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129 条记录 (耗时 0.057 秒)

    Antibodies specific for phosphorylated insulin receptor substrate-1/2 (Ser1101/Ser1149) and uses thereof
    13.
    发明授权
    Antibodies specific for phosphorylated insulin receptor substrate-1/2 (Ser1101/Ser1149) and uses thereof 有权
    磷酸化胰岛素受体底物-1 / 2（Ser1101 / Ser1149）特异性抗体及其用途

    公开(公告)号：US07731964B2

    公开(公告)日：2010-06-08

    申请号：US10694874

    申请日：2003-10-28

    申请人： Roberto Polakiewicz ,  Jiong Wu ,  Yu Li

    发明人： Roberto Polakiewicz ,  Jiong Wu ,  Yu Li

    IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00

    CPC分类号： C07K16/44 ,  C07K16/18 ,  G01N33/74

    摘要： The invention discloses newly-discovered phosphorylation sites in human IRS-1 and IRS-2, serine 1101 (Ser1101) and serine 1149 (Ser1149) respectively, and provides antibodies, both polyclonal and monoclonal, that selectively bind to IRS-1 and/or IRS-2 when phosphorylated at these respective sites, but do not bind to IRS-1 and/or IRS-2 when not phosphorylated at these respective sites. The sites are relevant to insulin-resistance in type 2 diabetes. Also provided are methods for determining the phosphorylation of IRS-1/2 or activity of PKC theta in a biological sample, by using a detectable reagent, such as the disclosed antibodies, that binds to IRS-1/2 only when phosphorylated at Ser1101/Ser1149. Kits comprising the phosphor-IRS-1/2 (Ser1101/1149) antibodies of the invention are also provided.

    摘要翻译： 本发明公开了分别在人IRS-1和IRS-2，丝氨酸1101（Ser1101）和丝氨酸1149（Ser1149）中新发现的磷酸化位点，并提供选择性结合IRS-1和/或 IRS-2在这些相应位点处磷酸化，但当不在这些相应位点被磷酸化时不结合IRS-1和/或IRS-2。 这些部位与2型糖尿病中的胰岛素抵抗有关。 还提供了通过使用可检测的试剂，例如所公开的抗体，其仅在Ser1101 / 1细胞磷酸化时与IRS-1/2结合才能确定生物样品中IRS-1/2的磷酸化或PKCθ的活性的方法， Ser1149。 还提供了包含本发明的磷光体IRS-1/2（Ser1101 / 1149）抗体的试剂盒。

    Method for measuring pole width of a slider of a disk drive device
    17.
    发明申请
    Method for measuring pole width of a slider of a disk drive device 审中-公开
    用于测量磁盘驱动装置的滑块的磁极宽度的方法

    公开(公告)号：US20090273855A1

    公开(公告)日：2009-11-05

    申请号：US12149527

    申请日：2008-05-02

    申请人： Na He ,  Xinjian Cheng ,  Yu Li

    发明人： Na He ,  Xinjian Cheng ,  Yu Li

    IPC分类号： G11B27/36

    CPC分类号： G11B5/455 ,  G11B5/1871

    摘要： A method for measuring pole width of a slider of a disk drive includes steps of: getting an original image of the pole surface; calculating the light intensity distribution profile of the original image and determining maximum and minimum light intensity data points of the profile; setting average of the maximum and minimum light intensity data points as a threshold; carrying out quadratic differentiation of the profile to obtain a quadratic differential asymptote; determining cross points between the quadratic differential asymptote and the threshold; calculating the distance between the cross points to obtain an initial pole width; and performing data compensation to the initial pole width to obtain a compensated pole width. The method may also measure the distance between edges of other micro-objects.

    摘要翻译： 用于测量磁盘驱动器的滑块的磁极宽度的方法包括以下步骤：获得磁极表面的原始图像; 计算原始图像的光强分布曲线并确定轮廓的最大和最小光强数据点; 将最大和最小光强数据点的平均值设置为阈值; 对轮廓进行二次微分，得到二次微分渐近线; 确定二次微分渐近线与阈值之间的交叉点; 计算交叉点之间的距离以获得初始极宽度; 并对初始极宽进行数据补偿以获得补偿的极宽。 该方法还可以测量其他微物体的边缘之间的距离。

    BUS ENCODING/DECODING METHOD AND BUS ENCODER/DECODER
    18.
    发明申请
    BUS ENCODING/DECODING METHOD AND BUS ENCODER/DECODER 失效
    总线编码/解码方法和总线编码器/解码器

    公开(公告)号：US20090193159A1

    公开(公告)日：2009-07-30

    申请号：US12360914

    申请日：2009-01-28

    申请人： Yu Li ,  Haibo Lin ,  Wen Bo Shen ,  Kai Zheng

    发明人： Yu Li ,  Haibo Lin ,  Wen Bo Shen ,  Kai Zheng

    IPC分类号： G06F13/32

    CPC分类号： H04L25/4906 ,  G06F1/3253 ,  G06F9/3802 ,  Y02D10/151

    摘要： An encoding method and an encoder for encoding data transmitted in a manner of bursts via a parallel bus and a decoding method and a decoder. The encoding method includes organizing data of the bursts into matrixes, determining for each of the matrixes whether a transform mode capable of decreasing the bus transition number exists, determining that the matrix needs to be transformed, determining a transform mode for transforming the matrix, and replacing the initial matrix with the transformed matrix. Then, forming a new matrix to be transmitted from matrixes which do not need to be transformed and matrixes which have been transformed. Thereafter, first generating a transform information word indicating transform states of the respective matrixes and then attaching the transform information word to the matrix to be transmitted to form an encoded matrix for actual transmission.

    摘要翻译： 一种编码方法和编码器，用于经由并行总线和解码方法以及解码器对以脉冲串的方式发送的数据进行编码。 该编码方法包括将脉冲串的数据组织成矩阵，确定每个矩阵是否存在能够减小总线转换数的变换模式，确定矩阵需要变换，确定用于转换矩阵的变换模式，以及 用转换的矩阵代替初始矩阵。 然后，形成要从不需要变换的矩阵发送的新矩阵和已经被变换的矩阵。 此后，首先产生指示各个矩阵的变换状态的变换信息字，然后将变换信息字附加到要发送的矩阵，以形成用于实际发送的编码矩阵。

    Method and apparatus for determining a hemodynamic response function for event-related functional magnetic resonance imaging
    20.
    发明申请
    Method and apparatus for determining a hemodynamic response function for event-related functional magnetic resonance imaging 审中-公开
    用于确定事件相关功能磁共振成像的血液动力学响应函数的方法和装置

    公开(公告)号：US20070287904A1

    公开(公告)日：2007-12-13

    申请号：US11788586

    申请日：2007-04-20

    申请人： Yu Li ,  Mark Limkeman

    发明人： Yu Li ,  Mark Limkeman

    IPC分类号： A61B5/055

    CPC分类号： G01R33/4806 ,  A61B5/055 ,  A61B5/7257 ,  G01R33/58

    摘要： Embodiments of the subject invention can involve a method of suppressing noise in hemodynamic deconvolution for event-related functional MR imaging (ER-fMRI). A typical ER-fMRI experiment measures the Blood Oxygenation Level Dependent (BOLD) response to a series of sparse, short-duration stimuli. Based on the deconvolution of a hemodynamic response function (HRF) from the BOLD signal and event stimulus function, the neuronal activation can be localized to specific brain regions and tracked on the order of a second. ER-fMRI can be used to study the temporal dynamics of neuronal network. However, in certain situations, aliasing noise can be generated in hemodynamic deconvolution due to the low sampling rate limited by the imaging speed. This aliasing noise can reduce the accuracy of temporal characterization of the HRF. In an embodiment, by incorporating the use of a phantom having one or more coil loops positioned perpendicular to the magnetic field Bo, such that DC current inputted into one of the loops will produce field distortion to Bo, an ER-fMRI experiment can be calibrated and the temporal measurement of HRF can be improved with the removal of aliasing noise.

    摘要翻译： 本发明的实施例可以涉及一种抑制事件相关功能MR成像（ER-fMRI）的血流动力学去卷积噪声的方法。 典型的ER-fMRI实验测量血液氧合水平依赖（BOLD）对一系列稀疏，短期刺激的反应。 基于来自BOLD信号和事件刺激函数的血液动力学响应函数（HRF）的去卷积，神经元激活可以被定位到特定的脑区域并以一秒的顺序进行跟踪。 ER-fMRI可用于研究神经元网络的时间动力学。 然而，在某些情况下，由于由成像速度限制的低采样率，可以在血流动力学反卷积中产生混叠噪声。 这种混叠噪声可以降低HRF的时间表征的准确性。 在一个实施例中，通过结合使用具有垂直于磁场B 0的一个或多个线圈环的体模，使得输入到一个环路中的DC电流将产生场失真到B < 可以校准ER-fMRI实验，并且可以通过去除混叠噪声来改善HRF的时间测量。