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    Method for biologically monitoring the environment (variants) and a system for carrying out said method
    13.
    发明申请
    Method for biologically monitoring the environment (variants) and a system for carrying out said method 有权

    公开(公告)号：US20110028849A1

    公开(公告)日：2011-02-03

    申请号：US12308040

    申请日：2007-06-15

    申请人： Sergei Viktorovich Kholodkevich ,  Alekesi Valentinovich Ivanov ,  Evgeny-Leonidovich Kornienko ,  Anton Sergeevich Kurakin

    发明人： Sergei Viktorovich Kholodkevich ,  Alekesi Valentinovich Ivanov ,  Evgeny-Leonidovich Kornienko ,  Anton Sergeevich Kurakin

    IPC分类号： A61B6/00 ,  G06F19/00 ,  G06F17/18

    CPC分类号： G01N21/359 ,  G01N33/186

    摘要： The invention relates to the field of environment conservation, in particular, to methods and means of ecological environment monitoring with the help of a non-invasive control of functional state of native animals. The invention can predominantly be used for automatic on-line estimation of environment quality on the basis of remote real-time registration of cardiac activity in invertebrates with a hard outer covering.The method includes placing the test invertebrate in the environment under investigation, exposing it to IR optical radiation with the help of a transmitting optical fibre with the output end placed on its hard outer covering within its heart area and an optical radiation source being in optical contact with the input end of the transmitting optical fibre; receiving the reflected optical radiation with the help of the receiving optical fibre with its input end placed on the test invertebrate's hard outer covering within its heart area; converting it to an electrical signal with the help of the optical radiation receiver being in optical contact with the output end of the receiving optical fibre; amplifying the signal obtained; converting its instantaneous values to digital codes; entering them to the computer; making digital filtration of digital codes which is matched to the signal's shape and frequency; determining and memorizing the sample of values of the electrical signal period; determining a sample dispersion or arithmetical mean of difference moduli for each two, closest by the time of obtaining, sample values of the electrical signal period; and forming an ecological danger signal when the threshold value exceeds the sample dispersion of values of the electrical signal period or arithmetical mean of difference moduli for each two, closest by the time of obtaining, sample values of the electrical signal period.The system contains a computer and at least one shaper of the digital signal of cardiac activity in the form of series-connected cardiac activity sensor including a casing with an element for installing on the test invertebrate's body with a hard outer covering, a transmitting optical fibre and receiving optical fibre, an optical radiation source and optical radiation receiver; an amplifier and analog-to-digital converter whose output is connected to the computer input. The input end of the transmitting optical fibre and output end of the receiving optical fibre are secured so that they can have optical contact with, respectively, the optical radiation source and optical radiation receiver, and the output end of the transmitting optical fibre and input end of the receiving optical fibre face one side and are positioned in the casing at a distance satisfying the inequality (πd2P)0.07−2.2(1/(πd2P))0.02≦R≦(πd2P)0.07+2.2(1/(πd2P))0.02, where R—distance between the output end of the transmitting optical fibre and input end of the receiving optical fibre, mm; P—output power of the optical radiation source, mW; d—diameter of the transmitting optical fibre or receiving optical fibre, μm.The invention provides a higher reliability of environment monitoring, widening of functional potentials, as well as lower cost and simpler operation of the system for biological environment monitoring.

    METHOD OF DETERMINING THE EFFECT OF A SPILL ON A MARINE ENVIRONMENT
    14.
    发明申请
    METHOD OF DETERMINING THE EFFECT OF A SPILL ON A MARINE ENVIRONMENT 有权
    确定泄漏对海洋环境的影响的方法

    公开(公告)号：US20090226373A1

    公开(公告)日：2009-09-10

    申请号：US12162342

    申请日：2007-01-23

    申请人： Odd Kjetil Andersen ,  Steinar Sanni

    发明人： Odd Kjetil Andersen ,  Steinar Sanni

    IPC分类号： A61K49/00

    CPC分类号： G01N33/186 ,  G01N33/1886 ,  Y10T436/12 ,  Y10T436/21

    摘要： A method of determining the effect of a spill on a marine environment, in which physical and chemical sensors are arranged with living organisms (4, 6) fitted with instruments, at an appropriate distance and position from the object (1) which is to be monitored, wherein the response of the living organism (4, 6), measured online in real time, is compared with known patterns of response, and where upstream and downstream measurements are compared to determine whether a change in response may be caused by a spill from the object, the significance of the real time measurements being validated through sampling of the organisms on a regular basis or as required, in order to analyze the effects on the health of the organisms, biomarkers, for the purpose of assessing the significance of the environmental effect.

    摘要翻译： 确定泄漏对海洋环境的影响的方法，其中物理和化学传感器与装有仪器的活生物体（4,6）排列在与物体（1）相适应的距离和位置 监测，其中实时在线测量的生物体（4,6）的响应与已知的响应模式进行比较，并且在比较上游和下游测量值以确定响应变化是否可能由溢出引起的 从目标来看，实时测量的重要性通过定期或根据需要对生物进行抽样来验证，以便分析对生物体，生物标志物的健康的影响，以评估生物体的重要性 环境影响。

    Submersible Portable In-situ Automated Water Quality Biomonitoring Apparatus and Method
    15.
    发明申请
    Submersible Portable In-situ Automated Water Quality Biomonitoring Apparatus and Method 失效
    潜水便携式现场自动化水质生物监测仪器及方法

    公开(公告)号：US20080262739A1

    公开(公告)日：2008-10-23

    申请号：US11736437

    申请日：2007-04-17

    申请人： Mark W. Widder ,  Tommy R. Shedd ,  Mark W. Brown ,  Murray S. Swanson

    发明人： Mark W. Widder ,  Tommy R. Shedd ,  Mark W. Brown ,  Murray S. Swanson

    IPC分类号： G06F19/00

    CPC分类号： G01N33/186 ,  G01N33/1886

    摘要： A submersible biomonitoring system for monitoring water quality in situ includes a submersible chamber constructed of a di-electric material and sized to allow suitable signals from one or more aquatic organisms to be received by eliminating cross-talk between cells while allowing ambient conditions to be maintained inside the chamber. The aquatic organism exhibits ventilatory behavior and body movement sensitive to water quality which manifest as electrical signals picked up by electrodes and communicated to a pre-amplifier that conditions the signals for communication to a land-based amplifier and/or controller that is used to interpret the signals to determine when the water to which the organism is exposed has caused physiological stress to the organism.

    摘要翻译： 用于原位监测水质的潜水生物监测系统包括由二电材料构成的潜水室，其尺寸允许通过消除电池之间的串扰同时允许保持环境条件来接收来自一个或多个水生生物的适当信号 在房间里面 水生生物表现出对水质敏感的通气行为和身体运动，其表现为电极拾取的电信号，并传达到前置放大器，该前置放大器控制用于与用于解释的陆基放大器和/或控制器通信的信号 确定生物暴露于水何时的信号已经对生物体产生生理压力。

    High estrogen-sensitive medaka fish
    16.
    发明授权
    High estrogen-sensitive medaka fish 失效
    高雌激素敏感的med鱼

    公开(公告)号：US06759568B2

    公开(公告)日：2004-07-06

    申请号：US09893666

    申请日：2001-06-29

    申请人： Ichiro Yamashita

    发明人： Ichiro Yamashita

    IPC分类号： G01N3300

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/40 ,  A01K2267/03 ,  C07K14/461 ,  G01N33/186 ,  G01N33/5082 ,  G01N33/74 ,  G01N2520/00

    摘要： (1) Transgenic medaka fish into which a polynucleotide having the nucleotide sequence from 211 to 1935 position represented by Sequence ID No: 1 is introduced, (2) A method of producing medaka fish having one or more thrombi, comprising the step of raising the transgenic medaka fish described in (1) in the presence of estrogen, (3) Medaka fish having one or more thrombi produced by the method described in (2), and (4) A method of testing an estrogen-like acting substance, comprising the steps of raising the transgenic medaka fish described in (1) in test water, and observing whether or not one or more thrombi are formed in the medaka fish after the raising step.

    摘要翻译： （1）引入具有由序列号1表示的211〜1935位置的碱基序列的多核苷酸的转基因aka鱼，（2）一种制备具有一个或多个血栓的aka鱼的方法，其包括： （1）中描述的在雌激素存在下的转基因aka鱼，（3）通过（2）中描述的方法制备的具有一种或多种血栓的楝树鱼，和（4）一种测试雌激素样作用物质的方法，包括 （1）中描述的转基因aka鱼在试验水中的步骤，并且观察在升高步骤之后是否在aka鱼中形成一个或多个血栓。

    Nectophotometer
    17.
    发明授权
    Nectophotometer 失效

    公开(公告)号：US5916801A

    公开(公告)日：1999-06-29

    申请号：US960529

    申请日：1997-10-31

    申请人： Richard William LoPinto ,  John Christopher Santelli

    发明人： Richard William LoPinto ,  John Christopher Santelli

    IPC分类号： G01N33/18 ,  C12M1/34 ,  C12Q1/20

    CPC分类号： G01N33/186

    摘要： A computer interfaced device for rapidly quantifying levels of toxicity to small aquatic organisms in aqueous environments. The device has a plurality of test chambers containing replicates of a plurality of concentrations of a substance or sample being tested for toxicity. Each chamber also contains a predetermined number of motile aquatic organisms. Light originating on one side of each test chamber is received by a photo-detector on the opposite side. The device's sensitivity is adjusted so that each interruption of a light beam caused by movement of a test organism in each test chamber is recorded for that chamber. Using this device and a toxicity testing protocol both lethality and changes in the frequency of test organism's movement in each concentration of substance or sample is monitored. Toxicity is by convention quantified as the concentration of a substance or sample which causes a predetermined level of lethal or sublethal response usually after a plurality of days. Using simple statistical software, the level of lethality which will occur following a plurality of days of exposure to each concentration can be predicted from motility data generated within just a few hours (usually 2.5 Hours) of exposing test organisms to the substance or sample. The computer includes software responsive to light beam interruption for deriving a set of parameters useful for predicting lethality. The device and accompanying software permits toxicity of a substance or sample to be quantified rapidly from motility data, long before lethality occurs.

    摘要翻译： 一种计算机接口装置，用于在水环境中快速量化对小水生生物的毒性水平。 该装置具有多个测试室，其包含多个浓度的待测物质或样品的毒性的重复。 每个室还含有预定数量的活动水生生物。 在每个测试室的一侧产生的光由相对侧的光电检测器接收。 调整设备的灵敏度，以便记录每个测试室中的测试生物体的移动引起的光束的每次中断。 使用该设备和毒性测试方案，监测每种浓度物质或样品中测试生物运动频率的致死率和变化。 按照惯例将毒性定量为通常在多天后引起预定水平的致死或亚致死反应的物质或样品的浓度。 使用简单的统计软件，可以在将测试生物体暴露于物质或样品的短短几个小时（通常为2.5小时）内产生的运动数据来预测在每个浓度暴露多天后将发生的致死率水平。 计算机包括响应于光束中断的软件，用于得出用于预测致死率的一组参数。 该设备和随附的软件允许物质或样品的毒性从致死性数据快速量化，在致死性发生之前。

    Method and apparatus for monitoring aqueous media using electrolocating aquatic animals
    18.
    发明授权
    Method and apparatus for monitoring aqueous media using electrolocating aquatic animals 失效
    使用电定位水生动物监测含水介质的方法和装置

    公开(公告)号：US5804705A

    公开(公告)日：1998-09-08

    申请号：US648156

    申请日：1996-07-11

    申请人： Andre Florion ,  Denis Terver ,  Didier Cretien ,  Marielle Thomas

    发明人： Andre Florion ,  Denis Terver ,  Didier Cretien ,  Marielle Thomas

    IPC分类号： G01N33/18 ,  G01N33/00 ,  A01K63/00

    CPC分类号： G01N33/186

    摘要： Aquatic animals that emit electrical signals are used to detect changes in the operating conditions of an aqueous medium (e.g., the presence of a pollutant). In one embodiment, the aquatic test animals are fishes of a species known as Apteronotus albifrons, whose electrical signals have frequency variations on the order of 0.1% under constant operating conditions; the temperature of the aqueous medium is stabilized to within 0.1.degree. C.; each aquatic test animal is placed in a perforated refuge within a holding tank in which the aqueous medium flows in a vertical direction; and three or more aquatic test animals are used, wherein phases of nychthemeral activity of the aquatic test animals are artificially offset to achieve overlapping of the nychthemeral activity of the aquatic test animals. All of these combine to yield a highly sensitive and reliable system for real-time biological monitoring of physico-chemical parameters of an aqueous medium.

    摘要翻译： PCT No.PCT / FR94 / 01346 Sec。 371日期：1996年7月11日 102（e）日期1996年7月11日PCT 1994年11月18日PCT PCT。 出版物WO95 / 14925 日期1995年6月1日发射电信号的动物用于检测水性介质的操作条件的变化（例如，污染物的存在）。 在一个实施方案中，水生试验动物是称为Apteronotus albifron的物种的鱼，其电信号在恒定操作条件下具有约0.1％的频率变化; 水介质的温度稳定在0.1℃以内。 将每个水生试验动物放置在容纳槽内的穿孔避难所，其中水介质在垂直方向上流动; 并且使用三种或更多种水生试验动物，其中水生试验动物的潜伏活动的相被人为地抵消以实现水生试验动物的ch活动的重叠。 所有这些结合起来产生了一种高灵敏度和可靠性的系统，用于水性介质的物理化学参数的实时生物监测。

    Continuous monitoring of water quality
    20.
    发明授权
    Continuous monitoring of water quality 失效
    持续监测水质

    公开(公告)号：US4723511A

    公开(公告)日：1988-02-09

    申请号：US721436

    申请日：1985-04-08

    申请人： Arthur J. Solman ,  Graham P. Evans

    发明人： Arthur J. Solman ,  Graham P. Evans

    IPC分类号： G01N27/06 ,  G01N33/18 ,  A01K61/00

    CPC分类号： G01N33/186

    摘要： A supply of water is continuously monitored to ensure purtiy by dividing the supply into a number of parallel streams and flowing each through a fish tank containing a fish (or other aquatic animal), the health of each fish being monitored by electrodes in each respective tank. The fish tanks are located together in a main tank and the water supply is drawn from a header tank via pipework, the tank being fed from supply. The apparatus includes an electronic system to monitor the activity of the fish.

    摘要翻译： 通过将供水分成若干个平行的河流，并通过一条含有鱼类（或其他水生动物）的鱼缸将水供应连续监测，以便每个相应罐中的电极监测每条鱼的健康状况 。 鱼缸位于主箱中，​​水管通过管道从集水箱中抽出，水箱由供水供给。 该装置包括用于监测鱼的活动的电子系统。