公开(公告)号：US09766126B2

公开(公告)日：2017-09-19

申请号：US13941389

申请日：2013-07-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Thomas George ,  Timothy L. Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC: A61B5/1455 ,  G01J3/42 ,  G01N21/47 ,  A61B5/00 ,  A61B5/107 ,  A61B5/145

CPC classification number: G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

Abstract: An analyzer apparatus and method of use thereof is described to dynamically irradiate a sample with incident light where the incident light is varied in time in terms of any of: position, radial position relative to a point of the skin of a subject, solid angle, incident angle, depth of focus, energy, and/or intensity. For example, the incident light is varied in radial position as a function of time relative to one or more of a sample site, a point on skin of the subject, a detection optic, and/or a sample volume observed by a detection system. The radially varied incident light is used to enhance and/or vary light probing the epidermis, the dermis, and/or the subcutaneous fat of the subject or of a group of subjects.

公开(公告)号：US09442065B2

公开(公告)日：2016-09-13

申请号：US14993885

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti

IPC: G01J5/02 ,  G01N21/3577 ,  A61B5/024 ,  G01N21/359 ,  G01N21/47 ,  G01N21/49 ,  G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A synthesizer synthesizes Zyotons, waveforms that without a collision can travel substantially unperturbed in a propagation medium over a specified distance, for extracting via collision computing properties of interest of signals, such as the occurrence/absence of events and presence or concentrations of substances such as blood glucose, toxic chemicals, etc., obtained from high noise/clutter environments. The Zyotons are synthesized using base waveform families/generator functions unrelated to the signal environment. The Zyotons and corresponding carrier kernels include component(s) adapted to correspond to a signal property of interest and other component(s) adapted to correspond to other properties, such as noise and clutter. The number of each type of component(s) may be determined using a representative signal obtained from the environment that is optionally transformed via derivitization, addition of noise and/or another representative signal, etc. A base waveform family/generator function can be selected according to the representative signal morphology.

Abstract translation: 合成器合成Zyotons，没有碰撞的波形可以在传播介质中在特定距离内基本上不受干扰地传播，用于通过诸如事件的发生/不存在以及物质的存在或浓度（例如， 血糖，有毒化学物质等，从高噪声/杂波环境中获得。 Zyotons使用与信号环境无关的基本波形族/发生器功能合成。 Zyotons和相应的载体内核包括适于对应于感兴趣的信号特性的组件和适于对应于诸如噪声和杂波的其他性质的其它组件的组件。 可以使用从环境获得的代表信号来确定每种类型的组件的数量，所述代表性信号可选地通过衍生化，噪声的添加和/或其他代表性信号进行变换。可以选择基本波形族/发生器功能 根据代表信号的形态。

公开(公告)号：US20160231235A1

公开(公告)日：2016-08-11

申请号：US15081430

申请日：2016-03-25

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/359 ,  A61B5/1455 ,  A61B5/145 ,  G01N33/483

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The illumination is controlled to target a particular volume of the medium and/or such that the spectral energy changes become directionally monotonic with respect to analyte concentration. The illumination parameters include: intensity, wavelength, bandwidth, focal length, and/or duration of illumination, location and/or a size of an illuminated spot on the medium surface, depth at which the illumination can reach below the medium surface, spacing between the illuminated spot and a spot on the medium surface from which radiation is collected, and angle of the illumination relative to the medium surface.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，照射被引导到介质并收集来自培养基的相应辐射。 使用碰撞计算确定与从收集的辐射获得的片段/特征相关联的光谱能量变化。 这种光谱能量变化通常表示分析物浓度。 控制照明以靶向介质的特定体积和/或使得光谱能量变化相对于分析物浓度变得方向性单调。 照明参数包括：照明的强度，波长，带宽，焦距和/或持续时间，介质表面上的照明光斑的位置和/或尺寸，照明可以到达介质表面下方的深度， 照明光斑和收集辐射的介质表面上的光点以及相对于介质表面的照明角度。

公开(公告)号：US20160139045A1

公开(公告)日：2016-05-19

申请号：US14993819

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/47 ,  A61B5/024 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，来自培养基的光谱被解构为特征。 包含特定于葡萄糖或其他分析物的频率分量的条件特征通过调制具有该特征的载体核心从一个或多个特征导出。 条件特征与一个或多个与条件特征相关的Zyotons计算相撞。 一个或多个碰撞放大分析物的性质，例如组织中由葡萄糖吸收的能量，辐射被引导到皮肤。 使用放大性能的几个值的梯度，每个值对应于根据光谱断层扫描序列的特定辐射图，其值被选择合适的投影仪曲线，其中代表性的放大值被预测为准确地估计浓度 葡萄糖或其他分析物，不需要个性化校准。

公开(公告)号：US09610018B2

公开(公告)日：2017-04-04

申请号：US15233474

申请日：2016-08-10

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  John L. Smith

IPC: G01J5/02 ,  A61B5/024 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/49 ,  G01N33/483 ,  G01N33/49 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for measurement of heart rate and other heart-related characteristics a photoplethysmogram (PPG) obtained from a tissue is divided into several feature waveforms, each corresponding to a PPG window of a particular length. Conditioned features, containing frequency components specific to heart-related events, are derived from the features by modulating a carrier kernel with such features. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. For each conditioned feature, one or more collisions selectively amplify frequency components in features sourced from PPG, and respective energy change values are obtained from such amplified energy portions. The resulting energy change values are analyzed to determine a smallest time-window likely containing heart rate and other heart-related events in the PPG data stream. Over time, the detected events are grouped and analyzed to determine heart rate and other heart-related characteristics.

公开(公告)号：US09459203B2

公开(公告)日：2016-10-04

申请号：US14993905

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01J5/02 ,  G01N21/3577 ,  A61B5/024 ,  G01N21/359 ,  G01N21/47 ,  G01N21/49 ,  G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves. Analyte concentration in the uncharacterized medium can be reliably computed at a specified high level of accuracy using the spectral-energy change associated therewith and the selected curve.

Abstract translation: 合成投影系统从与可能存在分析物的介质的非特征实例相关联的光谱能量变化来确定分析物浓度，例如血糖浓度。 投影系统在不同实例的介质下进行出厂校准，无需实例特定的训练或校准。 投影系统包括一组投影仪曲线，每个投影仪曲线都将通过分析参考介质样品获得的光谱能量变化值与这些样品中的分析物浓度相关联。 每个投影仪曲线也对应于能量变化梯度的相应范围，使用一组代用介质，其特征在于使用参考系统测量的分析物浓度。 可以计算未表征介质的光谱能量变化梯度以选择投影仪曲线之一。 使用与其相关联的光谱能量变化和所选择的曲线，可以以指定的高精确度可靠地计算未表征介质中的分析物浓度。

公开(公告)号：US09459201B2

公开(公告)日：2016-10-04

申请号：US14869550

申请日：2015-09-29

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William V. Antwerp ,  John L. Smith

IPC: G01J5/02 ,  G01N21/3577 ,  A61B5/024 ,  G01N21/359 ,  G01N21/47 ,  G01N21/49 ,  G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.

公开(公告)号：US09453794B2

公开(公告)日：2016-09-27

申请号：US15081430

申请日：2016-03-25

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01J5/02 ,  G01N21/359 ,  G01N33/483 ,  A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, illumination is directed to the medium and corresponding radiation from the medium is collected. Spectral energy changes associated with fragment(s)/feature(s) obtained from the collected radiation are determined using collision computing. Such spectral energy changes generally represent analyte concentration. The illumination is controlled to target a particular volume of the medium and/or such that the spectral energy changes become directionally monotonic with respect to analyte concentration. The illumination parameters include: intensity, wavelength, bandwidth, focal length, and/or duration of illumination, location and/or a size of an illuminated spot on the medium surface, depth at which the illumination can reach below the medium surface, spacing between the illuminated spot and a spot on the medium surface from which radiation is collected, and angle of the illumination relative to the medium surface.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，照射被引导到介质并收集来自培养基的相应辐射。 使用碰撞计算确定与从收集的辐射获得的片段/特征相关联的光谱能量变化。 这种光谱能量变化通常表示分析物浓度。 控制照明以靶向介质的特定体积和/或使得光谱能量变化相对于分析物浓度变得方向性单调。 照明参数包括：照明的强度，波长，带宽，焦距和/或持续时间，介质表面上的照明光斑的位置和/或尺寸，照明可以到达介质表面下方的深度， 照明光斑和收集辐射的介质表面上的光点以及相对于介质表面的照明角度。

公开(公告)号：US09448164B2

公开(公告)日：2016-09-20

申请号：US14993819

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01J5/02 ,  G01N21/3577 ,  A61B5/024 ,  G01N21/359 ,  G01N21/47 ,  G01N21/49 ,  G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，来自培养基的光谱被解构为特征。 包含特定于葡萄糖或其他分析物的频率分量的条件特征通过调制具有该特征的载体核心从一个或多个特征导出。 条件特征与一个或多个与条件特征相关的Zyotons计算相撞。 一个或多个碰撞放大分析物的性质，例如组织中由葡萄糖吸收的能量，辐射被引导到皮肤。 使用放大性能的几个值的梯度，每个值对应于根据光谱断层扫描序列的特定辐射图，其值被选择合适的投影仪曲线，其中代表性的放大值被预测为准确地估计浓度 葡萄糖或其他分析物，不需要个性化校准。

公开(公告)号：US20170156646A1

公开(公告)日：2017-06-08

申请号：US15239309

申请日：2016-08-17

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: A61B5/145 ,  A61B5/1455 ,  G01N33/49 ,  G01N21/49 ,  G01N21/359 ,  G01N33/483

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.