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11.发明授权公开(公告)号：US06355225B1
公开(公告)日：2002-03-12
申请号：US09412662
申请日：1999-10-05
申请人： John M. Alford , Lon J. Wilson
发明人： John M. Alford , Lon J. Wilson
IPC分类号： A61B5055
CPC分类号： B82Y15/00 , A61K49/189 , B82Y5/00 , Y10S977/734 , Y10S977/865 , Y10S977/881 , Y10S977/93 , Y10T436/24
摘要： A non-toxic contrast agent for enhancing contrast in in vivo magnetic resonance measurements, comprised of a water-soluble, stable paramagnetic fullerene that is free of paramagnetic metal species. A preferred contrast agent is a fullerol having at least one unpaired electron.
摘要翻译： 一种用于增强体内磁共振测量对比度的无毒造影剂，其由不含顺磁性金属物质的水溶性，稳定的顺磁性富勒烯组成。 优选的造影剂是具有至少一个不成对电子的富勒醇。
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12.发明授权Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging 失效顺磁金属卟啉作为磁共振成像的对比剂
公开(公告)号：US5262532A
公开(公告)日：1993-11-16
申请号：US733568
申请日：1991-07-22
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： Porphyrin-complex compounds useful as contrast agents in magnetic resonance imaging (MRI) having the formula ##STR1## where Y is a transition metal such as Fe.sup.III, Cr.sup.III, Mn.sup.III, Mn.sup.II and Cu.sup.II, X is a biologically well-tolerated metal complexing anion such as Cl.sup.-, CF.sub.3 SO.sub.3 or CF.sub.3 COO.sup.- and R is a nonionic water solubilizing moiety.
摘要翻译： 卟啉复合物可用作具有式（IMA）的磁共振成像（MRI）中的造影剂，其中Y是过渡金属如FeIII，CrIII，MnIII，MnII和CuII，X是生物良好耐受的金属络合阴离子 作为Cl - ，CF 3 SO 3或CF 3 COO-，R是非离子水溶性部分。
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公开(公告)号：US20120141543A1
公开(公告)日：2012-06-07
申请号：US11972886
申请日：2008-01-11
IPC分类号： A61K31/765 , A61P19/00 , A61K9/00 , B82Y5/00 , B82Y30/00
CPC分类号： B82Y40/00 , A61K9/0092 , A61K31/765 , B82Y30/00
摘要： Novel methods and compositions of nanocomposites are provided. One exemplary composition comprises a biocompatible polymer, such as polypropylene fumarate, and a carbon nanotube, such as a single walled carbon nanotube, an ultra-short carbon nanotube, or a substituted ultra-short carbon nanotube. An exemplary method comprises providing a biocompatible polymer and a carbon nanotube and combining a biocompatible polymer and a carbon nanotube to form a nanocomposite. Another exemplary method comprises providing a nanocomposite comprising a biocompatible polymer and a carbon nanotube and administering the composition to a subject.
摘要翻译： 提供了纳米复合材料的新方法和组成。 一种示例性组合物包括生物相容性聚合物，例如富马酸聚丙烯酯和碳纳米管，例如单壁碳纳米管，超短碳纳米管或取代的超短碳纳米管。 一种示例性方法包括提供生物相容性聚合物和碳纳米管，并结合生物相容性聚合物和碳纳米管以形成纳米复合材料。 另一个示例性方法包括提供包含生物相容性聚合物和碳纳米管的纳米复合材料，并将所述组合物施用于受试者。
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公开(公告)号：US20110274624A1
公开(公告)日：2011-11-10
申请号：US13084234
申请日：2011-04-11
申请人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
发明人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
CPC分类号： B82Y15/00 , A61K49/1818 , A61K49/1884
摘要： MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. The non-chelated contrast agents include T1 contrast agents, such as those including Gd(III) or Mn(II). Methods of MRI imaging and methods of making the compositions are also disclosed.
摘要翻译： 公开了在至少一个多孔微粒或纳米颗粒的孔中包含非螯合的MRI造影剂的MRI成像组合物。 发现本发明的组合物表现出增加的松弛度，因此增强MRI成像。 非螯合造影剂包括T1造影剂，例如包括Gd（III）或Mn（II）的造影剂。 还公开了MRI成像的方法和制备组合物的方法。
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公开(公告)号：US07758889B1
公开(公告)日：2010-07-20
申请号：US10623110
申请日：2003-07-18
申请人： Uri Sagman , Michael G. Rosenblum , Lon J. Wilson
发明人： Uri Sagman , Michael G. Rosenblum , Lon J. Wilson
CPC分类号： A61K31/337 , A61K47/6855 , A61K47/6865 , A61K2039/505 , C07K16/3053 , C07K2317/622
摘要： Herein we disclose a composition, comprising a Cn-Ab, wherein Cn is a fullerene or nanotube comprising n carbon atoms, and Ab is a moiety comprising an antigen-binding site and is linked to the Cn. The composition can further comprise a therapeutic molecule associated with the Cn-Ab. Also, we disclose a method of treating a disease in a mammal, comprising administering to the mammal an effective amount of the composition.
摘要翻译： 在本文中，我们公开了包含Cn-Ab的组合物，其中C n是包含n个碳原子的富勒烯或纳米管，Ab是包含抗原结合位点并与Cn连接的部分。 组合物还可以包含与Cn-Ab相关的治疗分子。 此外，我们公开了一种治疗哺乳动物疾病的方法，包括向哺乳动物施用有效量的组合物。
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公开(公告)号：US20090214101A1
公开(公告)日：2009-08-27
申请号：US12325849
申请日：2008-12-01
IPC分类号： G06K9/00 , C07K16/18 , G01N33/483
CPC分类号： A61K49/16 , A61K47/60 , A61K49/085
摘要： Compositions and methods related to targeted carbon nanostructures. More particularly, targeted carbon nanostructures comprising: a Cn, a cross-linker, and a targeting agent, wherein Cn refers to a fullerene moiety or nanotube comprising n carbon atoms. One example of a method may involve a method for imaging comprising: contacting a targeted carbon nanostructure and a cell; allowing the cell to internalize the carbon nanostructure; and detecting the presence of internalized carbon nanostructures.
摘要翻译： 与目标碳纳米结构相关的组成和方法。 更具体地，包括Cn，交联剂和靶向剂的靶向碳纳米结构，其中C n是指包含n个碳原子的富勒烯部分或纳米管。 方法的一个实例可以包括用于成像的方法，其包括：使目标碳纳米结构和细胞接触; 使细胞内化碳纳米结构; 并检测内在碳纳米结构的存在。
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公开(公告)号：US20090136987A1
公开(公告)日：2009-05-28
申请号：US12274174
申请日：2008-11-19
CPC分类号： A61K51/00 , A61K49/0409 , A61K49/0447 , B82Y5/00
摘要： Compositions and methods related to carbon Nanotubes are provided. More particularly, imaging agents comprising carbon Nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon Nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.
摘要翻译： 提供了与碳纳米管有关的组成和方法。 更具体地，提供了包含内部装载有造影剂的碳纳米管和相关方法的成像剂。 方法的一个实例可以包括用于成像的方法，其包括：提供包含负载有造影剂的碳纳米管的成像剂; 将成像剂引入细胞中; 并对细胞成像以检测成像剂的存在。
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公开(公告)号：US20060051290A1
公开(公告)日：2006-03-09
申请号：US11180088
申请日：2005-07-13
CPC分类号： B82Y30/00 , A61K49/1884 , A61K51/1251 , B82Y5/00 , Y10T428/2935
摘要： A method for delivering a radiotherapeutic agent to a target, comprises administering a composition comprising water-soluble nanotubes having an average length less than 50 nm and a radionuclide so as to expose the target to the composition. The nanotubes can be functionalized with a monoclonal antibody having an affinity for the target. The radionuclide can be contained in the nanotubes, which can be derivatized. The nanotubes can be loaded with I2 or 211AtI, another α-emitter, including but not limited to 211AtI, 225Ac, 212Bi, 213Bi, and combinations thereof. The nanotubes have an average length less than 40 nm, or an average length less than 30 nm.
摘要翻译： 将放射治疗剂递送至靶的方法包括施用包含平均长度小于50nm的水溶性纳米管和放射性核素的组合物，以将靶暴露于组合物。 纳米管可以用对靶具有亲和性的单克隆抗体进行功能化。 放射性核素可以包含在可以衍生的纳米管中。 纳米管可以加载另一个α发射体，其中包括但不限于二级，二级，二级，二级，二级， Bi，Bi，Bi，Bi，Bi及其组合。 纳米管的平均长度小于40nm，平均长度小于30nm。
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19.发明授权公开(公告)号：US06660248B2
公开(公告)日：2003-12-09
申请号：US10038075
申请日：2001-11-09
申请人： Lon J. Wilson , John T. Wharton , Uri Sagman
发明人： Lon J. Wilson , John T. Wharton , Uri Sagman
IPC分类号： A61K5100
CPC分类号： B82Y15/00 , A61K47/6949 , A61K49/0447 , B82Y5/00 , Y10S516/901 , Y10S977/835 , Y10S977/928
摘要： An contrast agent for therapeutic or diagnostic treatment comprises a fullerene scaffold and an iodinated moiety bonded to the scaffold. The agent may further comprise a water solubilizing moiety bonded to the scaffold, which may be a serinol malonodiamide, hydroxyl, and 1,3-diol. The fullerene scaffold may comprise an empty fullerene or an endohedral fullerene. A method for making the agent includes a) synthesizing iodinating moieties, b) protecting serinols, forming protected serinols, c) attaching the protected serinols to the iodinated moieties, forming iodinated serinols, d) attaching the iodinated serinols to the fullerene scaffold, and, optionally, d) de-protecting the serinols. Also disclosed are a method for providing diagnostic treatment to a patient comprising administering to said patient a radiopaque effective amount of a contrast agent comprising a fullerene scaffold and an iodinated moiety, a method of making a blood pool agent.
摘要翻译： 用于治疗或诊断治疗的造影剂包括富勒烯支架和结合到支架的碘化部分。 该试剂还可以包含结合到支架上的水溶性部分，其可以是丝氨醇壬二酰胺，羟基和1,3-二醇。 富勒烯支架可以包括空的富勒烯或内嵌的富勒烯。 制备该试剂的方法包括：a）合成碘化部分，b）保护丝氨醇，形成受保护的丝氨醇，c）将被保护的丝氨醇连接到碘化部分，形成碘化丝氨醇，d）将碘化丝氨醇连接到富勒烯支架上， 任选地，d）脱保护丝氨醇。 还公开了一种向患者提供诊断治疗的方法，包括向所述患者施用不透射线的有效量的包含富勒烯支架和碘化部分的造影剂，制备血液池剂的方法。
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