Method and arrangement for an internal failure detection in a Y-Y connected capacitor bank 有权
    Y-Y连接电容器组内部故障检测的方法和装置

    公开(公告)号:US08912801B2

    公开(公告)日:2014-12-16

    申请号:US13966940

    申请日:2013-08-14

    摘要: A method for detecting an internal failure in a capacitor bank connected to a power system, wherein the capacitor bank includes a plurality of capacitor units that are divided into two Y sections. Each phase in each of the Y sections defines a leg and each leg includes series and/or parallel-connected capacitor units. The internal failure may occur in one or more capacitor elements or units or involve one or more legs. The method includes measuring the phase current in one of the phases, calculating the root mean square value, denoted by RMS, of the measured phase currents, measuring the unbalanced current between the two sections, calculating the RMS value of the measured unbalanced currents, and detecting the phase angle between the measured phase current and the measured unbalanced current.

    摘要翻译: 一种用于检测连接到电力系统的电容器组中的内部故障的方法,其中所述电容器组包括被分成两个Y部分的多个电容器单元。 每个Y部分中的每个相定义一条腿,并且每条腿包括串联和/或并联连接的电容器单元。 内部故障可能发生在一个或多个电容器元件或单元中,或涉及一个或多个支脚。 该方法包括测量其中一相中的相电流,计算测得的相电流的RMS均方根值,测量两段之间的不平衡电流,计算测得的不平衡电流的RMS值,以及 检测测得的相电流和测得的不平衡电流之间的相位角。

    Fault protection of HVDC transmission lines
    20.
    发明授权
    Fault protection of HVDC transmission lines 有权
    高压直流输电线路故障保护

    公开(公告)号:US08749933B2

    公开(公告)日:2014-06-10

    申请号:US13703930

    申请日:2010-09-13

    IPC分类号: H02H3/00 H02H7/00

    摘要: A protection system for high voltage direct current, HVDC, transmission lines is provided. The protection system includes a direct current, DC, bus, a device configured to connect an HVDC transmission line to the bus, at least one DC circuit breaker arranged for disconnecting the transmission line from the bus upon reception of a trip signal, current and voltage sensors, an inductor arranged such that the current through the transmission line passes the inductor, and a fault detection unit. The fault detection unit is arranged for assessing, on the basis of current and/or voltage measurements, whether a fault exists on the transmission line, and sending, if a fault is detected on the transmission line, a trip signal to the circuit breaker. The additional inductance limits the rise in fault current and facilitates a selective fault detection. Further, a method of fault protection for an HVDC transmission line is provided.

    摘要翻译: 提供高压直流,高压直流输电线路保护系统。 保护系统包括直流DC总线,被配置为将HVDC传输线连接到总线的装置,至少一个直流断路器,用于在接收到跳闸信号,电流和电压时将传输线与总线断开 传感器,布置成使得通过传输线的电流通过电感器的电感器和故障检测单元。 该故障检测单元被设置为基于当前和/或电压测量来评估传输线路上是否存在故障,并且如果在传输线路上检测到故障则发送到断路器的跳闸信号。 附加电感限制故障电流的上升,并有助于选择性故障检测。 此外,还提供了用于HVDC传输线的故障保护方法。