Abstract:
Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)o.2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl.
Abstract:
Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)o.2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl.
Abstract:
Disclosed herein is an oil separator for air conditioners that is capable of separating oil from refrigerant. The oil separator comprises a shell having a cylindrical space defined therein, a refrigerant introduction pipe for introducing refrigerant into the shell, a refrigerant discharge pipe for discharging the refrigerant out of the shell, and oil-drop growth accelerating member for accelerating growth of oil drops contained in the refrigerant flowing in the shell.
Abstract:
Disclosed is an air conditioner. The air conditioner a main compressor for compressing a refrigerant; a four-way valve disposed at a discharge side of the main compressor and switching a fluid path; an outdoor heat exchanger having one side connected with the four-way valve; an indoor heat exchanger having one side connected with the outdoor heat exchanger and the other side connected with the four-way valve; an expansion valve disposed between the outdoor heat exchanger and the indoor heat exchanger; and an auxiliary compression unit for reducing the load on the main compressor. Accordingly, since the load on the main compressor decreases, efficiency and reliability of the main compressor are enhanced and noises are reduced. In addition, an instrumental part such as a bearing inside the main compressor is not subject to abrasion and high heat damage to a motor unit is prevented.
Abstract:
The present invention discloses an abutment of a dental implant consisting of an abutment screw and a shoulder surface. The upper structure of a crown or bridge abutment, i.e., the abutment screw is made of titanium alloy, and surface-treated in brown color by an anodizing process, and the connecting structure thereof, i.e., the shoulder surface is made of ceramic material containing zirconia of a white color, thereby providing an adequate mechanical strength, while maintaining the natural color of human teeth and light permeability. Further, the present invention discloses a method of aesthetically surface-treating the abutment screw of a dental implant abutment by using the anodizing process, and a method of fabricating the shoulder surface of a dental implant abutment.
Abstract:
A system for controlling an air conditioner includes a plurality of outdoor units each having at least one compressor and an outdoor heat exchanger, an indoor unit connected to the outdoor units by a refrigerant tube, the indoor unit having an indoor heat exchanger, and a pressure regulating tube for equalizing pressure according to an operation mode. The pressure regulating tube is connected between the outdoor units.
Abstract:
2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula (I) and methods of using same in the treatment of cancer, in particular, solid cancers and leukemia are provided. Pharmaceutical compositions comprising the compounds are also provided.
Abstract:
An image forming apparatus and a method to control the same. The image forming apparatus determines whether the object to be printed is real money. If the object is real money, the image forming apparatus prints a variety of counterfeit money discrimination information (e.g., the counterfeit money preventing pattern, the warning message, or the unique number of the image forming apparatus used for printing the money) on the back side of the copy of the money, and prints the original image of the money on the front side of the copy of the money without any change. Therefore, the image forming apparatus can color-print the original image of the money without any change, and can prevent the copied money from being used as counterfeit money.
Abstract:
The present invention provides therapeutically effective 2,4,5-trisubstituted imidazole compounds, methods of preparing the same, and compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-microbial agents. The anti-microbial properties of the compounds include anti-bacterial and/or anti-fungal activity.
Abstract:
An image forming apparatus, a bogus note managing system including the same, and a bogus note managing method that are capable of accurately and efficiently managing a bogus note such that the bogus note cannot be used for a bad purpose, the image forming apparatus including: a read unit to determine whether an object to be read is money; a storage unit to store money registration information including identification information of the money; a comparison unit to compare money identification information, which is received so as to identify the money, with the identification information stored in the storage unit when the object to be read is the money; and a control unit to control history information of the money to be stored in the storage unit when the money identification information is identical to the identification information.