摘要:
The present invention is based at least in part on the discovery of a role for the JNK signaling pathway in longevity. In particular, the present inventors have shown that overexpression of c-jun N-terminal kinase 1 (jnk-1) extends lifespan and that said extended lifespan is associated with DAF-16 phosphorylation by JNK-1 and the consequent DAF-16 localization to the nucleus. Accordingly, the present invention features methods of identifying modulators of longevity in assays featuring organisms and/or cells having a JNK signaling pathway and, optionally, an IR signaling pathway. Also featured is an in vitro method of identifying an agent capable of enhancing longevity featuring an assay composition having a JNK signaling pathway molecule and insulin signaling pathway molecule. Further featured are therapeutic methods for the use of JNK signaling pathway modulators to enhance longevity, to prevent or reduce obesity and to prevent or treat type II diabetes.
摘要:
The present invention relates to a safety design and risk management of a reactor of a nuclear plant, and more particularly, to an ex-vessel core melt device preventing molten core concrete interaction, which is to handle very severe accidents caused by cooling-function loss to nuclear fuel. Due to the large quantity of nuclear fuel existing in the reactor and decay heat which is latent and continuously generated within the fuel mass for a long time after the nuclear chain reaction, the nuclear fuel is melted in gross at temperature up to 2,500 degrees centigrade, and thereby the surrounding structures and a reactor vessel are attacked and damaged, and in the end, a containment building floor is eroded. This situation may cause environmental radioactivity either by ultimate penetration of the cavity floor or by the buildup of non-condensable gas pressure (i.e., pressurizing the containment building structure), unless the reaction is arrested. The ex-vessel core melt retention device preventing molten core concrete interaction, which is installed for alleviating risks due to unexpected accidents over accidents considered as a design criteria of a nuclear plant, includes: horizontal jacket pipes located on a shell boundary of a cavity floor, the horizontal jacket pipes having water inlets A formed at their lower half in an appropriate density for allowing water to enter the bottom of the pipes; vertical pipes connected at both ends of the horizontal jacket pipes in the form of a dovetail to communicate with each other; and a water supply part located at the lower portion of the horizontal jacket pipes for allowing water to enter from the whole area of the bottom.
摘要:
Provided is a refrigerator including an adiabatic space formed on an inner surface of a chilling chamber door and an ice machine disposed inside the adiabatic space, thereby enabling a more efficient usage of an inner space of the refrigerator. Also, the present invention provides a cooling air passage structure of a refrigerator for properly supplying cooling air for freezing to an inside of the refrigerator having an ice machine disposed on an inner surface of a chilling chamber door.
摘要:
An ice supplying device of a refrigerator is disclosed, which has a structure a container is easily mounted in a door, or separated from the door. The ice supplying device includes an icemaker for making ice with a cool air of a freezer; a container mounted in a door in perpendicular to the inside of the door, the door for opening or closing the freezer, and provided below the icemaker for storing the ice when the door is closed; a dispenser provided on an outer surface of the door; and an ice chute provided in the door so as to connect the container and the dispenser with each other.
摘要:
Disclosed therein is a joint member, which includes a retaining portion formed by pressing a stainless steel pipe that is cut into a predetermined length, a joining portion having a spiral portion or a spiral groove, and an insert member made of synthetic resin and being pressed into the pipe so that a packing and a compression ring can be located in a proper position. The joint member using a pipe includes: a metal member having a retaining portion formed by pressing a stainless steel pipe cut into a predetermined length and a joining portion formed on the stainless steel pipe; and an insert member made of synthetic resin, the insert member being pressed to the retaining portion and mounted on the inner circumference of the metal member to locate joint means in a proper position.
摘要:
A frequency conversion circuit comprises an input stage composed of one or more transistors, the input stage outputting a current corresponding to a voltage-type RF signal which is input to the gate of the transistor; a frequency conversion stage receiving an LO signal, causing the output RF signal to transit by the frequency of the LO signal so as to output an IF signal, and detecting an output voltage of the IF signal; a bleeding transistor connected to the input stage, supplying a current corresponding to a DC voltage, applied to a gate-source stage thereof, as a bleeding current to the transistor of the input stage, and in an AC manner, operating complementarily with the input stage to control a current flowing in the frequency conversion stage; a common mode feedback circuit comparing an output voltage provided from the frequency conversion stage with a preset reference voltage, adjusting the output voltage such that the output voltage is equalized to the reference voltage, and directly feeding the adjusted output voltage to the bleeding transistor; and a load stage composed of resistors and distributing a power supply voltage to apply to the frequency conversion stage.
摘要:
A method of fabricating a flexible mold for forming a flat display panel, comprising: forming a plurality of protrusions on a flexible film, forming plated patterns between the protrusions on the flexible film, the plated patterns having an inverted shape corresponding to partitions that define one or more sub-pixel regions in the panel, and removing the protrusions to form a flexible material.
摘要:
An apparatus and method for adjusting the friendliness of a synthesized speech and thus generating synthesized speech of various styles in a speech synthesis system are provided. The method includes the steps of defining at least two friendliness levels; storing recorded speech data of sentences, the sentences being made up according to each of the friendliness levels; extracting at least one of prosodic characteristics for each of the friendliness levels from the recorded speech data, said prosodic characteristics including at least one of a sentence-final intonation type, boundary intonation types of intonation phrases in the sentence, and an average value of F0 of the sentence, with respect to the recorded speech data; and generating a prosodic model for each of the friendliness levels by statistically modeling the at least one of the prosodic characteristics.
摘要:
A refrigerator for health care is disclosed. A refrigerator for health care comprising a display device for displaying user health data; and a controller for receiving user health data from outside and supplying the user health data to the display device. The refrigerator according to the present invention has an effect that the user can take care of his/her health more efficiently.
摘要:
An adhesive sheet for binding basic materials including an adhesive material layer with binding layer laminated on both sides, with the binding layer having a thickness of 6 to 20% of the thickness of the adhesive material layer. The binding layer contains a mixture of 20 to 70 weight % of a binder and 30 to 80 weight % of a mixed powder, where the mixed powder includes 60 to 66 weight % of flux powder, 30 to 33 weight % of aluminum and silicon alloy powder, and 1 to 10 weight % of cesium powder or lithium powder. The adhesive material layer is a mixture of 86 to 94 weight % of aluminum and 6 to 14 weight % of silicon. A brazing method for binding basic materials composed of aluminum alloy containing 0.2˜2.5% of magnesium in aluminum prepares an adhesive sheet as described, binds the adhesive sheet at a binding point between the basic materials, and brazes the basic material to which the adhesive sheet is bound.