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公开(公告)号：US20050288487A1
公开(公告)日：2005-12-29
申请号：US10500784
申请日：2003-01-03
申请人： Kang Li , Yucheng Li , Shen-Wu Wang , Guanghui Hu , Zhengbin Yao
发明人： Kang Li , Yucheng Li , Shen-Wu Wang , Guanghui Hu , Zhengbin Yao
IPC分类号： A01K67/027 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/04 , A61P7/06 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/02 , A61P29/00 , A61P31/12 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/00 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/569
CPC分类号： C07K16/28 , A01K2217/075 , A61K39/00 , A61K2039/505 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , G01N33/56972 , G01N2500/00
摘要： Mast cell-expressed membrane proteins that are highly expressed in human mast cells and the lungs as compared to brain, heart, kidney, liver, tracheal, and similar tissues. The proteins are transmembrane proteins involved in the regulation of mast cell and lung tissue function, including degranulation of mast cells. The preferred protein is a 187 amino acid transmembrane protein having an intercellular domain comprising amino acids 1 through 82, a transmembrane domain comprising amino acids 83 through 105, and an extracellular domain comprising amino acids 106 through 187 (SEQ ID NO:2).
摘要翻译： 与大脑，心脏，肾脏，肝脏，气管和类似组织相比，肥大细胞表达的膜蛋白在人类肥大细胞和肺中高度表达。 蛋白质是涉及肥大细胞和肺组织功能调节的跨膜蛋白，包括肥大细胞的脱颗粒。 优选的蛋白质是187氨基酸跨膜蛋白，其具有包含氨基酸1至82的细胞间结构域，包含氨基酸83至105的跨膜结构域和包含氨基酸106至187（SEQ ID NO：2）的细胞外结构域。
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公开(公告)号：US08753625B2
公开(公告)日：2014-06-17
申请号：US12092346
申请日：2006-11-04
申请人： Sek Chung Fung , Zhengbin Yao
发明人： Sek Chung Fung , Zhengbin Yao
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/18 , A61K38/00 , A61K38/1709 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00 , C12N15/113
摘要： The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases include age-related macular degeneration, diabetic retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5b, C6, C7, C8, C9, or C5b-9.
摘要翻译： 本发明涉及通过施用补体途径抑制剂，特别是替代途径抑制剂来治疗眼部疾病和病症。 眼部疾病包括年龄相关性黄斑变性，糖尿病性视网膜病变和眼血管发生。 一个实施方案包括以全抗体，Fab片段或单结构域抗体的形式施用抗因子D抗体。 可用于本发明方法的其它补体成分抑制剂包括因子H或阻断适当素，因子B，因子Ba，因子Bb，C2，C2a，C3a，C5，C5a，C5b，C6，C7，C8的作用的抑制剂 ，C9或C5b-9。
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13.发明授权公开(公告)号：US06197525B1
公开(公告)日：2001-03-06
申请号：US09022257
申请日：1998-02-11
IPC分类号： G01N33566
CPC分类号： C07K14/54 , A61K38/00 , A61K48/00 , C07K14/7155 , C07K2319/00 , Y10S514/885 , Y10S514/886
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, pharmaceutical compositions made therefrom, detection assays and methods of inhibiting binding of the receports are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译： 公开了用于IL-17的分离的受体，编码这种受体的DNA，由其制备的药物组合物，检测测定法和抑制受体结合的方法。 分离的受体可用于调节免疫应答。
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公开(公告)号：US6072037A
公开(公告)日：2000-06-06
申请号：US22696
申请日：1998-02-12
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61K48/00 , A61P29/00 , A61P37/00 , C07K14/54 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/68 , C07K16/00
CPC分类号： C07K14/54 , C07K14/7155 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S514/885 , Y10S514/886
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, antibodies to such receptors and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译： 公开了用于IL-17的分离的受体，编码这种受体的DNA，对这些受体的抗体以及由其制备的药物组合物。 分离的受体可用于调节免疫应答。
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公开(公告)号：US07754678B2
公开(公告)日：2010-07-13
申请号：US11251734
申请日：2005-10-17
申请人： Yong Guo , Clarence C Morse , Zhengbin Yao , George Keesler
发明人： Yong Guo , Clarence C Morse , Zhengbin Yao , George Keesler
CPC分类号： C07K14/4702 , C07K2319/00 , C07K2319/03 , C07K2319/09 , C07K2319/10 , C07K2319/43 , C07K2319/50 , C07K2319/60 , C12N15/62
摘要： The present invention is directed to membrane penetrating peptides useful as in vivo, ex vivo and in vitro intracellular delivery devices for compound of interest. More particularly, the invention involves identification of membrane penetrating peptides which may be used as protein carriers for delivery of a compound of interest to cells, to methods of delivering a compound of interest attached to membrane penetrating peptides to cells.
摘要翻译： 本发明涉及用作感兴趣化合物的体内，离体和体外细胞内递送装置的膜穿透肽。 更具体地，本发明涉及可以用作蛋白载体的膜穿透肽的鉴定，用于将感兴趣的化合物递送至细胞，将与膜穿透肽连接的感兴趣化合物递送至细胞的方法。
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公开(公告)号：US20090214538A1
公开(公告)日：2009-08-27
申请号：US12092346
申请日：2006-11-04
申请人： Sek Chung Fung , Zhengbin Yao
发明人： Sek Chung Fung , Zhengbin Yao
IPC分类号： A61K39/395 , A61K38/16 , A61K31/7105
CPC分类号： C07K16/18 , A61K38/00 , A61K38/1709 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00 , C12N15/113
摘要： The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor Ocular diseases include age-related macular degeneration, diabetic retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5b, C6, C7, C8, C9, or C5b-9.
摘要翻译： 本发明涉及通过施用补体通路抑制剂，特别是替代途径抑制剂来治疗眼部疾病和病症眼疾病包括年龄相关性黄斑变性，糖尿病性视网膜病变和眼血管发生。 一个实施方案包括以全抗体，Fab片段或单结构域抗体的形式施用抗因子D抗体。 可用于本发明方法的其它补体成分抑制剂包括因子H或阻断适当素，因子B，因子Ba，因子Bb，C2，C2a，C3a，C5，C5a，C5b，C6，C7，C8的作用的抑制剂 ，C9或C5b-9。
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17.发明授权公开(公告)号：US07432237B2
公开(公告)日：2008-10-07
申请号：US10742161
申请日：2003-12-18
IPC分类号： A61K38/00
CPC分类号： C07K14/7155 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S514/885
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译： 公开了用于IL-17的分离的受体，编码这种受体的DNA和由其制备的药物组合物。 分离的受体可用于调节免疫应答。
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公开(公告)号：US5869286A
公开(公告)日：1999-02-09
申请号：US620694
申请日：1996-03-21
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61K48/00 , A61P29/00 , A61P37/00 , C07K14/54 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/68 , C12N1/00
CPC分类号： C07K14/54 , C07K14/7155 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S514/885 , Y10S514/886
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
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19.发明授权Isolated Herpesvirus saimiri proteins that bind MHC Class II molecules 失效分离的疱疹病毒simiri蛋白结合MHC II类分子
公开(公告)号：US5716623A
公开(公告)日：1998-02-10
申请号：US485549
申请日：1995-06-06
IPC分类号： A61K38/00 , C07K14/03 , C12N15/38 , A61K39/12 , A61K39/00 , A61K39/245 , C07C245/00 , C07K1/00
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2710/16422 , Y10S530/826
摘要： Isolated viral proteins, and compositions made therefrom, are disclosed which are capable of binding to Class II Major Histocompatibility Complex antigen, thereby functioning to inhibit an antigen-specific response. The isolated viral proteins also act as superantigens.
摘要翻译： 公开了分离的病毒蛋白质和由其制备的组合物，其能够结合II类主要组织相容性复合物抗原，从而起抑制抗原特异性应答的作用。 分离的病毒蛋白也可以作为超抗原。
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公开(公告)号：US07273843B2
公开(公告)日：2007-09-25
申请号：US10742372
申请日：2003-12-18
IPC分类号： A61K38/00
CPC分类号： C07K14/7155 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S514/885
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译： 公开了用于IL-17的分离的受体，编码这种受体的DNA和由其制备的药物组合物。 分离的受体可用于调节免疫应答。
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