Methods of identifying longevity modulators and therapeutic methods of use thereof
    11.
    发明申请
    Methods of identifying longevity modulators and therapeutic methods of use thereof 有权
    识别寿命调节剂的方法及其使用的治疗方法

    公开(公告)号:US20060272039A1

    公开(公告)日:2006-11-30

    申请号:US11372469

    申请日:2006-03-08

    IPC分类号: A01K67/033 C12Q1/48 A61K38/54

    CPC分类号: G01N33/573

    摘要: The present invention is based at least in part on the discovery of a role for the JNK signaling pathway in longevity. In particular, the present inventors have shown that overexpression of c-jun N-terminal kinase 1 (jnk-1) extends lifespan and that said extended lifespan is associated with DAF-16 phosphorylation by JNK-1 and the consequent DAF-16 localization to the nucleus. Accordingly, the present invention features methods of identifying modulators of longevity in assays featuring organisms and/or cells having a JNK signaling pathway and, optionally, an IR signaling pathway. Also featured is an in vitro method of identifying an agent capable of enhancing longevity featuring an assay composition having a JNK signaling pathway molecule and insulin signaling pathway molecule. Further featured are therapeutic methods for the use of JNK signaling pathway modulators to enhance longevity, to prevent or reduce obesity and to prevent or treat type II diabetes.

    摘要翻译: 本发明至少部分地基于JNK信号通路在长寿中的作用的发现。 特别地,本发明人已经表明,c-jun N-末端激酶1(jnk-1)的过表达延长了寿命,并且所述延长的寿命与JNK-1的DAF-16磷酸化和随后的DAF-16定位相关 核心 因此,本发明的特征在于鉴定具有JNK信号传导途径和任选的IR信号传导途径的生物体和/或细胞的测定中鉴定寿命调节剂的方法。 还特征在于鉴定能够增强寿命特性的具有JNK信号传导途径分子和胰岛素信号通路分子的测定组合物的试剂的体外方法。 进一步的特征是使用JNK信号通路调节剂来增强寿命,预防或减少肥胖和预防或治疗II型糖尿病的治疗方法。

    Ex-vessel core melt retention device preventing molten core concrete interaction

    公开(公告)号:US20060269035A1

    公开(公告)日:2006-11-30

    申请号:US11392652

    申请日:2006-03-30

    IPC分类号: G21C9/00

    CPC分类号: G21C9/016 Y02E30/40

    摘要: The present invention relates to a safety design and risk management of a reactor of a nuclear plant, and more particularly, to an ex-vessel core melt device preventing molten core concrete interaction, which is to handle very severe accidents caused by cooling-function loss to nuclear fuel. Due to the large quantity of nuclear fuel existing in the reactor and decay heat which is latent and continuously generated within the fuel mass for a long time after the nuclear chain reaction, the nuclear fuel is melted in gross at temperature up to 2,500 degrees centigrade, and thereby the surrounding structures and a reactor vessel are attacked and damaged, and in the end, a containment building floor is eroded. This situation may cause environmental radioactivity either by ultimate penetration of the cavity floor or by the buildup of non-condensable gas pressure (i.e., pressurizing the containment building structure), unless the reaction is arrested. The ex-vessel core melt retention device preventing molten core concrete interaction, which is installed for alleviating risks due to unexpected accidents over accidents considered as a design criteria of a nuclear plant, includes: horizontal jacket pipes located on a shell boundary of a cavity floor, the horizontal jacket pipes having water inlets A formed at their lower half in an appropriate density for allowing water to enter the bottom of the pipes; vertical pipes connected at both ends of the horizontal jacket pipes in the form of a dovetail to communicate with each other; and a water supply part located at the lower portion of the horizontal jacket pipes for allowing water to enter from the whole area of the bottom.

    Ice supplying device of refrigerator
    14.
    发明申请
    Ice supplying device of refrigerator 有权
    冰箱供冰装置

    公开(公告)号:US20050061017A1

    公开(公告)日:2005-03-24

    申请号:US10799732

    申请日:2004-03-15

    摘要: An ice supplying device of a refrigerator is disclosed, which has a structure a container is easily mounted in a door, or separated from the door. The ice supplying device includes an icemaker for making ice with a cool air of a freezer; a container mounted in a door in perpendicular to the inside of the door, the door for opening or closing the freezer, and provided below the icemaker for storing the ice when the door is closed; a dispenser provided on an outer surface of the door; and an ice chute provided in the door so as to connect the container and the dispenser with each other.

    摘要翻译: 公开了一种冰箱的供冰装置,其具有容易安装在门中或与门分离的结构。 制冰装置包括制冰机,用于用冷冻器的冷空气制冰; 安装在门内的容器,垂直于门的内部,用于打开或关闭冷冻室的门,并且设置在制冰机下方,用于当门关闭时存储冰; 设置在门的外表面上的分配器; 以及设置在门中的冰槽,以将容器和分配器彼此连接。

    Joint member manufactured using pipe and manufacturing method of the same
    15.
    发明申请
    Joint member manufactured using pipe and manufacturing method of the same 审中-公开
    使用管材制造的接头构件及其制造方法

    公开(公告)号:US20120256412A1

    公开(公告)日:2012-10-11

    申请号:US13064694

    申请日:2011-04-08

    申请人: Seung Oh

    发明人: Seung Oh

    IPC分类号: F16L41/00 B23P17/00

    摘要: Disclosed therein is a joint member, which includes a retaining portion formed by pressing a stainless steel pipe that is cut into a predetermined length, a joining portion having a spiral portion or a spiral groove, and an insert member made of synthetic resin and being pressed into the pipe so that a packing and a compression ring can be located in a proper position. The joint member using a pipe includes: a metal member having a retaining portion formed by pressing a stainless steel pipe cut into a predetermined length and a joining portion formed on the stainless steel pipe; and an insert member made of synthetic resin, the insert member being pressed to the retaining portion and mounted on the inner circumference of the metal member to locate joint means in a proper position.

    摘要翻译: 其中公开了一种接头构件,其包括通过按压被切割成预定长度的不锈钢管形成的保持部分,具有螺旋部分或螺旋槽的接合部分和由合成树脂制成并被按压的插入构件 进入管道,使得包装和压缩环可以位于适当的位置。 使用管的接头构件包括:金属构件,具有通过挤压切割成预定长度的不锈钢管形成的保持部和形成在不锈钢管上的接合部; 以及由合成树脂制成的插入构件,所述插入构件被按压到所述保持部并且安装在所述金属构件的内周上,以将接合装置定位在适当位置。

    Frequency conversion circuit
    16.
    发明申请
    Frequency conversion circuit 有权
    变频电路

    公开(公告)号:US20080051055A1

    公开(公告)日:2008-02-28

    申请号:US11878145

    申请日:2007-07-20

    申请人: Hyeon Hwang Seung Oh

    发明人: Hyeon Hwang Seung Oh

    IPC分类号: H04B1/26

    摘要: A frequency conversion circuit comprises an input stage composed of one or more transistors, the input stage outputting a current corresponding to a voltage-type RF signal which is input to the gate of the transistor; a frequency conversion stage receiving an LO signal, causing the output RF signal to transit by the frequency of the LO signal so as to output an IF signal, and detecting an output voltage of the IF signal; a bleeding transistor connected to the input stage, supplying a current corresponding to a DC voltage, applied to a gate-source stage thereof, as a bleeding current to the transistor of the input stage, and in an AC manner, operating complementarily with the input stage to control a current flowing in the frequency conversion stage; a common mode feedback circuit comparing an output voltage provided from the frequency conversion stage with a preset reference voltage, adjusting the output voltage such that the output voltage is equalized to the reference voltage, and directly feeding the adjusted output voltage to the bleeding transistor; and a load stage composed of resistors and distributing a power supply voltage to apply to the frequency conversion stage.

    摘要翻译: 频率转换电路包括由一个或多个晶体管组成的输入级,输入级输出对应于输入到晶体管的栅极的电压型RF信号的电流; 频率转换级接收LO信号,使得输出RF信号通过LO信号的频率转移,以输出IF信号,并检测IF信号的输出电压; 连接到输入级的出血晶体管,将施加到其栅极 - 源极级的对应于直流电压的电流作为输出级的晶体管的输出电流提供,并以AC方式与输入端互补地工作 控制在变频阶段流动的电流; 将从变频级提供的输出电压与预设参考电压进行比较的共模反馈电路,调整输出电压使得输出电压与参考电压相等,并将调整的输出电压直接馈送到出血晶体管; 以及由电阻器组成的负载级,并分配施加到变频级的电源电压。

    Method of generating a prosodic model for adjusting speech style and apparatus and method of synthesizing conversational speech using the same
    18.
    发明申请
    Method of generating a prosodic model for adjusting speech style and apparatus and method of synthesizing conversational speech using the same 失效
    生成用于调整语音风格的韵律模型的方法和使用其的合成对话语音的装置和方法

    公开(公告)号:US20070106514A1

    公开(公告)日:2007-05-10

    申请号:US11593852

    申请日:2006-11-07

    IPC分类号: G10L13/08

    CPC分类号: G10L13/033 G10L13/04

    摘要: An apparatus and method for adjusting the friendliness of a synthesized speech and thus generating synthesized speech of various styles in a speech synthesis system are provided. The method includes the steps of defining at least two friendliness levels; storing recorded speech data of sentences, the sentences being made up according to each of the friendliness levels; extracting at least one of prosodic characteristics for each of the friendliness levels from the recorded speech data, said prosodic characteristics including at least one of a sentence-final intonation type, boundary intonation types of intonation phrases in the sentence, and an average value of F0 of the sentence, with respect to the recorded speech data; and generating a prosodic model for each of the friendliness levels by statistically modeling the at least one of the prosodic characteristics.

    摘要翻译: 提供了一种用于调整合成语音的友好性并因此在语音合成系统中生成各种风格的合成语音的装置和方法。 该方法包括以下步骤:定义至少两个友好级别; 存储句子的记录语音数据,根据每个友好级别构成句子; 从记录的语音数据中提取每个友好级别的韵律特征中的至少一个,所述韵律特征包括句子最终语调类型,句子中的语调短语的边界语调类型和平均值F 相对于记录的语音数据,该句子的<0> 以及通过对所述韵律特征中的至少一个进行统计学建模来为每个友善度级别生成韵律模型。

    Refrigerator for health care
    19.
    发明申请
    Refrigerator for health care 审中-公开
    卫生保健冰箱

    公开(公告)号:US20060224050A1

    公开(公告)日:2006-10-05

    申请号:US11391697

    申请日:2006-03-29

    申请人: Ik Lee Seung Oh

    发明人: Ik Lee Seung Oh

    IPC分类号: A61B5/00 A61B5/02

    摘要: A refrigerator for health care is disclosed. A refrigerator for health care comprising a display device for displaying user health data; and a controller for receiving user health data from outside and supplying the user health data to the display device. The refrigerator according to the present invention has an effect that the user can take care of his/her health more efficiently.

    摘要翻译: 公开了用于保健的冰箱。 一种用于保健的冰箱,包括用于显示用户健康数据的显示装置; 以及用于从外部接收用户健康数据并将用户健康数据提供给显示装置的控制器。 根据本发明的冰箱具有使用者更有效地照顾他/她的健康的效果。

    Adhesive sheet for brazing magnesium alloy and method for brazing magnesium and aluminum alloy
    20.
    发明申请
    Adhesive sheet for brazing magnesium alloy and method for brazing magnesium and aluminum alloy 审中-公开
    用于钎焊镁合金的粘合片和钎焊镁和铝合金的方法

    公开(公告)号:US20060199019A1

    公开(公告)日:2006-09-07

    申请号:US11356847

    申请日:2006-02-17

    申请人: Seung Oh Beom Kim

    发明人: Seung Oh Beom Kim

    IPC分类号: B32B13/04

    摘要: An adhesive sheet for binding basic materials including an adhesive material layer with binding layer laminated on both sides, with the binding layer having a thickness of 6 to 20% of the thickness of the adhesive material layer. The binding layer contains a mixture of 20 to 70 weight % of a binder and 30 to 80 weight % of a mixed powder, where the mixed powder includes 60 to 66 weight % of flux powder, 30 to 33 weight % of aluminum and silicon alloy powder, and 1 to 10 weight % of cesium powder or lithium powder. The adhesive material layer is a mixture of 86 to 94 weight % of aluminum and 6 to 14 weight % of silicon. A brazing method for binding basic materials composed of aluminum alloy containing 0.2˜2.5% of magnesium in aluminum prepares an adhesive sheet as described, binds the adhesive sheet at a binding point between the basic materials, and brazes the basic material to which the adhesive sheet is bound.

    摘要翻译: 一种用于粘合基材的粘合片,其包括粘合剂层,其粘合层层压在两侧,粘结层的厚度为粘合材料层厚度的6至20%。 粘合层含有20〜70重量%的粘合剂和30〜80重量%的混合粉末的混合物,其中混合粉末包含60至66重量%的助熔剂粉末,30至33重量%的铝和硅合金 粉末和1〜10重量%的铯粉末或锂粉末。 粘合剂材料层是86至94重量%的铝和6至14重量%的硅的混合物。 用于在铝中含有0.2〜2.5%镁的铝合金的基材的钎焊方法制备如上所述的粘合片,将粘合片在基材之间的粘合点粘合,并将粘合片的基材 被束缚