公开(公告)号：US5624727A

公开(公告)日：1997-04-29

申请号：US355657

申请日：1994-12-14

申请人： Vladimir A. Stoy

发明人： Vladimir A. Stoy

IPC分类号： A61L29/14 ,  A61L31/14 ,  B32B9/00

CPC分类号： A61L29/14 ,  A61L31/14 ,  Y10S428/913 ,  Y10T428/23 ,  Y10T428/231 ,  Y10T428/234 ,  Y10T428/239

摘要： This application describes devices which have a first softer formable state, and the second stiffer shape-retaining shape and which are capable of repeatable transition from the first state to the second state (or vice versa) on demand. The device comprises:(a) a hollow body having at least partial flexibility and being capable of containing a plurality of particular material therein;(b) a plurality of particular material permanently located within said hollow body;(c) a fluid medium in the hollow body and intermixed with the particulate material when the device is in its first state, and removed at least partly from the hollow body and the particulate material when the device is in its second state;(d) fluid transfer means for removing the fluid medium from the hollow body and the particulate material or to return the fluid medium thereto in a predetermined manner, thereby being adapted to transform the device from the first state to the second state and vice versa; and,(e) a fluid medium receptor located within said hollow body and connected to said fluid transfer means. As the fluid medium is transferred out of the hollow body, the individual elements of the particulate material are becoming capable of mutual interaction and the device gets into its second, shape-retaining shape. p1 As a rule, the fluid medium can be transferred into (or from) a fluid medium receiver. The receiver is advantageously located within the hollow body.

摘要翻译： 该应用描述了具有第一较软可形成状态的装置，以及第二更硬的形状保持形状，并且能够根据需要从第一状态到第二状态（或反之亦然）重复地转变。 该装置包括：（a）具有至少部分柔性并且能够在其中容纳多个特定材料的中空本体; （b）永久地位于所述中空体内的多个特定材料; （c）当所述装置处于其第一状态时，所述中空体中的流体介质和所述颗粒材料混合，并且当所述装置处于其第二状态时，至少部分地从所述中空体和所述颗粒材料中去除; （d）流体传送装置，用于从中空体和颗粒材料中去除流体介质，或者以预定的方式将流体介质返回到其中，从而适于将装置从第一状态转换到第二状态，反之亦然; 和（e）位于所述中空体内并连接到所述流体传送装置的流体介质接收器。 当流体介质从中空体转移出来时，颗粒材料的各个元件变得能够相互作用，并且该装置进入其第二形状保持形状。 p1通常，流体介质可以转移到（或从）流体介质接收器中。 接收器有利地位于中空体内。

公开(公告)号：US5159360A

公开(公告)日：1992-10-27

申请号：US556329

申请日：1990-07-17

申请人： Vladimir A. Stoy ,  Jan Lovy ,  George P. Stoy

发明人： Vladimir A. Stoy ,  Jan Lovy ,  George P. Stoy

IPC分类号： G02B1/04 ,  G02C7/04

CPC分类号： G02B1/043 ,  G02C7/04

摘要： The present invention contact lens is a soft, disposable lens which, under eye wearer conditions, changes one or more characteristics essential for comfortable use, at a predetermined time to initiate disposal thereof by the user. This lens, under wear conditions, changes, for example, at least its base curve redius and its deformability as a consequence of a change in hydrophilicity of at least a portion of the contact lens material. This hydrophilicity change may be achieved by various means, e.g. degradation of crosslinking bridges or conversion of less hydrophilic groups to groups having greater hydrophilicity. In one preferred embodiment, the conversion is achieved by hydrolysis of selected functional (hydrophobic) groups into hydrophilic groups.

摘要翻译： 本发明的隐形眼镜是一种柔软的一次性透镜，其在眼睛佩戴者的条件下，在预定的时间改变用于舒适使用所必需的一个或多个特征以开始用户的处置。 这种透镜在磨损条件下，例如由于隐形眼镜材料的至少一部分的亲水性变化而至少改变其基线曲线及其变形能力。 这种亲水性变化可以通过各种方式实现，例如， 交联桥的降解或较少亲水基团转化为具有较大亲水性的基团。 在一个优选的实施方案中，通过将选择的官能（疏水）基团水解成亲水基团来实现转化。

公开(公告)号：US4379874A

公开(公告)日：1983-04-12

申请号：US166032

申请日：1980-07-07

申请人： Vladimir A. Stoy

发明人： Vladimir A. Stoy

IPC分类号： C08F8/00 ,  C08F293/00 ,  C08L33/20 ,  C08L53/00

CPC分类号： C08F293/00 ,  C08F8/00 ,  C08L33/20

摘要： There is disclosed a process for producing a novel polymer composition comprised of a polyacrylonitrile polymer and a block copolymer with acrylonitrile and non-crystalline polymer sequences wherein the polymer composition is formed by the removal of a solvent from a solution of a polyacrylonitrile polymer and a block copolymer with acrylonitrile and non-crystalline polymer sequences.

摘要翻译： 公开了一种由聚丙烯腈聚合物和具有丙烯腈和非结晶聚合物序列的嵌段共聚物组成的新型聚合物组合物的方法，其中通过从聚丙烯腈聚合物和嵌段的溶液中除去溶剂而形成聚合物组合物 共聚物与丙烯腈和非结晶聚合物序列。

公开(公告)号：US4370451A

公开(公告)日：1983-01-25

申请号：US346417

申请日：1982-02-08

申请人： Vladimir A. Stoy

发明人： Vladimir A. Stoy

IPC分类号： C08F8/00 ,  C08F293/00 ,  C08F220/48

CPC分类号： C08F293/00 ,  C08F8/00

摘要： There is disclosed novel block copolymers formed of acrylonitrile sequences and sequences containing at least about 50 mole percent of acrylamide units and at most about 50 mole percent organo-substituted amide units and formed by reacting a block copolymer having acrylonitrile sequences and sequences of glutarimide units with a low molecular weight compound having a functional group selected from the group consisting of primary amino and secondary amino group. The reaction is effected at a pH of about 7.5 and higher, preferably in the presence of a solvent and/or swelling agent.

摘要翻译： 公开了由丙烯腈序列和含有至少约50摩尔％的丙烯酰胺单元和至多约50摩尔％的有机取代的酰胺单元的序列形成的新型嵌段共聚物，并通过使具有丙烯腈序列和戊二酰亚胺单元序列的嵌段共聚物与 具有选自伯氨基和仲氨基的官能团的低分子量化合物。 反应在约7.5℃或更高的pH下进行，优选在溶剂和/或溶胀剂的存在下进行。

公开(公告)号：US4337327A

公开(公告)日：1982-06-29

申请号：US188060

申请日：1980-09-17

申请人： Vladimir A. Stoy

发明人： Vladimir A. Stoy

IPC分类号： C08F8/00 ,  C08F293/00 ,  C08F220/48

CPC分类号： C08F293/00 ,  C08F8/00 ,  Y10S524/916

摘要： There is disclosed novel block copolymers formed of acrylonitrile sequences and sequences containing at least about 50 mole percent of acrylamide units and at most about 50 of units selected from the group consisting of carboxyl, ester, amide, hydrazide and hydroxylamide units and formed by reacting a block copolymer having acrylonitrile sequences and sequences of glutarimide units with a low molecular weight compound having a functional group selected from the group consisting of hydroxyl, primary amino, secondary amino, hydrazo and hydroxylamino group. The reaction is effected at a pH of about 7.5 and higher, preferably in the presence of a solvent and/or swelling agent.

摘要翻译： 公开了由丙烯腈序列和含有至少约50摩尔％的丙烯酰胺单元和至多约50个选自羧基，酯，酰胺，酰肼和羟基酰胺单元的单元的序列形成的新型嵌段共聚物，并通过使 具有丙烯腈序列的嵌段共聚物和具有选自羟基，伯氨基，仲氨基，羟基和羟基氨基的官能团的低分子量化合物的戊二酰亚胺单元的序列。 反应在约7.5℃或更高的pH下进行，优选在溶剂和/或溶胀剂的存在下进行。

公开(公告)号：US5252692A

公开(公告)日：1993-10-12

申请号：US617177

申请日：1990-11-23

申请人： Jan Lovy ,  Vladimir A. Stoy

发明人： Jan Lovy ,  Vladimir A. Stoy

IPC分类号： C08F8/32 ,  C08F220/52

CPC分类号： C08F8/32 ,  C08F2800/10 ,  C08F2810/20

摘要： Novel amphoteric acrylic and methacrylic copolymers are described comprising cationic units of pendant N-substituted amidine and anionic units of acrylic or methacrylic acid and/or acidic groups carried by substituents of N-acrylamide, N-methacrylamide, N-acrylamidine or N-methacrylamidine. One preferred embodiment is a copolymer in which at least some types of functional groups are organized in blocks. Particularly preferred are blocks of pendant nitrile groups. Preferred compositions have the said N-substituents of the amides and/or amidines containing polar groups other than primary amines. Particularly preferred polar groups are tertiary amines, quaternary ammonium salts, hydroxyls and sulfonic acid. These copolymers may optionally be convalently or physically crosslinked and swellable rather than soluble in water. A method of preparing said amphoteric acrylic and methacrylic copolymers is described comprising the reaction of selected polymers with a multitude of pendant CN groups in mutual 1,3 positions with a primary amine in presence of water. One preferred method is the reaction of CN groups with the primary amine and water in the presence of a solvent of the said polymer and/or in the presence of a basic catalyst. The particularly preferred embodiment is a reaction of CN groups containing polymer dissolved in a mixture of the polymer solvent, a primary amine, water and an optional basic catalyst.

摘要翻译： 描述了新型两性丙烯酸和甲基丙烯酸共聚物，其包括N-取代脒侧基的阳离子单元和由N-丙烯酰胺，N-甲基丙烯酰胺，N-丙烯酰脒或N-甲基脒基的取代基所携带的丙烯酸或甲基丙烯酸和/或酸性基团的阴离子单元。 一个优选实施方案是其中至少一些类型的官能团以块形式组织的共聚物。 特别优选的是侧基腈基团。 优选的组合物具有除伯胺之外的含有极性基团的酰胺和/或脒的所述N-取代基。 特别优选的极性基团是叔胺，季铵盐，羟基和磺酸。 这些共聚物可以任选地是共价的或物理上交联的和可溶胀的而不是可溶于水。 描述制备所述两性丙烯酸和甲基丙烯酸共聚物的方法，其包括在存在水的情况下，将选定的聚合物与多个相互1,3位的侧基CN基团与伯胺反应。 一种优选的方法是在所述聚合物的溶剂存在下和/或在碱性催化剂的存在下，CN基团与伯胺和水的反应。 特别优选的实施方案是含有聚合物的CN基团溶解在聚合物溶剂，伯胺，水和任选的碱性催化剂的混合物中的反应。

公开(公告)号：US5217026A

公开(公告)日：1993-06-08

申请号：US864472

申请日：1992-04-06

申请人： George P. Stoy ,  Vladimir A. Stoy

发明人： George P. Stoy ,  Vladimir A. Stoy

IPC分类号： A61M25/00

CPC分类号： A61M25/0045 ,  A61M25/0009 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09091 ,  A61M2025/09108 ,  Y10S524/916

摘要： The present invention guidewire involves an elongated, non-hydrogel core element forming an inner part of the device, and an integral outside tubular layer of elastomeric hydrogel ("hydrogel sleeve"). This outer hydrogel layer has unique physical characteristics. They are (a) Gradient of chemical composition with increasing concentration of polar groups in the outward direction away from the core element; (b) Gradient of swelling in contact with water with water content increasing in the outward direction away from the core element; (c) Compressive stress in the outer hydrophilic layer causing the hydrogel in that layer to swell to a water content lower than its equilibrium value in a free-swelling state; and, optionally, (d) Inward-directed radial stress pushing the outside hydrogel layer constantly against the inner core element. The present invention also involves the methods of making these guidewires, including melt extrusion directly onto the core element, coagulation from solution, in situ hydrogel polymer formation, and tubing extrusion followed by consequent shrink-fit over the core.

摘要翻译： 本发明的导丝涉及形成装置的内部的细长的非水凝胶芯元件和弹性体水凝胶（“水凝胶套”）的整体的外部管状层。 该外部水凝胶层具有独特的物理特征。 它们是（a）化学成分的梯度随着极性基团浓度越来越远离核心元素的向外方向; （b）与水接触的膨胀梯度，水分含量沿远离核心元件的向外方向增加; （c）外层亲水层中的压缩应力使得该层中的水凝胶在游离溶胀状态下膨胀至低于其平衡值的水含量; 和（d）向内的径向应力将外部水凝胶层不断地推靠在内芯元件上。 本发明还涉及制造这些导线的方法，包括直接熔融挤出到芯元件上，从溶液凝结，原位水凝胶聚合物形成和管材挤出，随后在芯上收缩配合。

公开(公告)号：US5037178A

公开(公告)日：1991-08-06

申请号：US464187

申请日：1990-01-12

申请人： Vladimir A. Stoy ,  Francis T. Delahanty

发明人： Vladimir A. Stoy ,  Francis T. Delahanty

IPC分类号： B29C35/04 ,  B29C61/00 ,  B29C61/06 ,  C08L101/00 ,  G01B5/25 ,  G02B6/00 ,  G02B6/38

CPC分类号： B29C61/003 ,  B29C61/06 ,  G01B5/25 ,  G02B6/3803 ,  G02B6/3865 ,  B29C35/049 ,  Y10T428/1328

摘要： The present invention is directed to a device and method for precise positioning, or alignment of one or more articles with respect to the device or to each other. The device comprises one or more elements of Unistructural Mass of Inherent Memory Polymer with one or more internal cavities which have inherent shapes with at least one cross-sectional configuration which is congruent to a cross-sectional configuration shape of the said article(s) in the positioned or aligned position(s). The unistructural mass has cross-sectional configurations which are the same or smaller than those corresponding to the positions of the articles. The unistructural mass is deformed such that the articles can be readily inserted into the corresponding cavities. In one embodiment, a single unistructural mass has a single cavity for precision positioning of the article. In another embodiment, the mass has at least two cavities for article alignment. In another embodiment, a plurality of unistructural masses are aligned or connected and each contains at least one such cavity. Once the articles are inserted into their corresponding cavities, the inherent memory polymer is returned to its inherent shape by non-mechanical stimulus to force the articles into precisely defined position.

摘要翻译： 本发明涉及一种用于相对于装置或彼此精确地定位或对准一个或多个物品的装置和方法。 该装置包括具有一个或多个内部空腔的一个或多个具有一个或多个内部空腔的非结构质量的元件，所述内部空腔具有至少一个横截面构造的固有形状，其与所述制品的横截面构造形状一致， 定位或对准的位置。 非结构性物质具有与制品的位置对应的截面构造相同或更小的横截面构造。 非结构物质变形，使得制品能够容易地插入到相应的空腔中。 在一个实施例中，单一的非结构物质具有用于制品的精确定位的单个腔。 在另一个实施例中，该物质具有用于制品对准的至少两个空腔。 在另一个实施例中，多个非结构质量对齐或连接，并且每个都包含至少一个这样的空腔。 一旦物品被插入其相应的空腔中，固有的记忆聚合物通过非机械刺激返回到其固有的形状，以迫使制品进入精确限定的位置。

公开(公告)号：US4969705A

公开(公告)日：1990-11-13

申请号：US467511

申请日：1990-01-19

申请人： Vladimir A. Stoy ,  Francis T. Delahanty

发明人： Vladimir A. Stoy ,  Francis T. Delahanty

IPC分类号： G02B1/04 ,  G02B6/28 ,  G02B6/38

CPC分类号： G02B6/2804 ,  G02B1/048 ,  G02B6/3806

摘要： The present invention involves a multiple cavity optical fiber splice made of a unistructural mass of inherent shape memory polymer material. The unistructural mass has a longitudinal dimension with opposite ends which includes at least a first bore at one end and at least a second bore and a third bore at the other end wherein the bores go into the mass and at least two connect to each other. The unistructural mass has two shapes, the first shape is a unique, recoverable, predetermined inherent shape wherein each bore has a preset diameter to accommodate and tightly hold end segments of denuded optical fibers of predetermined diameter and the second shape is a deformed shape which may be caused by solvent swelling and partial shrinking of the inherent memory polymer material such that each bore has enlarged predetermined diameters greater than the diameters of the segments of the denuded optical fibers so as to freely receive the end segments of the denuded optical fibers. The mass may be initially formed in the first shape, and may be then swollen and shrunk to its second shape. It is capable of being returned to its first shape by application of a non-mechanical stimulus.

摘要翻译： 本发明涉及由固有形状记忆聚合物材料的非结构物质制成的多腔光纤接头。 该非结构物质具有相对端的纵向尺寸，该纵向尺寸至少包括一端的第一孔和至少一个第二孔，另一端包括第三孔，其中孔进入质量并且至少两个相互连接。 非结构质量具有两种形状，第一形状是独特的，可恢复的，预定的固有形状，其中每个孔具有预定直径以容纳并紧密地保持预定直径的裸露光纤的端部段，并且第二形状是变形形状， 由固有的记忆聚合物材料的溶剂膨胀和部分收缩引起，使得每个孔具有比已解开的光纤的段的直径大的预定直径的扩大，以便自由地接收裸露的光纤的端部段。 质量可以最初形成为第一形状，然后可以膨胀并收缩到其第二形状。 它能够通过应用非机械刺激而恢复到其第一形状。

公开(公告)号：US4731078A

公开(公告)日：1988-03-15

申请号：US767808

申请日：1985-08-21

申请人： Vladimir A. Stoy ,  George P. Stoy

发明人： Vladimir A. Stoy ,  George P. Stoy

IPC分类号： A61F2/16 ,  A61L27/14 ,  G02B3/08

CPC分类号： A61F2/1648 ,  A61L27/14 ,  G02B3/08 ,  A61F2002/1683 ,  A61L2430/16

摘要： An artificial intraocular lens features an optical body for refracting images onto the retina and an outer surface that encloses the optical body, is exposed to fluid within the eye, and has a refractive index no greater than 1.40. In another aspect, the optical body includes an internal refractive surface whose contour can be selectively changed to change its refractive power.

摘要翻译： 人造眼内透镜具有用于将图像折射到视网膜上的光学体，并且包围光学体的外表面暴露于眼睛内的流体，并且具有不大于1.40的折射率。 在另一方面，光学体包括内部折射表面，其轮廓可以选择性地改变以改变其屈光力。