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    METHOD AND SYSTEM FOR CONTROL OF A PATIENT'S BODY TEMPERATURE BY WAY OF A TRASLUMINALLY INSERTABLE HEAT EXCHANGE CATHETER
    12.
    发明申请
    METHOD AND SYSTEM FOR CONTROL OF A PATIENT'S BODY TEMPERATURE BY WAY OF A TRASLUMINALLY INSERTABLE HEAT EXCHANGE CATHETER 审中-公开

    公开(公告)号：US20190083300A1

    公开(公告)日：2019-03-21

    申请号：US16124601

    申请日：2018-09-07

    Applicant: Zoll Circulation, Inc.

    Inventor： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    IPC: A61F7/00 ,  A61M25/10 ,  A61F7/12 ,  A61B17/00 ,  A61F7/10 ,  A61B17/22

    Abstract: Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

    DISPOSABLE CASSETTE FOR INTRAVASCULAR HEAT EXCHANGE CATHETER
    14.
    发明申请
    DISPOSABLE CASSETTE FOR INTRAVASCULAR HEAT EXCHANGE CATHETER 审中-公开
    用于血管热交换导管的可替代CASSETTE

    公开(公告)号：US20140364928A1

    公开(公告)日：2014-12-11

    申请号：US14337066

    申请日：2014-07-21

    Applicant: ZOLL CIRCULATION, INC.

    Inventor： Timothy R. Machold ,  Nicole Denise Bloom ,  Alex T. Roth ,  David J. Scott ,  Jose Alejandro ,  Edward A. Oliver

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/22051 ,  A61F7/0085 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M5/44 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/127

    Abstract: A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.

    Abstract translation: 用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。 舱壁包括储存段和泵段。 储存器部分设置有用于监测系统中的热交换流体的量的装置。 隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。 泵部分构造成允许在恒定压力下泵送热交换流体。

    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA
    15.
    发明申请
    INHIBITION OF PLATELET ACTIVATION, AGGREGATION AND/OR ADHESION BY HYPOTHERMIA 审中-公开
    抑制血小板活化，聚集和/或粘附

    公开(公告)号：US20130304166A1

    公开(公告)日：2013-11-14

    申请号：US13868764

    申请日：2013-04-23

    Applicant: ZOLL CIRCULATION INC.

    Inventor： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/126

    Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    Abstract translation: 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以将抗发抖药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5摄氏度）的患者。 如果确定不再期望血小板抑制，例如当患者即将进行其中出血可能成问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
    17.
    发明授权
    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
    通过低温抑制血小板活化，聚集和/或粘附

    公开(公告)号：US09358153B2

    公开(公告)日：2016-06-07

    申请号：US13868764

    申请日：2013-04-23

    Applicant: ZOLL Circulation Inc.

    Inventor： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

    IPC: A61F7/12

    CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/126

    Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    Abstract translation: 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以将抗发抖药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5摄氏度）的患者。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

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