公开(公告)号：US20170043181A1

公开(公告)日：2017-02-16

申请号：US15266371

申请日：2016-09-15

Applicant: Varian Medical Systems International AG

Inventor： Karl OTTO

IPC: A61N5/10

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods for planning delivery of radiation dose to a target region within a subject comprise: initializing a first plurality of control points located on a trajectory, the trajectory comprising relative movement between a radiation source and the subject, wherein initializing the first plurality of control points comprises assigning, to each the first plurality of control points, one or more axis positions which specify a position of the radiation source relative to the subject; specifying a second plurality of control points along the trajectory, the second plurality of control points comprising a larger number of control points than the first plurality of control points; and iteratively optimizing a stimulated dose distribution over the second plurality of control points to thereby determine a radiation delivery plan by assigning each of the second plurality of control points optimized values for one or more radiation delivery parameters.

Abstract translation: 用于规划对受试者内的目标区域的辐射剂量传递的方法包括：初始化位于轨迹上的第一多个控制点，所述轨迹包括辐射源与所述对象之间的相对运动，其中初始化所述第一多个控制点包括 向所述第一多个控制点中的每一个分配指定所述辐射源相对于所述对象的位置的一个或多个轴位置; 指定沿所述轨迹的第二多个控制点，所述第二多个控制点包括比所述第一多个控制点更大数量的控制点; 以及迭代地优化所述第二多个控制点上的刺激剂量分布，从而通过分配所述第二多个控制点中的每一个来确定一个或多个辐射传递参数的优化值来确定辐射传播计划。

公开(公告)号：US09050459B2

公开(公告)日：2015-06-09

申请号：US14202305

申请日：2014-03-10

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/10

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

Abstract translation: 提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。 在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。 一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。 对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

公开(公告)号：US08847179B2

公开(公告)日：2014-09-30

申请号：US13448553

申请日：2012-04-17

Applicant: Shinichiro Fujitaka ,  Yusuke Fujii ,  Rintaro Fujimoto ,  Kazuo Hiramoto ,  Hiroshi Akiyama

Inventor： Shinichiro Fujitaka ,  Yusuke Fujii ,  Rintaro Fujimoto ,  Kazuo Hiramoto ,  Hiroshi Akiyama

IPC: G21K5/04 ,  A61N5/10

CPC classification number: A61N5/1043 ,  A61N5/1036 ,  A61N5/1045 ,  A61N2005/1087

Abstract: A charged particle beam reduces treatment time in the uniform scanning or in the conformal layer stacking irradiation. In the uniform scanning, an optimum charged particle beam scan path for uniformly irradiating a collimator aperture area is calculated. In the conformal layer stacking irradiation, an optimum charged particle beam scan path for uniformly irradiating a multi-leaf collimator aperture area of each layer for each of the layers obtained by partitioning the target volume is calculated. Alternatively, a minimum irradiation field size that covers the multi-leaf collimator aperture area of each layer is calculated, and a scan path corresponding to the irradiation field size, prestored in a memory of a particle therapy control apparatus, is selected. The charged particle beam scan path is optimally changed in the lateral directions in conformity with the collimator aperture area in the uniform scanning or in each layer in the conformal layer stacking irradiation.

Abstract translation: 带电粒子束在均匀扫描或共形层层叠照射中减少处理时间。 在均匀扫描中，计算用于均匀照射准直器孔径面积的最佳带电粒子束扫描路径。 在保形层堆积照射中，计算用于对通过划分目标体积获得的每个层的各层的多叶准直器孔径面均匀地照射的最佳带电粒子束扫描路径。 或者，计算覆盖各层的多叶准直器开口面积的最小照射场尺寸，并且选择预先存储在粒子治疗控制装置的存储器中的与照射场尺寸对应的扫描路径。 带电粒子束扫描路径在均匀扫描中或在共形层堆积照射中每层中的准直器开口面积在横向上最佳地改变。

公开(公告)号：US08744045B2

公开(公告)日：2014-06-03

申请号：US13676370

申请日：2012-11-14

Applicant: Varian Medical Systems International AG

Inventor： Janne Iimari Nord ,  Tuomas Erik Torsti

IPC: A61N5/10

CPC classification number: A61N5/1047 ,  A61N5/1036 ,  A61N5/1037 ,  G21K1/02 ,  G21K1/043 ,  G21K1/046

Abstract: A method and system for providing intensity modulated radiation therapy to a moving target is disclosed. According to a preferred embodiment of the invention, a treatment plan for providing radiotherapy using a multi-leaf collimator (“MLC”) comprises a plurality of sub-plans, each of which is optimized for a different phase of target movement. Movements of the treatment target are tracked in real time, and the choice of which sub-plan to implement is made in real time based on the tracked position of the target. Each of the sub-plans is preferably formulated to minimize interplay effects between target movements and MLC leaf movements, consistent with other planning goals. In addition, the sub-plans preferably include a predicted region corresponding to the next anticipated position of the target, in order to facilitate the transition to the next position.

Abstract translation: 公开了一种向移动目标提供强度调制辐射治疗的方法和系统。 根据本发明的优选实施例，使用多叶准直器（“MLC”）提供放射治疗的治疗计划包括多个子计划，每个子计划针对目标运动的不同阶段进行了优化。 治疗目标的移动实时跟踪，根据目标的跟踪位置实时选择实施的子计划。 每个子计划优选地被配制为使目标运动和MLC叶运动之间的相互作用效应最小化，与其他规划目标一致。 此外，子方案优选地包括对应于目标的下一个预期位置的预测区域，以便于向下一个位置的转变。

公开(公告)号：US20130187062A1

公开(公告)日：2013-07-25

申请号：US13356835

申请日：2012-01-24

Applicant: Janne NORD ,  Perttu NIEMELÄ ,  Esa KUUSELA

Inventor： Janne NORD ,  Perttu NIEMELÄ ,  Esa KUUSELA

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1031 ,  G06F19/00

Abstract: A control circuit optimizes a radiation-treatment plan to provide an initially-optimized radiation-treatment plan and then modifies that initially-optimized radiation-treatment plan to reduce corresponding monitor units (MU's) to provide a radiation-treatment plan that is further optimized for monitor units. This modification can comprise, at least in part, imposing a stronger smoothing constraint with respect to fluence. Optimizing a radiation-treatment plan to provide an initially-optimized radiation-treatment plan can comprise identifying at least one particular leaf pair for a multi-leaf collimator that requires a longest amount of time to move into a position that achieves a particular desired fluence and then selectively smoothing position requirements of that particular leaf pair to reduce the amount of time associated with that particular leaf pair while not also smoothing position requirements for all leaf pairs as comprise that multi-leaf collimator.

Abstract translation: 控制电路优化辐射治疗计划，以提供初始优化的辐射治疗计划，然后修改最初优化的辐射治疗计划，以减少对应的监测单位（MU），以提供进一步优化的辐射治疗计划 监控单位。 该修改可以至少部分地包括相对于能量密度的更强的平滑约束。 优化辐射处理计划以提供初始优化的辐射处理计划可以包括为多叶准直器识别至少一个特定叶对，其需要最长的时间来移动到达到特定期望通量的位置， 然后选择性地平滑该特定叶对的位置要求，以减少与特定叶对相关联的时间量，而不对包括该多叶准直器的所有叶对的平滑位置要求进行平滑。

公开(公告)号：US20120313002A1

公开(公告)日：2012-12-13

申请号：US13318866

申请日：2011-03-08

Applicant: Masahiro Ikeda ,  Hisashi Harada ,  Osamu Takahashi

Inventor： Masahiro Ikeda ,  Hisashi Harada ,  Osamu Takahashi

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1043 ,  A61N2005/1087

Abstract: A particle beam treatment device includes an irradiation nozzle which moves a particle beam in a direction which is perpendicular to an advancing direction; a dose monitor which measures the dose of the particle beam; a planning part which sets the irradiation dose applied to a target volume; and a controlling part which controls the irradiation dose applied to a target volume based on irradiation dose set value which is set by a value measured by the dose monitor and the planning part, wherein the planning part stores the absorbed dose distribution data in the depth direction which is prepared in advance using the absorbed dose at the reference depth which is a predetermined position nearer to an incident side of the particle beam than the position of Bragg peak as the reference and calculates the irradiation dose set value using the absorbed dose at the reference depth.

Abstract translation: 粒子束处理装置包括使粒子束沿与前进方向正交的方向移动的照射喷嘴; 测量粒子束剂量的剂量监测器; 将照射剂量设定在目标体积上的规划部分; 以及控制部，其基于由所述剂量监视器和所述规划部测量的值设定的照射剂量设定值来控制施加于目标体积的照射剂量，其中，所述规划部将所述吸收剂量分布数据存储在所述深度方向 其预先使用在比布拉格峰位置作为基准更靠近粒子束的入射侧的预定位置处的参考深度处的吸收剂量来计算，并且使用参考的吸收剂量来计算照射剂量设定值 深度。

公开(公告)号：US08295436B2

公开(公告)日：2012-10-23

申请号：US12879165

申请日：2010-09-10

Applicant: Janne Nord ,  Jarkko Peltola

Inventor： Janne Nord ,  Jarkko Peltola

IPC: A61N5/10

CPC classification number: A61N5/1036

Abstract: Determine first information regarding physical-movement limitations pertaining to at least one multi-leaf collimator and also determine second information regarding movement of the treatment target with respect to the given patient. Then, while optimizing a radiation-treatment leaf-sequence plan, constrain individually-planned leaf positions as a function, at least in part, of the first information, the second information, and planned positions of adjacent leaves. By one approach, the first information can comprise information regarding a speed (such as a maximum speed) at which individual leaves of the multi-leaf collimator are able to move during a treatment session. By one approach, the second information can comprise information regarding a distance (such as a maximum distance) that one or more parts of the treatment target may possibly move as compared to a presumed position used during the optimizing of the radiation-treatment leaf-sequence plan.

Abstract translation: 确定关于至少一个多叶准直器的身体运动限制的第一信息，并且还确定关于治疗目标相对于给定患者的运动的第二信息。 然后，在优化辐射处理叶序列计划的同时，至少部分地限制相邻叶片的第一信息，第二信息和计划位置的单独计划的叶位置。 通过一种方法，第一信息可以包括关于多叶准直器的各个叶片在治疗期间能够移动的速度（例如最大速度）的信息。 通过一种方法，第二信息可以包括关于治疗目标的一个或多个部分可能移动的距离（例如最大距离）的信息，与在放射治疗叶序列的优化期间使用的推定位置相比 计划。

公开(公告)号：US20110200170A1

公开(公告)日：2011-08-18

申请号：US12708141

申请日：2010-02-18

Applicant: Janne Ilmari Nord ,  Tuomas Erik Torsti

Inventor： Janne Ilmari Nord ,  Tuomas Erik Torsti

IPC: A61N5/10 ,  G21K1/04

CPC classification number: A61N5/1047 ,  A61N5/1036 ,  A61N5/1037 ,  G21K1/02 ,  G21K1/043 ,  G21K1/046

Abstract: A method and system for providing intensity modulated radiation therapy to a moving target is disclosed. According to a preferred embodiment of the invention, a treatment plan for providing radiotherapy using a multi-leaf collimator (“MLC”) comprises a plurality of sub-plans, each of which is optimized for a different phase of target movement. Movements of the treatment target are tracked in real time, and the choice of which sub-plan to implement is made in real time based on the tracked position of the target. Each of the sub-plans is preferably formulated to minimize interplay effects between target movements and MLC leaf movements, consistent with other planning goals. In addition, the sub-plans preferably include a predicted region corresponding to the next anticipated position of the target, in order to facilitate the transition to the next position.

Abstract translation: 公开了一种向移动目标提供强度调制辐射治疗的方法和系统。 根据本发明的优选实施例，使用多叶准直器（“MLC”）提供放射治疗的治疗计划包括多个子计划，每个子计划针对目标运动的不同阶段进行了优化。 治疗目标的移动实时跟踪，根据目标的跟踪位置实时选择实施的子计划。 每个子计划优选地被配制为使目标运动和MLC叶运动之间的相互作用效应最小化，与其他规划目标一致。 此外，子方案优选地包括对应于目标的下一个预期位置的预测区域，以便于向下一个位置的转变。

公开(公告)号：US20110110492A1

公开(公告)日：2011-05-12

申请号：US12986420

申请日：2011-01-07

Applicant: Karl OTTO

Inventor： Karl OTTO

IPC: A61N5/10

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

公开(公告)号：US20110081002A1

公开(公告)日：2011-04-07

申请号：US12947643

申请日：2010-11-16

Applicant: Paul J. Keall ,  Yelin Suh ,  Elisabeth Weiss

Inventor： Paul J. Keall ,  Yelin Suh ,  Elisabeth Weiss

IPC: A61N5/10

CPC classification number: A61N5/1042 ,  A61N5/1036 ,  A61N5/1037

Abstract: A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.

Abstract translation: 公开了一种可交付的四维（4D）强度调制放射治疗（IMRT）规划方法，用于使用具有动态多叶准直器（DMLC）的线性加速器的传送。 4D计算机断层扫描（CT）扫描用于在肿瘤周期性运动的参考期分割肿瘤解剖。 4D CT数据的变形注册用于在其他阶段产生相应的解剖结构。 优选地，根据给定束位置的二维（2D）投影确定，使用与肿瘤的周期性运动相对应的总肿瘤体积（GTV）质心运动来对准每个束位置的准直器。 在4D CT图像集上创建可交付的IMRT计划，其中MLC叶位置和束开/关状态可以通过解决四维优化问题作为呼吸相位的函数而变化。 MLC叶片的机械约束包括在优化中。