公开(公告)号：US20170348393A1

公开(公告)日：2017-12-07

申请号：US15524634

申请日：2015-11-05

Applicant: Yeda Research And Development Co., Ltd.

Inventor： Michal SCHWARTZ-EISENBACH ,  Ido AMIT ,  Merav COHEN ,  Orit MATCOVICH

IPC: A61K38/21

CPC classification number: A61K38/215 ,  A61K9/0085 ,  A61P25/28

Abstract: A method of upregulating an anti-inflammatory response in a central nervous system (CNS) of a subject in need thereof is disclosed. The method comprising locally administering to the CNS of the subject a therapeutically effective amount of IFN-beta, thereby upregulating the anti-inflammatory response in the CNS of the subject. Methods of treating an inflammation in a CNS or treating a disease, disorder, condition or injury of a CNS of a subject are also disclosed.

公开(公告)号：US20170037453A1

公开(公告)日：2017-02-09

申请号：US15303741

申请日：2015-04-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  David LARA - ASTIASO ,  Meital GURY

IPC: C12Q1/68 ,  G01N33/53

Abstract: A method of analyzing DNA which, in a cell, is bound to a DNA binding moiety, the method comprising: (a) obtaining at least two samples of complexes of DNA bound to a DNA binding moiety; (b) isolating the complexes on a solid support; (c) labeling the DNA of the complexes, wherein the labeling distinguishes between the complexes of the first of the at least two samples and the complexes of the second of the at least two samples; (d) pooling the at least two samples of complexes; and (e) isolating the complexes using an agent which specifically binds to the DNA binding moiety; and (f) analyzing the DNA of the complexes.

Abstract translation: 一种分析在细胞中与DNA结合部分结合的DNA的方法，所述方法包括：（a）获得至少两个与DNA结合部分结合的DNA的复合物样品; （b）在固体支持物上分离复合物; （c）标记复合物的DNA，其中所述标记区分所述至少两个样品中的第一个样品的复合物和所述至少两个样品中的第二个样品的复合物; （d）汇集至少两个复合物样品; 和（e）使用特异性结合DNA结合部分的试剂分离复合物; 和（f）分析复合物的DNA。

公开(公告)号：US20240376213A1

公开(公告)日：2024-11-14

申请号：US18692039

申请日：2022-09-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ido AMIT ,  Rony DAHAN ,  Yuval SHAPIR ,  Oren BARBOY

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K16/46

Abstract: A multispecific antibody is provided. The antibody comprises a first antigen binding moiety, which specifically binds to an immune checkpoint protein on intratumor T cells and a second antigen binding moiety which specifically binds to a conventional dendritic cell 1 (cDC1). Also provided are uses of such antibodies in cancer treatment.

公开(公告)号：US20230272484A1

公开(公告)日：2023-08-31

申请号：US18142618

申请日：2023-05-03

Applicant: Yeda Research and Development Co. Ltd. ,  Ichilov Tech Ltd.

Inventor： Ido AMIT ,  Assaf WEINER ,  Mor ZADA ,  Chamutal BORNSTEIN-OVITS ,  Shuang-Yin WANG ,  Yael COHEN

IPC: C12Q1/6886 ,  A61K38/07 ,  A61K31/69 ,  A61K38/13 ,  A61K31/7076 ,  A61P35/00

CPC classification number: C12Q1/6886 ,  A61K38/07 ,  A61K31/69 ,  A61K38/13 ,  A61K31/7076 ,  A61P35/00 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: A method of prognosing a subject diagnosed with multiple myeloma (MM) is provided. Also provided a method of treating a subject diagnosed with MM selected expressing intracellular PPIA and/or RRM2 above a predetermined threshold, the method comprising administering to the subject a therapeutically effective amount of at least one agent which specifically down-regulates activity or expression of PPIA and/or RRM2, thereby treating the subject.

公开(公告)号：US20200261577A1

公开(公告)日：2020-08-20

申请号：US16830461

申请日：2020-03-26

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Dalit TALMI-FRANK ,  Inna SOLOMONOV ,  Ido AMIT

IPC: A61K39/395 ,  A61K45/06 ,  A61K31/351 ,  A61K31/196 ,  C07K16/40 ,  A61K31/215

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.

公开(公告)号：US20190194653A1

公开(公告)日：2019-06-27

申请号：US16330774

申请日：2017-09-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Diego JAITIN ,  David LARA-ASTIASO ,  Assaf WEINER ,  Ido YOFE

IPC: C12N15/11 ,  C12N15/10 ,  C12N9/22 ,  C12Q1/6883

CPC classification number: C12N15/11 ,  C12N9/22 ,  C12N15/102 ,  C12N15/1093 ,  C12N15/63 ,  C12N2310/20 ,  C12N2800/80 ,  C12Q1/6883

Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.