公开(公告)号：US20160231236A1

公开(公告)日：2016-08-11

申请号：US15081465

申请日：2016-03-25

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  John L. Smith ,  William Van Antwerp

IPC: G01N21/359 ,  A61B5/1455 ,  G01N33/483 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The collection of radiation and/or illumination is controlled either to target a particular volume of the medium or such that the spectral energy changes become directionally monotonic with respect to analyte concentration, or both. The collection parameters include: duration of collection, location and/or a size of a collection spot on the medium surface, and angle of a collector relative to the medium surface. The illuminated and/or collection spots may be treated to improve accuracy of analyte measurement.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，照射被引导到介质并收集来自培养基的相应辐射。 使用碰撞计算确定与从收集的辐射获得的片段/特征相关联的光谱能量变化。 这种光谱能量变化通常表示分析物浓度。 控制辐射和/或照明的收集以靶向介质的特定体积，或者使得光谱能量变化相对于分析物浓度变得朝向单调，或两者。 收集参数包括：介质表面上的收集点的持续时间，位置和/或收集点的大小以及收集器相对于介质表面的角度。 可以处理照明和/或收集点以提高分析物测量的准确度。

公开(公告)号：US20160139043A1

公开(公告)日：2016-05-19

申请号：US14993905

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/3577 ,  G01N33/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves. Analyte concentration in the uncharacterized medium can be reliably computed at a specified high level of accuracy using the spectral-energy change associated therewith and the selected curve.

Abstract translation: 合成投影系统从与可能存在分析物的介质的非特征实例相关联的光谱能量变化来确定分析物浓度，例如血糖浓度。 投影系统在不同实例的介质下进行出厂校准，无需实例特定的训练或校准。 投影系统包括一组投影仪曲线，每个投影仪曲线都将通过分析参考介质样品获得的光谱能量变化值与这些样品中的分析物浓度相关联。 每个投影仪曲线也对应于能量变化梯度的相应范围，使用一组代用介质，其特征在于使用参考系统测量的分析物浓度。 可以计算未表征介质的光谱能量变化梯度以选择投影仪曲线之一。 使用与其相关联的光谱能量变化和所选择的曲线，可以以指定的高精确度可靠地计算未表征介质中的分析物浓度。

公开(公告)号：US20160139041A1

公开(公告)日：2016-05-19

申请号：US14993830

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/3577 ,  G01N33/49 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A collision-computing system detects and amplifies the energy associated with a feature signal to determine occurrences or absence of events, such as ultrasonic and/or geophysical events, or to determine presence and/or concentrations of substances such as blood glucose, toxic chemicals, etc., in a noisy, high-clutter environment or sample. To this end, a conditioned feature, obtained by modulating a carrier kernel with a feature signal, is collided with a Zyoton—a waveform that without a collision can travel substantially unperturbed in a propagation medium over a specified distance. The conditioned feature and the Zyoton are particularly constructed to be co-dependent in terms of their respective dispersion velocities and the divergence of a waveform resulting from the collision. The collision operation can transfer at least a portion of the feature energy to the resulting waveform, and the transferred energy can be amplified in successive collisions for detecting/measuring events/substances.

Abstract translation: 碰撞计算系统检测和放大与特征信号相关联的能量，以确定诸如超声波和/或地球物理事件之类的事件的出现或不存在，或者确定物质的存在和/或浓度，例如血糖，有毒化学物质， 等等，在嘈杂，高杂乱的环境或样品中。 为此，通过调制具有特征信号的载体核获得的调节特征与Zyoton-a波形相撞，其中没有碰撞可以在传播介质中在特定距离上基本上不受干扰地行进。 调节特征和Zyoton特别构造为在它们各自的分散速度和由碰撞产生的波形的发散度方面是共同依赖的。 碰撞操作可以将特征能量的至少一部分转移到所得到的波形，并且传送的能量可以在连续的碰撞中被放大以用于检测/测量事件/物质。