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    Method for realizing the multicast service
    11.
    发明授权
    Method for realizing the multicast service 有权
    实现组播业务的方法

    公开(公告)号：US07830825B2

    公开(公告)日：2010-11-09

    申请号：US10590375

    申请日：2005-03-24

    Applicant: Yan Fu ,  Haitao Hu

    Inventor： Yan Fu ,  Haitao Hu

    IPC: H04H20/71

    CPC classification number: H04L12/185 ,  H04L29/12009 ,  H04L29/12783 ,  H04L61/35 ,  H04L63/101 ,  H04L63/104

    Abstract: The present invention discloses a method for implementing multicast services, which includes: preset a mapping relation between a multicast user address and a multicast group address; acquire a request packet sent by the multicast user who requests to join in the multicast group; determine whether the multicast group address in request packet is the same as that corresponding to the multicast user in the established mapping relation according to the multicast user address and multicast group address carried in the request packet. If yes, allow the multicast user to join in the multicast group. Otherwise, prohibit the multicast user from joining in the multicast group. The present invention can open the preset multicast resources to the preset multicast user with speed and pertinence. At the same time, it limits the maximum number of multicast groups that each multicast user is allowed to join in, which can effectively control multicast service bandwidth and further protect the network equipment.

    Abstract translation: 本发明公开了一种实现组播业务的方法，包括：预先配置组播用户地址与组播组地址之间的映射关系; 获取请求加入组播组的组播用户发送的请求报文; 根据组播用户地址和请求包中携带的组播组地址，确定请求报文中的组播组地址是否与建立的映射关系中的组播用户对应的组播组地址相同。 如果是，允许组播用户加入组播组。 否则，禁止组播用户加入组播组。 本发明能够以预定的组播用户的速度和针对性开放预设的组播资源。 同时限制了每个组播用户可以加入的组播组的最大数量，从而有效地控制组播业务带宽，进一步保护网络设备。

    CONJUGATE COMPRISING ANGIOSTATION OR ITS FRAGMENT, THE METHOD FOR PRODUCING THE CONJUGATE AND USE THEREOF
    12.
    发明申请
    CONJUGATE COMPRISING ANGIOSTATION OR ITS FRAGMENT, THE METHOD FOR PRODUCING THE CONJUGATE AND USE THEREOF 审中-公开
    包含放射性物质或其碎片的方法，其生产方法和使用方法

    公开(公告)号：US20100184661A1

    公开(公告)日：2010-07-22

    申请号：US12522661

    申请日：2008-01-10

    Applicant: Yongzhang Luo ,  Guodong Chang ,  Shuling Yang ,  Lei Gao ,  Yan Fu

    Inventor： Yongzhang Luo ,  Guodong Chang ,  Shuling Yang ,  Lei Gao ,  Yan Fu

    IPC: A61K38/17 ,  C07K17/08 ,  A61P35/00 ,  C07K1/00

    CPC classification number: A61K47/60 ,  C12N9/6435 ,  C12Y304/21007

    Abstract: The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms.

    Abstract translation: 本发明提供抗肿瘤或抗血管生成药物，含有该药物的组合物或试剂盒及其制备方法。 抗肿瘤或抗血管生成药物含有包含修饰剂和血管抑素或其片段的缀合物，其中与未修饰的血管抑素或其片段相比，缀合物表现出延长的体内半衰期。 改性剂选自高分子聚合物，蛋白质分子或其片段，肽，小分子或任何其它形式的化学物质。

    Method of identifying an open reading frame using a nucleic acid molecule encoding multiple start codons and histidine tags
    13.
    发明授权
    Method of identifying an open reading frame using a nucleic acid molecule encoding multiple start codons and histidine tags 失效
    使用编码多个起始密码子和组氨酸标签的核酸分子鉴定开放阅读框的方法

    公开(公告)号：US07056672B2

    公开(公告)日：2006-06-06

    申请号：US10766102

    申请日：2004-01-27

    Applicant: Patrick S. Schnable ,  Feng Liu ,  Yan Fu

    Inventor： Patrick S. Schnable ,  Feng Liu ,  Yan Fu

    IPC: C12Q1/68 ,  C12P21/00 ,  C12P21/02

    CPC classification number: C12N15/1086 ,  C07K2319/21 ,  C12N15/1065 ,  C12N15/62

    Abstract: Compositions and methods for identifying nucleotide fragments that contain an open reading frame are provided. Compositions comprise a nucleotide sequence that encodes, in each of the three possible reading frames, an ATG start codon and a histidine tag, and vectors comprising such a nucleotide sequence. The vectors may be provided with cloning sites for insertion of nucleotide sequences of interest 5′ or 3′ to the 3-frame His-tag DNA sequence. Vectors also are provided with cloning sites for inserting nucleotide sequences of interest 3′ of the ATG start codon and 5′ of the 3-frame His-tag DNA sequence.

    Abstract translation: 提供了用于鉴定包含开放阅读框架的核苷酸片段的组合物和方法。 组合物包含在三个可能的阅读框中的每一个中编码ATG起始密码子和组氨酸标签的核苷酸序列，以及包含这种核苷酸序列的载体。 可以向载体提供用于将感兴趣的5'或3'的核苷酸序列插入3框架His标签DNA序列的克隆位点。 载体还提供有用于插入ATG起始密码子的3'和3框His标签DNA序列的5'的感兴趣的核苷酸序列的克隆位点。

    USE OF NUCLEOLIN AS A BIOMARKER FOR LYMPHANGIOGENESIS IN CANCER PROGNOSIS AND THERAPY
    17.
    发明申请
    USE OF NUCLEOLIN AS A BIOMARKER FOR LYMPHANGIOGENESIS IN CANCER PROGNOSIS AND THERAPY 审中-公开
    作为生物标记物的核蛋白用于癌症预防和治疗中的淋巴细胞生成

    公开(公告)号：US20130023479A1

    公开(公告)日：2013-01-24

    申请号：US13554913

    申请日：2012-07-20

    Applicant: Yongzhang Luo ,  Wei Zhuo ,  Yan Fu ,  Guodong Chang

    Inventor： Yongzhang Luo ,  Wei Zhuo ,  Yan Fu ,  Guodong Chang

    IPC: G01N33/574 ,  A61K38/17 ,  A61P35/04 ,  C40B30/04

    CPC classification number: G01N33/574 ,  A61K38/39 ,  C07K16/28 ,  C07K2317/76 ,  G01N2333/515 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/7014

    Abstract: The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor metastasis. The present invention also relates to a new approach, which uses nucleolin as a bait to search and screen for lymphangiogenesis inhibitors or cancer suppressors, which function in a manner that is analogous to endostatin. The invention is based upon the discovery that nucleolin is specifically expressed on lymphangiogenic vessels and functions as a specific receptor for endostatin, and thus is involved in the signal transduction pathway of endostatin as an anti-lymphangiogenesis inhibitor. The present invention also discloses that cell surface nucleolin on lymphatic endothelial cells is a biomarker for lymphangiogenic vessels, which could be used for the prediction of tumor metastasis.

    Abstract translation: 本发明涉及鉴定适合于抗淋巴管生成治疗以预防肿瘤生长和肿瘤转移的癌症受试者，特别是人类患者的方法。 本发明还涉及使用核仁林作为诱饵来搜索和筛选淋巴管生成抑制剂或癌抑制因子的新方法，其以类似于内皮抑素的方式起作用。 本发明基于以下发现：核仁林在淋巴管生成血管上特异性表达，并且作为内皮抑制素的特异性受体起作用，因此参与作为抗淋巴管生成抑制剂的内皮抑素的信号转导途径。 本发明还公开了淋巴管内皮细胞上的细胞表面核仁素是淋巴管生成血管生物标志物，可用于预测肿瘤转移。

    Method and Apparatus for Selecting Network Services
    18.
    发明申请
    Method and Apparatus for Selecting Network Services 有权
    选择网络服务的方法和设备

    公开(公告)号：US20110219127A1

    公开(公告)日：2011-09-08

    申请号：US12716099

    申请日：2010-03-02

    Applicant: Yan Fu

    Inventor： Yan Fu

    IPC: G06F15/16

    CPC classification number: G06F15/16

    Abstract: An approach is provided for selecting a network server. An apparatus comprising at least one processor, and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor, cause, at least in part, the apparatus to load from one or more network servers configuration information of one or more network servers used by a service provider network. The apparatus is also caused to select a network server in the service provider network based at least in part on at least one of network server latency and the network server load. The apparatus is further caused to set the network server as default network server used for at least one of current and future session on one or more user equipment.

    Abstract translation: 提供了一种用于选择网络服务器的方法。 一种装置，包括至少一个处理器，以及包括计算机程序代码的至少一个存储器，所述至少一个存储器和所述计算机程序代码被配置为与所述至少一个处理器一起至少部分地使所述装置从 服务提供商网络使用的一个或多个网络服务器的一个或多个网络服务器配置信息。 该设备还被引导以至少部分地基于网络服务器延迟和网络服务器负载中的至少一个来在服务提供商网络中选择网络服务器。 进一步使设备将网络服务器设置为在一个或多个用户设备上用于当前和将来会话中的至少一个的默认网络服务器。

    METHOD AND APPARATUS FOR PROVIDING A SCALABLE SERVICE PLATFORM USING A NETWORK CACHE
    19.
    发明申请
    METHOD AND APPARATUS FOR PROVIDING A SCALABLE SERVICE PLATFORM USING A NETWORK CACHE 有权
    使用网络缓存提供可扩展服务平台的方法和装置

    公开(公告)号：US20100332834A1

    公开(公告)日：2010-12-30

    申请号：US12495071

    申请日：2009-06-30

    Applicant: Yan Fu ,  Ari M. Vepsalainen ,  Ari Antero Aarnio ,  Markku Kalevi Vimpari ,  Pekka Laitinen

    Inventor： Yan Fu ,  Ari M. Vepsalainen ,  Ari Antero Aarnio ,  Markku Kalevi Vimpari ,  Pekka Laitinen

    IPC: H04L9/32 ,  H04L9/08

    CPC classification number: H04L9/08 ,  H04L9/0822 ,  H04L2209/60 ,  H04L2209/80

    Abstract: An approach is provided for building a scalable service platform by initiating transmission of encrypted data from a public network cache. An access control server platform determines a first authorization key for a user and a second authorization key for a resource, and then encrypts the resource with the second authorization key, and encrypts the second authorization key with the first authorization key. The access control server platform initiates distribution of the encrypted second authorization key with the encrypted resource over a network. The access control server platform further initiates caching the encrypted second authorization key with the encrypted resource that meets a predefined threshold value (e.g., a data size, an access frequency, a modification frequency, or an auditing requirement) in a cache in the network, and initiates transmission of the cached and encrypted second authorization key with the cached and encrypted resource from the cache to at least one authorized entity.

    Abstract translation: 提供了一种通过从公共网络缓存发起加密数据来构建可扩展服务平台的方法。 访问控制服务器平台确定用户的第一授权密钥和用于资源的第二授权密钥，然后用第二授权密钥对资源进行加密，并用第一授权密钥加密第二授权密钥。 访问控制服务器平台通过网络启动加密的第二授权密钥与加密的资源的分发。 访问控制服务器平台进一步发起加密的第二授权密钥与加密资源缓存，该加密的资源满足网络中的高速缓存中的预定阈值（例如，数据大小，访问频率，修改频率或审核要求） 并且启动具有缓存和加密的资源的缓存和加密的第二授权密钥从高速缓存传输到至少一个授权实体。

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