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公开(公告)号:US08524738B2
公开(公告)日:2013-09-03
申请号:US13463434
申请日:2012-05-03
申请人: Taro Kiyoto , Tadashi Tanaka , Yasuhiro Tsutsui , Junichi Ando , Mai Motono , Yasuko Kawaguchi , Toshiya Noguchi , Yasunobu Ushiki , Fumihito Ushiyama , Hiroki Urabe
发明人: Taro Kiyoto , Tadashi Tanaka , Yasuhiro Tsutsui , Junichi Ando , Mai Motono , Yasuko Kawaguchi , Toshiya Noguchi , Yasunobu Ushiki , Fumihito Ushiyama , Hiroki Urabe
IPC分类号: A61K31/47
CPC分类号: C07D405/14 , C07D215/227 , C07D401/06 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要: A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.
摘要翻译: 由通式表示的含氮杂环化合物或其药学上可接受的盐,其具有强的抗菌活性和高安全性。 因此,这些化合物可用作抗革兰氏阳性细菌,革兰氏阴性细菌和耐药细菌的抗菌剂。
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公开(公告)号:US08329694B2
公开(公告)日:2012-12-11
申请号:US11993652
申请日:2006-06-22
申请人: Taro Kiyoto , Tadashi Tanaka , Yasuhiro Tsutsui , Junichi Ando , Mai Motono , Yasuko Kawaguchi , Toshiya Noguchi , Yasunobu Ushiki , Fumihito Ushiyama , Hiroki Urabe
发明人: Taro Kiyoto , Tadashi Tanaka , Yasuhiro Tsutsui , Junichi Ando , Mai Motono , Yasuko Kawaguchi , Toshiya Noguchi , Yasunobu Ushiki , Fumihito Ushiyama , Hiroki Urabe
IPC分类号: A61K31/495
CPC分类号: C07D405/14 , C07D215/227 , C07D401/06 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要: A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.
摘要翻译: 由通式表示的含氮杂环化合物或其药学上可接受的盐,其具有强的抗菌活性和高安全性。 因此,这些化合物可用作抗革兰氏阳性细菌,革兰氏阴性细菌和耐药细菌的抗菌剂。
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公开(公告)号:US20120214990A1
公开(公告)日:2012-08-23
申请号:US13463434
申请日:2012-05-03
申请人: Taro KIYOTO , Tadashi Tanaka , Yasuhiro Tsutsui , Junichi Ando , Mai Motono , Yasuko Kawaguchi , Toshiya Noguchi , Yasunobu Ushiki , Fumihito Ushiyama , Hiroki Urabe
发明人: Taro KIYOTO , Tadashi Tanaka , Yasuhiro Tsutsui , Junichi Ando , Mai Motono , Yasuko Kawaguchi , Toshiya Noguchi , Yasunobu Ushiki , Fumihito Ushiyama , Hiroki Urabe
IPC分类号: C07D405/14 , C07D491/056 , C07D413/14 , C07D417/14 , C07D513/04 , C07D498/04 , C07D471/04 , C07D401/06 , C07D495/04 , C07D401/14 , C07D405/12 , C07D215/22 , C07D409/14 , C07D455/04
CPC分类号: C07D405/14 , C07D215/227 , C07D401/06 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要: A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.
摘要翻译: 由通式表示的含氮杂环化合物或其药学上可接受的盐,其具有强的抗菌活性和高安全性。 因此,这些化合物可用作抗革兰氏阳性细菌,革兰氏阴性细菌和耐药细菌的抗菌剂。
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公开(公告)号:US09073821B2
公开(公告)日:2015-07-07
申请号:US13642320
申请日:2011-04-20
申请人: Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
发明人: Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
IPC分类号: C07C259/06 , C07C323/62 , C07D305/06 , C07D307/14 , C07D317/30 , C07D319/18 , C07D295/08 , C07D285/12 , C07D271/12 , C07D265/30 , C07D263/14 , C07D261/08 , C07D241/04 , C07C271/22 , C07C271/28 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07D205/12 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/12 , C07D231/56 , C07D257/04 , C07D263/32 , C07D263/56 , C07D265/38 , C07D267/10 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/08 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/60 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/08 , C07F9/09 , C07D239/26 , C07D235/04 , C07D233/61 , C07D231/12 , C07D217/04 , C07D211/14 , C07D209/08 , C07D207/10 , C07D205/04
CPC分类号: C07C233/83 , C07C235/84 , C07C237/36 , C07C259/06 , C07C271/22 , C07C271/28 , C07C309/30 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07D205/04 , C07D205/12 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/04 , C07D217/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D235/04 , C07D257/04 , C07D261/08 , C07D263/14 , C07D263/32 , C07D263/56 , C07D265/30 , C07D265/36 , C07D265/38 , C07D267/10 , C07D271/12 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D285/12 , C07D295/08 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/06 , C07D305/08 , C07D307/14 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/81 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/30 , C07D317/60 , C07D319/18 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/04 , C07D498/08 , C07F9/091
摘要: Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:
摘要翻译: 提供了通过抑制LpxC活性可用作药物组合物的新型化合物,从而对包括绿脓假单胞菌及其耐药细菌在内的革兰氏阴性细菌表现出有效的抗微生物活性。 提供由以下通式[1]表示的异羟肟酸衍生物或其药学上可接受的盐:
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公开(公告)号:US20130072677A1
公开(公告)日:2013-03-21
申请号:US13642320
申请日:2011-04-20
申请人: Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
发明人: Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
IPC分类号: C07C259/06 , C07D267/10 , C07D261/08 , C07D205/04 , C07D211/46 , C07D498/04 , C07D305/08 , C07D491/107 , C07D307/52 , C07D295/155 , C07D413/06 , C07D265/36 , C07D295/088 , C07D305/06
CPC分类号: C07C233/83 , C07C235/84 , C07C237/36 , C07C259/06 , C07C271/22 , C07C271/28 , C07C309/30 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07D205/04 , C07D205/12 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/04 , C07D217/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D235/04 , C07D257/04 , C07D261/08 , C07D263/14 , C07D263/32 , C07D263/56 , C07D265/30 , C07D265/36 , C07D265/38 , C07D267/10 , C07D271/12 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D285/12 , C07D295/08 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/06 , C07D305/08 , C07D307/14 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/81 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/30 , C07D317/60 , C07D319/18 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/04 , C07D498/08 , C07F9/091
摘要: Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:
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公开(公告)号:US20100168418A1
公开(公告)日:2010-07-01
申请号:US11993652
申请日:2006-06-22
申请人: Taro Kiyoto , Tadashi Tanaka , Yasuhiro Tsutsui , Junichi Ando , Mai Motono , Yasuko Kawaguchi , Toshiya Noguchi , Yasunobu Ushiki , Fumihito Ushiyama , Hiroki Urabe
发明人: Taro Kiyoto , Tadashi Tanaka , Yasuhiro Tsutsui , Junichi Ando , Mai Motono , Yasuko Kawaguchi , Toshiya Noguchi , Yasunobu Ushiki , Fumihito Ushiyama , Hiroki Urabe
IPC分类号: C07D513/06 , C07D401/06 , C07D405/14 , C07D493/04 , C07D409/14
CPC分类号: C07D405/14 , C07D215/227 , C07D401/06 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要: A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R1, R2, R3, R4 and R5 independently represent a hydrogen atom, halogen atom, a lower alkyl, aryl, lower alkoxy or monocyclic heterocyclic group which may be substituted or the like; R6 represents a lower alkyl, aryl, monocyclic heterocyclic, bicyclic heterocyclic or tricyclic heterocyclic group which may be substituted; X1 represents a lower alkylene group or the like; X2 represents a lower alkylene, lower alkenylene or lower alkynylene group which may be substituted; X3 represents an oxygen atom, sulfur atom, a sulfinyl group, sulfonyl group or the like; Y1 represents a bivalent cyclic group, containing a nitrogen, which may be substituted or the like; and Z1 represents a nitrogen atom, a carbon atom which may be substituted or the like, or a salt thereof. The compound or salt has a potent antibacterial activity and a high safety, and is therefore useful as an excellent antibacterial agent.
摘要翻译: 由以下通式表示的含氮杂环化合物:其中虚线表示单键或双键; R1,R2,R3,R4和R5独立地表示氢原子,卤原子,可被取代的低级烷基,芳基,低级烷氧基或单环杂环基等; R6代表可被取代的低级烷基,芳基,单环杂环,双环杂环或三环杂环基; X1表示低级亚烷基等; X2表示可以被取代的低级亚烷基,低级亚烯基或低级亚烷基; X3表示氧原子,硫原子,亚磺酰基,磺酰基等; Y1表示含有氮的二价环状基团,其可以被取代等; Z1表示氮原子,可以被取代的碳原子等,或其盐。 该化合物或盐具有有效的抗菌活性和高安全性,因此可用作优异的抗菌剂。
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