公开(公告)号：US20080306284A1

公开(公告)日：2008-12-11

申请号：US11631486

申请日：2005-07-05

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

IPC分类号： C07D493/18 ,  C07D407/10

CPC分类号： A61K36/82 ,  A23F3/163 ,  A23L2/52 ,  A23L33/105 ,  A61K31/353 ,  C07D311/62

摘要： The present invention provides lipase inhibitors containing dimers having an epigallocatechin gallate (EGCG) unit derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of proanthocyanidins represented by the formula: wherein R1 and R2 independently represent H or OH, and R3 and R4 independently represent H or a galloyl group; as well as foods and beverages and pharmaceutical compositions containing said lipase inhibitors.

摘要翻译： 本发明提供含有来自茶叶的表没食子儿茶素没食子酸酯（EGCG）单元的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。 更具体地说，本发明提供含有至少一种由下式表示的原花色素的脂肪酶抑制剂：其中R1和R2独立地表示H或OH，R3和R4独立地表示H或加成酯基; 以及含有所述脂肪酶抑制剂的食品和饮料和药物组合物。

公开(公告)号：US20080317821A1

公开(公告)日：2008-12-25

申请号：US11631507

申请日：2005-07-05

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

IPC分类号： A61K31/353 ,  A61P1/00

CPC分类号： A61K36/82 ,  A23F3/163 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A23V2200/332 ,  A23V2250/21 ,  A23V2250/214

摘要： The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula: wherein G represents a galloyl group; theasinensins represented by the formula: wherein R1 represents G or H, and R2 represents G; and theaflavins represented by the formula:

摘要翻译： 本发明提供含有衍生自茶的黄烷-3-醇的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。 更具体地，本发明提供了含有下式表示的至少一种ass胺的脂肪酶抑制剂：其中，G表示加成酰基; 由下式表示的亚敏素：其中R1表示G或H，R2表示G; 和由以下公式表示的茶黄素：

公开(公告)号：US20080207747A1

公开(公告)日：2008-08-28

申请号：US11631506

申请日：2005-07-05

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

IPC分类号： C07D311/04 ,  C07D493/12 ,  A61K31/365 ,  A61K31/352 ,  A61P3/06

CPC分类号： A61K36/82 ,  A23F3/163 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K31/353 ,  C07D311/62 ,  C07D493/14 ,  A23V2250/21 ,  A23V2250/214 ,  A23V2200/332 ,  A23V2200/326

摘要： The present invention provides lipase inhibitors containing flavan-3-ol monomers or acylates thereof derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of flavan-3-ol monomers represented by the formula: wherein R1 and R3 independently represent H or OH, R2 represents H, R4 represents H, G, 3MeG or p-cou, R5 represents H or G, R4′ and R5′ independently represent H or G, R4″ represents H or G, and G, 3MeG and p-cou respectively represent the groups of the formulae: or acylates thereof; as well as foods and beverages and medicines containing said lipase inhibitors.

摘要翻译： 本发明提供了含有衍生自茶的黄烷-3-醇单体或其酰化物以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。 更具体地，本发明提供了含有下式所示的黄烷-3-醇单体中的至少一种的脂肪酶抑制剂：其中R 1和R 3独立地表示H或OH R 2代表H，R 4代表H，G，3MeG或对 - 可可，R 5代表H或G，R _{4 <＆gt;和R 5'独立地表示H或G，R 4'表示H或G，并且G，3MeG和p-cou分别表示 下式的基团：或其酰化物; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。}

公开(公告)号：US20070254948A1

公开(公告)日：2007-11-01

申请号：US11660784

申请日：2005-08-22

申请人： Yuko Fukui ,  Masaaki Nakai ,  Sumio Asami

发明人： Yuko Fukui ,  Masaaki Nakai ,  Sumio Asami

IPC分类号： A61K31/351 ,  A23L2/00 ,  A61P3/00 ,  C07D309/10

CPC分类号： A61K31/7024 ,  A23F3/16 ,  A23F3/18 ,  A23F3/34 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/214 ,  A23V2250/21 ,  A23V2200/02 ,  A23V2200/30

摘要： The present invention provides lipase inhibitory agents comprising a gallotannin or ellagitannin component(s) isolated from teas or Tellima grandiflora as well as foods and beverages and medicines containing said inhibitory agents. The present invention provides lipase inhibitory agents comprising at least one of compounds represented by formula I below: wherein R1, R2 and R3 independently represent H or a gallic acid residue, and R4 and R5 represent H or a gallic acid residue, or R4 and R5 together form an HHDP group represented by the formula below: provided that at least two of R1 to R5 represent a gallic acid residue or when all of R1, R2 and R3 are H, R4 and R5 together form the HHDP group; as well as foods and beverages and medicines containing said lipase inhibitory agents.

摘要翻译： 本发明提供脂肪酶抑制剂，其包含从茶或Tellima grandiflora分离的鞣酸单宁或鞣花素组分，以及含有所述抑制剂的食品和饮料和药物。 本发明提供脂肪酶抑制剂，其包含至少一种由下式I表示的化合物：其中R 1，R 2和R 3独立地为 表示H或没食子酸的残基，R 4和R 5表示H或没食子酸残基，或R 4和R 3 > 5＆gt;一起形成由下式表示的HHDP基团：条件是R 1至R 5中的至少两个表示没食子酸残基或全部 R 1，R 2和R 3均为H，R 4和R 5， 共同组成HHDP组; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

公开(公告)号：US08309745B2

公开(公告)日：2012-11-13

申请号：US12872872

申请日：2010-08-31

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

IPC分类号： C07D311/62

CPC分类号： C07D311/62 ,  A23L33/105

摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.

摘要翻译： 本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食衍生的脂肪的吸收和/或有助于抑制和预防肥胖症，以及具有 掺入其中的这种脂肪酶活性抑制剂。 本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且当其中掺入时不会损害食品或饮料的风味。 本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。 本发明的另一个目的是提供抗氧化剂。 为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄）或三聚体掺入食品或饮料中。 结果，可以抑制膳食来源的脂肪的吸收，并且还可以获得抗氧化作用。 本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

公开(公告)号：US20080275258A1

公开(公告)日：2008-11-06

申请号：US11597291

申请日：2005-05-26

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

IPC分类号： C07D311/04

CPC分类号： C07D311/62 ,  A23L33/105

摘要： It is intended to provide a lipase activity inhibitor which shows a high inhibitory activity on pancreatic lipase, regulates the absorption of fat from meals and/or contributes to the regulation or prevention of obesity, a food and a drink containing the same, and a tea-origin lipase inhibitor being highly preferable and not worsening taste. It is also intended to provide a method of producing the lipase inhibitor. It is further intended to provide antioxidative agent. To overcome these problems, an epigallocatechin dimer (oolong homo bis flavans) or trimer is added to foods or drinks. Thus, the absorption of fat from meals can be regulated and an antioxidative effect can be obtained. The above compounds can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.

摘要翻译： 旨在提供对胰脂肪酶具有高抑制活性的脂肪酶活性抑制剂，调节从膳食中吸收脂肪和/或有助于调节或预防肥胖症的食物和饮料，以及茶 - 原料脂肪酶抑制剂是非常优选的，而不是恶化味道。 还旨在提供一种生产脂肪酶抑制剂的方法。 还旨在提供抗氧化剂。 为了克服这些问题，向食物或饮料中加入表没食子儿茶素二聚体（乌龙同双双黄烷）或三聚体。 因此，可以调节从膳食中吸收脂肪，并且可以获得抗氧化作用。 上述化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

公开(公告)号：US20110219476A1

公开(公告)日：2011-09-08

申请号：US13062093

申请日：2008-09-04

申请人： Eiichiro Ono ,  Yuko Fukui

发明人： Eiichiro Ono ,  Yuko Fukui

IPC分类号： A01H5/00 ,  C12N15/63 ,  C12N5/10 ,  C12N1/00 ,  C12P19/44 ,  C07H21/04 ,  C12N9/10

CPC分类号： C12N15/825 ,  C12N9/1051

摘要： The present invention provides a novel glucuronosyltransferase, a polynucleotide encoding the same (e.g., a polynucleotide comprising a polynucleotide consisting of the nucleotide sequence at positions 1 to 1362 in the nucleotide sequence represented by SEQ ID NO: 7, or a polynucleotide comprising a polynucleotide encoding a protein having the amino acid sequence represented by SEQ ID NO: 8); and so on. A novel glucuronosyltransferase having a broad substrate specificity and others can thus be provided.

摘要翻译： 本发明提供了一种新的葡糖醛酸基转移酶，其编码该多核苷酸的多核苷酸（例如，包含由SEQ ID NO：7表示的核苷酸序列中的第1至1362位的核苷酸序列组成的多核苷酸的多核苷酸，或包含编码 具有SEQ ID NO：8所示的氨基酸序列的蛋白质）; 等等。 因此可以提供具有广泛底物特异性的其它新颖的葡糖醛酸基转移酶等。

公开(公告)号：US20110172300A1

公开(公告)日：2011-07-14

申请号：US13061038

申请日：2009-08-28

申请人： Yuko Fukui ,  Takashi Iwashita

发明人： Yuko Fukui ,  Takashi Iwashita

IPC分类号： A61K31/353 ,  C07D407/12 ,  C07D407/14 ,  A61P3/10

CPC分类号： C07D311/62 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  C12N9/2408 ,  C12Y302/0102 ,  A23V2250/214 ,  A23V2200/328

摘要： The present invention provides an α-glucosidase inhibitor containing a novel epigallocatechin gallate trimer and an epigallocatechin gallate polymer. Decomposition of starch derived from a meal and sugar derived from a polysaccharide can be suppressed by α-glucosidase inhibitory action, thus suppressing absorption. A food and drink excellent in α-glucosidase inhibitory action for suppressing sugar absorption and further for preventing diabetes for a long time can be provided by adding the α-glucosidase inhibitor to a food and drink.

摘要翻译： 本发明提供一种含有新型表没食子儿茶素没食子酸酯三聚体和表没食子儿茶素没食子酸酯聚合物的α-葡糖苷酶抑制剂。 可以通过α-葡萄糖苷酶抑制作用抑制来自膳食的淀粉和多糖衍生的淀粉的分解，抑制吸收。 通过向食品和饮料中加入α-葡糖苷酶抑制剂，可以提供一种在抑制糖吸收和进一步预防糖尿病长时间的α-葡糖苷酶抑制作用方面优异的食品和饮料。

公开(公告)号：US20110152361A1

公开(公告)日：2011-06-23

申请号：US13060996

申请日：2009-08-28

申请人： Yuko Fukui ,  Mai Imamoto

发明人： Yuko Fukui ,  Mai Imamoto

IPC分类号： A61K31/353 ,  C07D311/74 ,  A61P29/00 ,  A61P9/00

CPC分类号： A61K31/353 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  C07D311/62 ,  A23V2250/214 ,  A23V2200/326

摘要： Providing a compound capable of continuously taking and having a vascular endothelial function improving effect by enhancing NO function from the vascular endothelial cells.A compound represented by Formula (I) wherein R1, R2, R3 and R4 are each independently H or a gallate group, a vascular endothelial function improving agent, food and drink or pharmaceutical composition containing the compound.

摘要翻译： 通过增加血管内皮细胞的NO功能，提供能够连续摄取和具有血管内皮功能改善作用的化合物。 式（I）表示的化合物，其中R 1，R 2，R 3和R 4各自独立地为H或没食子酸酯基，血管内皮功能改善剂，食品和饮料或含有该化合物的药物组合物。

公开(公告)号：US20100113390A1

公开(公告)日：2010-05-06

申请号：US12524414

申请日：2007-01-26

申请人： Shigeaki Fujikawa ,  Yuko Fukui ,  Hiroshi Watanabe ,  Yuji Nonaka ,  Takeshi Yasumoto ,  Hideo Naoki

发明人： Shigeaki Fujikawa ,  Yuko Fukui ,  Hiroshi Watanabe ,  Yuji Nonaka ,  Takeshi Yasumoto ,  Hideo Naoki

IPC分类号： A61K31/715 ,  C07H3/04 ,  C07H3/06 ,  C07H5/10 ,  A61P3/04

CPC分类号： C07H11/00 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/60 ,  A61K2800/782 ,  A61Q5/02 ,  A61Q19/00 ,  C07H7/033 ,  C07H13/06 ,  A23V2200/326 ,  A23V2200/332 ,  A23V2250/50 ,  A23V2250/28

摘要： The present invention provides a fucoidan-derived low molecular weight compound with a good quality of taste, which has a specified structure and function and is free from problems in absorption, antigenicity, uniformity, an anticoagulant activity and so on, which problems arise when developing fucoidan, a sulfated polysaccharide having an extremely large molecular weight, as drugs or health foods. As a result of analyzing low molecular weight compounds obtained by acid hydrolysis of fucoidan, the inventors have identified fucoidan oligosaccharides (I) to (XI). Further, these oligosaccharides have been found to have anti-obesity and/or blood glucose elevation suppressing effects through inhibition of carbohydrate and/or lipid absorption as a result of α-glucosidase inhibition and/or lipase inhibition.

摘要翻译： 本发明提供具有优良品质的岩藻依聚糖衍生的低分子量化合物，其具有特定的结构和功能，并且不存在吸收，抗原性，均匀性，抗凝血活性等问题，当发展时出现问题 岩藻依聚糖，分子量极大的硫酸化多糖作为药物或保健食品。 通过分析由岩藻依聚糖酸水解获得的低分子量化合物的结果，本发明人鉴定了岩藻依聚糖寡糖（I）至（XI）。 此外，已经发现这些寡糖通过由于α-葡糖苷酶抑制和/或脂肪酶抑制而抑制碳水化合物和/或脂质吸收而具有抗肥胖和/或血糖升高抑制作用。