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419 条记录 (耗时 0.067 秒)

    PHENYLPYRROLE DERIVATIVE
    13.
    发明申请
    PHENYLPYRROLE DERIVATIVE 有权
    PHYYLPYRROLE DERIVATIVE

    公开(公告)号：US20140330010A1

    公开(公告)日：2014-11-06

    申请号：US14362939

    申请日：2012-12-07

    申请人： TAISHO PHARMACEUTICAL CO., LTD.

    发明人： Toshio Nakamura ,  Seiji Masuda

    IPC分类号： C07D491/107 ,  C07D413/14 ,  C07D403/12 ,  C07D401/12

    CPC分类号： A61K31/454 ,  A61K31/4025 ,  A61K31/5377 ,  C07D401/12 ,  C07D403/12 ,  C07D413/14 ,  C07D491/107

    摘要： Provided are novel compounds that are useful in the prevention or treatment of such diseases as dementia, Alzheimer's disease, attention-deficient hyperactivity disorder, schizophrenia, epilepsy, central convulsion, obesity, diabetes mellitus, hyperlipidemia, narcolepsy, idiopathic hypersomnia, behaviorally induced insufficient sleep syndrome, sleep apnea syndrome, circadian rhythm disorder, parasomnia, sleep related movement disorder, insomnia, and depression, or allergic rhinitis, or pharmaceutically acceptable salts of such compounds. Specifically, there are provided phenylpyrrole compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof:Formula (I) [wherein Q refers to a group represented by the following formula (A) or (B):

    摘要翻译： 提供了可用于预防或治疗诸如痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，癫痫，中枢抽搐，肥胖症，糖尿病，高脂血症，发作性睡眠，特发性睡眠过度，行为诱发的不足睡眠等疾病的新型化合物 综合征，睡眠呼吸暂停综合征，昼夜节律紊乱，睡眠睡眠，睡眠相关的运动障碍，失眠和抑郁症，或过敏性鼻炎，或这些化合物的药学上可接受的盐。 具体地，提供下式（I）表示的苯基吡咯化合物或其药学上可接受的盐：式（I）[其中Q表示由下式（A）或（B）表示的基团：

    Glycine transporter-inhibiting substances
    15.
    发明授权
    Glycine transporter-inhibiting substances 有权
    甘氨酸转运蛋白抑制物质

    公开(公告)号：US08796272B2

    公开(公告)日：2014-08-05

    申请号：US14000261

    申请日：2012-02-21

    申请人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

    发明人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

    IPC分类号： A61K31/50 ,  A61K31/501

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention relates to novel compounds of formula [I] or pharmaceutically acceptable salts thereof: The compounds of the present invention are useful in the prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, spasm, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder, or sleep disorders, which is based on the glycine uptake-inhibiting action.

    摘要翻译： 本发明涉及式[I]的新化合物或其药学上可接受的盐：本发明的化合物可用于预防或治疗诸如精神分裂症，阿尔茨海默氏病，认知障碍，痴呆，焦虑症（例如， 广泛性焦虑症，恐慌症，强迫症，社交焦虑症，创伤后应激障碍，特异性恐惧症，急性应激障碍），抑郁症，药物依赖性，痉挛，震颤，疼痛，帕金森病，注意缺陷多动障碍，双相 紊乱，进食障碍或睡眠障碍，其基于甘氨酸摄取抑制作用。

    Dihydroquinolinone derivatives
    16.
    发明授权
    Dihydroquinolinone derivatives 有权
    二氢喹啉酮衍生物

    公开(公告)号：US08609847B2

    公开(公告)日：2013-12-17

    申请号：US13144591

    申请日：2010-02-05

    申请人： Toshio Nakamura ,  Seiji Masuda ,  Aya Futamura

    发明人： Toshio Nakamura ,  Seiji Masuda ,  Aya Futamura

    IPC分类号： C07D215/38

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

    摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A dihydroquinolinone derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein Q represents the following formula (A) or (B)}

    摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的二氢喹啉酮衍生物或其药学上可接受的盐：其中Q表示下式（A）或（B）}

    Phenylpyrazole derivatives
    20.
    发明授权
    Phenylpyrazole derivatives 有权
    苯基吡唑衍生物

    公开(公告)号：US08183387B2

    公开(公告)日：2012-05-22

    申请号：US12951964

    申请日：2010-11-22

    申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

    发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

    IPC分类号： C07D231/10

    CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

    摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

    摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。