摘要:
A method of delivering a substance to targeted tissue comprising the steps of: delivering a plurality of magnetically responsive particles which are carrying the substance and have a hydrophobic coating into the patient's vasculature upstream of the targeted tissue; and applying a magnetic gradient in the vicinity of the targeted tissue to draw the magnetically responsive particles against the wall of the patient's vasculature in the vicinity of the targeted tissue, to allow the substance on the magnetic particles to migrate through the wall of the patent's vasculature to targeted tissue.
摘要:
Agents containing magnetic particles are suitable for use in enhancing images in diagnostic procedures, e.g., via x-ray, ultrasound or especially NMR. Preferred particles are based on metals, e.g., iron, cobalt or nickel, double metal oxides/hydroxides or complexes thereof.
摘要:
Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise an ethylene vinyl alcohol copolymer, a biocompatible solvent and a water insoluble contrasting agent selected from the group consisting of tantalum, tantalum oxide and barium sulfate. Also disclosed are methods for embolizing a blood vessel using the compositions described herein.
摘要:
A method of contrast enhanced ultrasonic diagnostic imaging comprising: administering to a subject a contrast enhancing amount of spheres or particles comprising a matrix enclosing a contrast agent which reflects sound waves, said matrix being a biocompatible, biodegradable, non-immunogenic non-polyamino acid synthetic polymer; and generating an ultrasonic image of said subject.
摘要:
Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a cellulose diacetate polymer, a biocompatible solvent and a water insoluble contrasting agent selected from the group consisting of tantalum, tantalum oxide and barium sulfate. Also disclosed are methods for embolizing a blood vessel using the compositions described herein.
摘要:
Radiopaque bismuth particles and methods of making and using the radiopaque bismuth particles are disclosed. The radiopaque bismuth particles include an elemental bismuth core and an outer coating comprising one or more coating agents. Disclosed radiopaque bismuth particles are suitable for use in surgical sponges and plastic objects.
摘要:
Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T1/T2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
摘要:
Radiopaque bismuth particles and methods of making and using the radiopaque bismuth particles are disclosed. The radiopaque bismuth particles include an elemental bismuth core and an outer coating comprising one or more coating agents. Disclosed radiopaque bismuth particles are suitable for use in surgical sponges and plastic objects.
摘要:
An imaging system includes a radiation source (110) that emits radiation that traverses an examination region and a detector (116) that detects radiation traversing the examination region and a subject disposed therein, and produces a signal indicative of the energy of the detected radiation. A data selector (122) energy discriminates the signal based on an energy spectra setting corresponding to first and second spectral characteristics of a contrast agent administered to the subject, wherein the contrast agent has a first attenuation spectral characteristic when attached to the target and a second different spectral characteristic when not attached to the target. A reconstructor (134) reconstructs the signal based on the first and second spectral characteristics and generates volumetric image data indicative of the target.
摘要:
A method and a measurement system are disclosed for the noninvasive determination of properties of an object to be examined and to the use of a contrast medium for X-ray phase-contrast measurement. in at least one embodiment of the invention, a mixture (suspension) consisting of a base liquid and a multiplicity of particles contained therein is used, the refractive index of the base liquid being different to the refractive index of the particles.