公开(公告)号：US08298831B2

公开(公告)日：2012-10-30

申请号：US12466943

申请日：2009-05-15

申请人： David D. Nolte ,  Manoj Varma ,  Fred E. Regnier ,  Leilei Peng ,  Ming Zhao

发明人： David D. Nolte ,  Manoj Varma ,  Fred E. Regnier ,  Leilei Peng ,  Ming Zhao

IPC分类号： G01N21/76

CPC分类号： G01N33/54373 ,  G01N21/45 ,  G01N21/553 ,  G01N21/645

摘要： A method of probing a plurality of analyzer molecules distributed about a detection platform is disclosed. The method includes contacting a test sample to the plurality of analyzer molecules, scanning the plurality of analyzer molecules at a rate relating to a carrier frequency signal, and detecting the presence or absence of a biological molecule based at least in part upon the presence or absence of a signal substantially at a sideband of the carrier frequency signal. A molecule detection platform including a substrate and a plurality of targets positioned about the substrate is also disclosed. Specific analyzer molecules adapted to bind a specific analyte are immobilized about a first set of the targets. Nonspecific analyzer molecules are immobilized about a second set of the targets. The targets positioned about the substrate along at least a segment of a scanning pathway alternate between at least one of the first set and at least one of the second set. A method including providing a substrate for supporting biological analyzer molecules the substrate including at least one scanning pathway is also disclosed. The scanning pathway includes a plurality of scanning targets. Specific biological analyzer molecules adapted to detect a specific target analyte are distributed about a first set of the targets which alternate in groups of at least one with a second set of the targets the second set of the targets not including the specific biological analyzer molecules.

摘要翻译： 公开了一种探测分布在检测平台周围的多个分析器分子的方法。 该方法包括使测试样本与多个分析器分子接触，以与载波频率信号相关的速率扫描多个分析器分子，并且至少部分地基于存在或不存在检测生物分子的存在或不存在 基本上在载波频率信号的边带处的信号。 还公开了一种分子检测平台，其包括基板和围绕基板定位的多个靶。 适于结合特定分析物的特异性分析仪分子被固定在第一组靶上。 非特异性分析仪分子被固定在第二组靶上。 沿着扫描通道的至少一段定位在基底周围的靶在第一组和第二组中的至少一个之间交替。 还公开了一种包括提供用于支持生物分析器分子的基板的方法，所述基板包括至少一个扫描路径。 扫描路径包括多个扫描目标。 适于检测特定目标分析物的特异性生物分析仪分子围绕第一组靶标分布，其中至少一组与第二组靶标交替，第二组靶标不包括特定生物分析仪分子。

公开(公告)号：US20120014697A1

公开(公告)日：2012-01-19

申请号：US13240910

申请日：2011-09-22

申请人： Ming Zhao ,  Jianjun Chen ,  Xueru Liu ,  Pinghua He

发明人： Ming Zhao ,  Jianjun Chen ,  Xueru Liu ,  Pinghua He

IPC分类号： H04B10/00

CPC分类号： H04B1/38 ,  H01Q1/246 ,  H01Q21/062 ,  H01Q21/28 ,  H04W88/085

摘要： An antenna device is provided, which includes a first antenna unit and a second antenna unit. The first antenna unit includes a first radiation module, a power divider/combiner network connected to the first radiation module, and a feeder interface connected to the power divider/combiner network. The feeder interface is connected to a radio remote unit (RRU) or a macro base station through a feeder. The second antenna unit includes a second radiation module, a transceiver array connected to the second radiation module, a baseband processing unit (BPU) connected to the transceiver array, and an optical fiber interface connected to the BPU. The optical fiber interface is connected to a baseband unit (BBU) through an optical fiber. Therefore, after the existing passive antenna is replaced by the provided antenna device, the RRU or macro base station in the original network can still be used, which reduces waste of resources.

摘要翻译： 提供一种天线装置，其包括第一天线单元和第二天线单元。 第一天线单元包括第一辐射模块，连接到第一辐射模块的功率分配器/组合器网络，以及连接到功率分配器/组合器网络的馈线接口。 馈线接口通过馈线连接到无线电远程单元（RRU）或宏基站。 第二天线单元包括第二辐射模块，连接到第二辐射模块的收发器阵列，连接到收发器阵列的基带处理单元（BPU）和连接到BPU的光纤接口。 光纤接口通过光纤连接到基带单元（BBU）。 因此，在现有无源天线被所提供的天线设备替代之后，仍然可以使用原始网络中的RRU或宏基站，从而减少资源的浪费。

公开(公告)号：USD645493S1

公开(公告)日：2011-09-20

申请号：US29381828

申请日：2010-12-23

申请人： Ming Zhao

设计人： Ming Zhao

公开(公告)号：USD645492S1

公开(公告)日：2011-09-20

申请号：US29381307

申请日：2010-12-17

申请人： Ming Zhao

设计人： Ming Zhao

公开(公告)号：US07659968B2

公开(公告)日：2010-02-09

申请号：US12018108

申请日：2008-01-22

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N21/00 ,  G01N21/64

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

公开(公告)号：US20090300779A1

公开(公告)日：2009-12-03

申请号：US11631247

申请日：2005-06-29

申请人： Ming Zhao ,  Meng Yang

发明人： Ming Zhao ,  Meng Yang

IPC分类号： A01K67/00 ,  C12N1/21 ,  A61K35/74 ,  A61K39/40 ,  C12N9/00

CPC分类号： A61K35/74 ,  A61K38/2013 ,  A61K38/51

摘要： Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model.

摘要翻译： 在至少一种肿瘤中发现的至少两种氨基酸营养缺陷型细菌是有效的抗肿瘤治疗，标记试剂和针对感染的疫苗。 也可以通过适当的肿瘤模型通过这些菌株提供改善的抗肿瘤作用。

公开(公告)号：US07493688B1

公开(公告)日：2009-02-24

申请号：US11352536

申请日：2006-02-13

申请人： Lei Wang ,  Liping Ren ,  Yingjian Chen ,  Christopher T. Ngo ,  Ming Zhao

发明人： Lei Wang ,  Liping Ren ,  Yingjian Chen ,  Christopher T. Ngo ,  Ming Zhao

IPC分类号： G11B5/127 ,  H04R31/00

CPC分类号： G11B5/3163 ,  G11B5/3116 ,  Y10T29/49041 ,  Y10T29/49043 ,  Y10T29/49046 ,  Y10T29/49048 ,  Y10T29/49052

摘要： A method for providing a magnetic recording transducer is disclosed. The method includes providing a first pole having front and rear portions and a back gap on the rear portion. The method also includes providing an insulator on the first pole. The method includes providing a write gap and providing a portion of a second pole on at least the write gap. A portion of the write gap resides on the front portion of the first pole. A portion of the insulator covers a portion of the first pole between the portion of the second pole and the back gap. The method also includes providing a mask that covers the back gap and exposes the portion of the second pole and the insulator. The method also includes performing a pole trim that can substantially remove the portion of the insulator covering the remaining portion of the first pole.

摘要翻译： 公开了一种用于提供磁记录换能器的方法。 该方法包括提供具有前部和后部的第一极和后部上的后部间隙。 该方法还包括在第一极上提供绝缘体。 所述方法包括提供写入间隙并且在至少所述写入间隙上提供第二极点的一部分。 写入间隙的一部分位于第一极的前部。 绝缘体的一部分覆盖第二极的部分和后间隙之间的第一极的一部分。 该方法还包括提供覆盖后隙并且暴露第二极和绝缘体的部分的掩模。 该方法还包括执行极性修剪，其可以基本上去除覆盖第一极的剩余部分的绝缘体的部分。

公开(公告)号：US20080198808A1

公开(公告)日：2008-08-21

申请号：US12034706

申请日：2008-02-21

申请人： Seong-Taek HWANG ,  Shuangfeng Han ,  Chunhui Zhou ,  Jing Wang ,  Ming Zhao ,  Zheng Xu

发明人： Seong-Taek HWANG ,  Shuangfeng Han ,  Chunhui Zhou ,  Jing Wang ,  Ming Zhao ,  Zheng Xu

IPC分类号： H04Q7/00

CPC分类号： H04W36/06 ,  H04W88/085

摘要： Disclosed is a system and a method for performing handover in a Worldwide interoperability for Microwave Access (WiMAX) mobile communication system supporting broadband wireless access. The system includes a plurality of Mobile Stations (MSs); at least one distributed antenna having the ability to perform simultaneous communications with the plurality of MSs; and a base station connected to the at least one distributed antenna through optical fibers for performing communications and handovers with the multiple MSs.

摘要翻译： 公开了一种在支持宽带无线接入的全球微波接入（WiMAX）移动通信系统互操作性中进行切换的系统和方法。 该系统包括多个移动站（MS）; 至少一个具有与所述多个MS同时通信的能力的分布式天线; 以及通过光纤连接到所述至少一个分布式天线的基站，用于执行与所述多个MS的通信和切换。

公开(公告)号：US20070212257A1

公开(公告)日：2007-09-13

申请号：US11675359

申请日：2007-02-15

申请人： David Nolte ,  Manoj Varma ,  Ming Zhao

发明人： David Nolte ,  Manoj Varma ,  Ming Zhao

IPC分类号： G01N21/00

CPC分类号： G01N21/45 ,  G01N21/253 ,  G01N21/47 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/4707 ,  G01N2021/7773 ,  G01N2021/7779

摘要： Method and apparatus for use with a probe beam and detector for detecting the presence of a target analyte in a sample. The apparatus includes a substrate; and a biolayer located on the substrate designed to react to target analyte when the sample is deposited on the biolayer. The substrate can be selected to substantially minimize reflectance by the substrate while substantially maintaining scattering by the target analyte. The substrate can be designed so waves reflected by the substrate are substantially in quadrature with waves scattered by target analyte; or so waves reflected by the substrate and scattered by target analyte interfere in the far field and directly create intensity modulation detectable by the detector. The biolayer can include a plurality of spots, and the spots can be grouped into unit cells having specific antibodies and non-specific antibodies for reacting with target analyte.

摘要翻译： 用于探测束和检测器的用于检测样品中目标分析物的存在的方法和装置。 该装置包括基板; 以及位于衬底上的生物层，设计成当样品沉积在生物层上时与靶分析物反应。 可以选择衬底以基本上最小化衬底的反射率，同时基本上保持靶分析物的散射。 可以设计衬底，使得由衬底反射的波基本上与被靶分析物散射的波正交; 由基板反射并被目标分析物散射的波浪会在远场干扰，并直接产生由检测器可检测的强度调制。 生物层可以包括多个斑点，并且斑点可以分组成具有特异性抗体的单位细胞和用于与靶分析物反应的非特异性抗体。

公开(公告)号：US20060233439A1

公开(公告)日：2006-10-19

申请号：US11349046

申请日：2006-02-07

申请人： Ming Zhao

发明人： Ming Zhao

IPC分类号： G06K9/00

CPC分类号： H04N9/045 ,  G06T5/005 ,  G06T5/20 ,  G06T2207/10024 ,  H04N2209/045

摘要： A method and apparatus for processing a Bayer-pattern color digital image signal are provided. The apparatus includes: a first defect detector generating first defect information of a first pixel to be processed from input image data; a second defect detector generating second defect information and horizontal and vertical gradients of the first pixel from the input image data; and a corrector compensating for a center-point defect, a thin line defect, or an edge defect in the first pixel according to the horizontal and vertical gradients using the first and second defect information to output corrected image data.

摘要翻译： 提供了一种处理拜耳图案彩色数字图像信号的方法和装置。 该装置包括：第一缺陷检测器，从输入图像数据生成要处理的第一像素的第一缺陷信息; 第二缺陷检测器，从输入图像数据生成第一缺陷信息和第一像素的水平和垂直梯度; 以及校正器，使用第一和第二缺陷信息根据水平和垂直梯度补偿第一像素中的中心点缺陷，细线缺陷或边缘缺陷，以输出校正图像数据。