公开(公告)号：US20220090085A1

公开(公告)日：2022-03-24

申请号：US17380773

申请日：2021-07-20

申请人： The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads

发明人： Melanie Ott ,  Daniela Boehm

IPC分类号： C12N15/113 ,  A61K38/15 ,  A61K45/06 ,  A61K31/19 ,  A61K31/22 ,  A61K31/365 ,  A61K31/551 ,  A61K31/713 ,  A61K31/167 ,  A61K31/222

摘要： The present disclosure provides compositions and methods for reactivating latent immunodeficiency virus and/or reducing transcription of HIV integrated into the genome of an HIV-infected cell. The present disclosure provides compositions and methods for treating an immunodeficiency virus infection.

公开(公告)号：US20210395746A1

公开(公告)日：2021-12-23

申请号：US17251395

申请日：2019-06-12

申请人： The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads

发明人： Leor S. Weinberger ,  Sonali Chaturvedi

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K31/522 ,  A61K31/662 ,  A61K31/675 ,  A61K31/7056

摘要： The present disclosure provides compositions and methods for inhibiting herpesvirus replication in a cell infected with herpesvirus. The composition includes a double stranded DNA molecule including a sequence of a cis regulatory sequence (crs) of a herpesvirus, wherein the crs is flanked on the 5′ end by a first sequence of at least 2 base pairs and on the 3′ end by a second sequence of at least 2 base pairs.

公开(公告)号：US10889538B2

公开(公告)日：2021-01-12

申请号：US16306524

申请日：2017-06-02

申请人： THE J. DAVID GLADSTONE INSTITUTES ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ITHACA COLLEGE

发明人： Eric Verdin ,  Scott Michael Ulrich ,  John C. Newman

IPC分类号： C07C69/34 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00 ,  A61P13/12 ,  A61P9/10 ,  G02B1/04 ,  A61K31/23 ,  A23L33/12

摘要： Aspects of the present disclosure include fatty acid β-hydroxyester compounds (e.g., fatty acid esters of β-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid β-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.

公开(公告)号：US20200239541A1

公开(公告)日：2020-07-30

申请号：US16774567

申请日：2020-01-28

申请人： Xyphos Biosciences Inc. ,  The J. David Gladstone Institutes, A Testamentary Trust Established Under the Will of J. David Glast

发明人： Kaman KIM ,  Nigel KILLEEN ,  Eytan HERZIG ,  Warner GREENE

IPC分类号： C07K14/705 ,  C07K16/10 ,  C07K14/16

摘要： This application relates generally to the production of modified, non-natural α1-α2 domains of NKG2D ligands with attached polypeptides having specific target-binding properties, for example, antibodies or variable fragments of antibodies, that are selectively delivered to Chimeric Antigen Receptors (CARs) comprised of modified, non-natural NKG2D receptors on engineered mammalian cells. The targeting of surface-expressed molecules includes those of virus-infected cells that can then be attacked and ablated by engineered cells of the immunity system expressing CARs cognate to the modified, non-natural α1-α2 domains of NKG2D ligands with attached polypeptides.

公开(公告)号：US10562839B2

公开(公告)日：2020-02-18

申请号：US16525437

申请日：2019-07-29

申请人： The J. David Gladstone Institutes ,  The Regents of the University of California ,  Ithaca College

发明人： Eric Verdin ,  Scott Michael Ulrich ,  John C. Newman

IPC分类号： C07C69/34 ,  A23L33/12 ,  A61P9/10 ,  A61P25/28 ,  A61P13/12 ,  A61P25/08 ,  A61P25/16 ,  A61P35/00

摘要： Aspects of the present disclosure include fatty acid β-hydroxyester compounds (e.g., fatty acid esters of β-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid β-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.

公开(公告)号：US10247735B2

公开(公告)日：2019-04-02

申请号：US15332882

申请日：2016-10-24

申请人： The J. David Gladstone Institutes

发明人： Katerina Akassoglou

IPC分类号： C07K7/08 ,  C12Q1/54 ,  A61K38/10 ,  A61K38/46 ,  G01N33/50 ,  G01N33/60 ,  G01N33/66 ,  G01N33/68 ,  C07K14/715

摘要： The present disclosure provides compositions for regulating glucose metabolism. The compositions provide for reduced levels of p75NTR and/or reduced binding of p75NTR to a GTPase such as Rab31 or Rab5. The compositions are useful in methods of regulating glucose metabolism, which methods are also provided.

公开(公告)号：US10227565B2

公开(公告)日：2019-03-12

申请号：US15361900

申请日：2016-11-28

申请人： The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone ,  The Regents of the University of California

发明人： Saiyong Zhu ,  Sheng Ding ,  Holger Willenbring ,  Milad Rezvani ,  Jack Harbell

IPC分类号： A61K38/18 ,  C12N5/071 ,  A61K31/506 ,  A61K31/661 ,  A61K31/19 ,  A61K31/135 ,  A61K31/405 ,  A61K31/4709 ,  A61K31/573 ,  A61K35/407 ,  A61K45/06

摘要： Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.

公开(公告)号：US10106818B2

公开(公告)日：2018-10-23

申请号：US14910665

申请日：2014-08-14

申请人： THE J. DAVID GLADSTONE INSTITUTES

发明人： Eric M. Verdin ,  Vincenzo Calvanese

IPC分类号： C12N15/86 ,  C12Q1/6897 ,  C12Q1/70 ,  A61K35/17 ,  C12N7/00

摘要： The present disclosure provides for recombinant nucleic acids, and cells and virions comprising the recombinant nucleic acids, that can be used to identify, isolate, and/or purify cells latently infected with immunodeficiency virus. A subject recombinant nucleic acid includes (a) a first nucleotide sequence encoding a first reporter polypeptide that produces a first detectable signal, where the first nucleotide sequence is operably linked to an immunodeficiency virus promoter and is translated as an early gene; and (b) a second nucleotide sequence encoding a second reporter polypeptide that produces a second detectable signal that is distinguishable from the first detectable signal, where the second nucleotide sequence is operably linked to a non-immunodeficiency virus promoter. In some aspects, the first and second nucleotide sequences are both positioned between a shared 5′ long terminal repeat (LTR) and a shared 3′ LTR. Also provided are related methods.

公开(公告)号：US10087151B2

公开(公告)日：2018-10-02

申请号：US15110082

申请日：2015-01-08

申请人： THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE

发明人： Andrey S. Tsvetkov ,  Steven M. Finkbeiner ,  Michael A. Pleiss ,  Robert Greenhouse

IPC分类号： C07D265/36 ,  C07D413/06 ,  C07D498/04 ,  C07D209/08 ,  C07D279/16 ,  C07D279/28 ,  A61K9/02 ,  A61K9/08 ,  A61K9/10 ,  A61K9/20 ,  A61K9/48

摘要： The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.

公开(公告)号：US10004751B2

公开(公告)日：2018-06-26

申请号：US15324561

申请日：2015-07-07

申请人： The J. David Gladstone Institutes ,  The Regents of the University of California

发明人： Melanie Ott ,  Andrew S. Kondratowicz ,  Nevan John Krogan ,  Priya Shirish Shah ,  Krystal Ann Fontaine

IPC分类号： A61K31/5513 ,  A61K9/00 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/444

CPC分类号： A61K31/5513 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/18 ,  A61K31/381 ,  A61K31/444 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61P31/14 ,  Y02A50/385

摘要： The present disclosure provides methods of treating a flavivirus infection, and compositions for use in the methods.