摘要:
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
摘要:
Systems, methods, and computer programs encoded on a computer-readable storage medium for allocating a minimum number of impressions to a content item in order to satisfy a delivery goal for the content item during a certain period of time are described. In some implementations, a satisfaction index (SI) for each content item can be used. The SI is a metric that reflects the degree to which a content selection service is on pace to meet a delivery goal for a content item within some period. The SI can be used to compare the number of impressions that have been allocated to the content item thus far in a period to the delivery or allocation goal for the content item in the period. A content selection service may determine scores for impression allocations based on both an estimate of value and the SI for a candidate content item in order to balance the goals of meeting delivery goals and optimizing impression inventory value.
摘要:
The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要:
Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease
摘要:
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
摘要:
Techniques for improving a troubleshooting experience by providing a common troubleshooting framework. Such a framework may enable use of common elements between troubleshooters and lead to similarities between troubleshooting packages, which may improve the user experience. Further, a framework may reduce the amount of knowledge and time necessary to create troubleshooting packages, and thus encourage increased development of these troubleshooting packages. In some implementations of the framework, a troubleshooting package may be implemented in a declarative manner that outlines/describes the problems it solves and the potential solutions to those problems. The declarative troubleshooting packages may then be provided to the troubleshooting framework and may provide direction to the framework, in that the framework may execute functions as directed by the troubleshooter.
摘要:
Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要:
A computer configured to operate in diagnostic mode during which the operating system is suspended. During the diagnostic mode, tests can be performed on the computer system, including hardware, and the tests do not disrupt the operating system and are not disrupted by the operating system. When diagnostic mode is triggered, execution of the operating system is suspended. When the diagnostic tests are completed, the operating system may resume operation and test data may be made available within the operating system environment. Upon resuming, the state of the computer prior to entering diagnostic mode may be restored, preventing any changes made during diagnostic mode from interfering with operation of the operating system or application components.
摘要:
Methods, systems and computer program products for estimating a CPC bid (eCPC) as a function of a target CPA bid based on predictive data (e.g., predicted conversion rate) have been described. The eCPC parameter can be used to develop a model that could be used to charge advertisers on a CPA basis while crediting publishers on a CPC basis.
摘要:
Briefly described, embodiments of this disclosure include polypeptides, in particular a labeled VEGF protein, kits for imaging, methods for imaging tissue, methods of diagnosing the presence in a tissue of one or more of precancerous cells, cancerous cells, tumor cells, and cells related to ischemic or hypoxic related diseases, methods of monitoring the progress in a tissue of the presence of one or more of precancerous cells, cancerous cells, tumor cells, and cells related to ischemic or hypoxic related diseases, and the like.