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    MECHANISM FOR A DRUG DELIVERY DEVICE
    12.
    发明申请
    MECHANISM FOR A DRUG DELIVERY DEVICE 审中-公开
    药物递送装置的机制

    公开(公告)号：US20160184533A1

    公开(公告)日：2016-06-30

    申请号：US14892308

    申请日：2014-04-26

    申请人： SANOFI SA

    发明人： Stefan MAYER

    IPC分类号： A61M5/50 ,  A61M15/00 ,  A61M5/315

    CPC分类号： A61M5/50 ,  A61M5/31533 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/0078 ,  A61M15/0081 ,  A61M2202/064 ,  A61M2205/273 ,  G06M1/246 ,  G06M3/02

    摘要： A mechanism for a drug delivery device, having a first and a second state, including an engagement preventing member, and a blocking member having a blocking feature and an engagement element which is engagable with the blocking member. The blocking member is configured to engage with the engagement element in a non-linear movement, thereby moving the blocking feature is moved from a first position to a second position in an arc shaped movement. In the first state of the mechanism, the engagement preventing member is configured to prevent an engagement of the blocking member with the engagement element by covering the engagement element, and wherein, in the second state of the mechanism, the engagement element is free from the engagement preventing member such that the blocking member is enabled to engage with the engagement element.

    摘要翻译： 具有第一和第二状态的药物输送装置的机构，包括接合防止构件，以及具有阻塞特征的阻挡构件和与阻挡构件接合的接合元件。 阻挡构件构造成以非线性运动与接合元件接合，从而使阻挡特征从弧形移动中的第一位置移动到第二位置。 在机构的第一状态下，接合防止构件被构造成通过覆盖接合元件来防止阻挡构件与接合元件的接合，并且其中，在机构的第二状态中，接合元件没有 接合防止构件，使得阻挡构件能够与接合元件接合。

    De-agglomerator for breath-actuated dry powder inhaler
    17.
    发明授权
    De-agglomerator for breath-actuated dry powder inhaler 有权
    用于呼吸干粉吸入器的脱附器

    公开(公告)号：US06871646B2

    公开(公告)日：2005-03-29

    申请号：US10837004

    申请日：2004-04-30

    申请人： Laurence Keane ,  David O'Leary

    发明人： Laurence Keane ,  David O'Leary

    IPC分类号： A61M15/00 ,  G06M1/24 ,  A65D83/06 ,  A61M15/08 ,  A61M16/00

    CPC分类号： A61M15/0086 ,  A61M15/0008 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0068 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2206/16 ,  G06M1/246

    摘要： A de-agglomerator is provided for use with a breath-actuated dry powder inhaler for breaking up aggregates and micronizing particles of dry powder prior to inhalation of the powder by a patient using the inhaler. The de-agglomerator includes an inner wall defining a swirl chamber extending along an axis from a first end to a second end, a dry powder supply port, an inlet port, and an outlet port. The supply port is in the first end of the swirl chamber for providing fluid communication between a dry powder delivery passageway of an inhaler and the first end of the swirl chamber. The inlet port is in the inner wall of the swirl chamber adjacent to the first end of the swirl chamber and provides fluid communication between a region exterior to the de-agglomerator and the swirl chamber. The outlet port provides fluid communication between the second end of the swirl chamber and a region exterior to the de-agglomerator, whereby a breath induced low pressure at the outlet port causes air flows into the swirl chamber through the dry powder supply port and the inlet port. The air flows collide with each other and with the wall of the swirl chamber prior to exiting through the outlet port, such that any powder entrained in the air flows is broken down and micronized. The de-agglomerator further includes vanes at the first end of the swirl chamber for creating additional collisions and impacts of entrained powder.

    摘要翻译： 提供去聚集器用于呼吸致动的干粉吸入器，用于在使用吸入器的患者吸入粉末之前破碎聚集体并粉碎干粉颗粒。 除凝器包括限定从第一端延伸到第二端的旋转室的内壁，干粉供给口，入口端口和出口。 供应口位于涡流室的第一端，用于在吸入器的干粉输送通道和涡流室的第一端之间提供流体连通。 入口位于涡流室的内壁中，与涡旋室的第一端相邻，并且在去附聚器外部的区域与涡流室之间提供流体连通。 出口端口提供涡流室的第二端和去附聚器外部的区域之间的流体连通，由此在出口处的呼吸引起的低压使空气通过干粉供给口和入口进入涡流室 港口。 空气流在离开出口之前相互碰撞并与涡流室的壁碰撞，使得夹带在空气流中的任何粉末被分解并微粉化。 除凝器还包括在涡流室的第一端处的叶片，用于产生夹带的粉末的附加碰撞和撞击。

    Inhaler dose counter
    18.
    发明授权
    Inhaler dose counter 有权
    吸入剂量计数器

    公开(公告)号：US06446627B1

    公开(公告)日：2002-09-10

    申请号：US09319947

    申请日：1999-10-22

    申请人： Nicholas John Bowman ,  Michael John Holroyd ,  Costaninos Panayi ,  William Richard Treneman

    发明人： Nicholas John Bowman ,  Michael John Holroyd ,  Costaninos Panayi ,  William Richard Treneman

    IPC分类号： A61M1100

    CPC分类号： A61M15/009 ,  A61M15/0068 ,  A61M15/0078 ,  G06M1/083 ,  G06M1/22 ,  G06M1/246

    摘要： A dose counter for a metered dose inhaler comprises actuator means (341), drive means (350) for driving a rotary gear (360) in step-wise fashion in response to displacement of said actuator means (341), said rotary gear (360) comprising a wheel having a plurality of ratchet teeth (not shown) around its periphery. Means (364) are provided to prevent reverse rotation of the rotary gear (360). A flexible tape (368) is provided with a visible array of incrementing integers on its surface indicating the number of medicament doses remaining in the inhaler. The tape (368) indexes by a single integer in response to each step of the step-wise rotary motion of the rotary gear (360). A control surface (371) regulates the position of engagement and disengagement between the drive means (350) and the rotary gear (360). In an alternative embodiment (FIG. 6), the control surface (371) is omitted and the means for preventing reverse rotation comprise a stepless restraint (664).

    摘要翻译： 用于计量剂量吸入器的剂量计数器包括致动器装置（341），用于响应于所述致动器装置（341）的位移而逐步地驱动旋转齿轮（360）的驱动装置（350），所述旋转齿轮（360） ）包括围绕其周边具有多个棘轮齿（未示出）的轮。 提供装置（364）以防止旋转齿轮（360）的反向旋转。 柔性带（368）在其表面上设置有可见的递增整数阵列，指示吸入器中剩余的药物剂量的数量。 响应于旋转齿轮（360）的逐步旋转运动的每个步骤，带（368）由单个整数索引。 控制表面（371）调节驱动装置（350）和旋转齿轮（360）之间的接合和分离的位置。 在替代实施例（图6）中，省略了控制表面（371），并且用于防止反向旋转的装置包括无级限制（664）。

    Dose indicating device
    19.
    发明授权
    Dose indicating device 失效
    剂量指示装置

    公开(公告)号：US6076521A

    公开(公告)日：2000-06-20

    申请号：US652555

    申请日：1996-06-07

    申请人： Jan-Eric Lindahl ,  Kjell Wetterlin

    发明人： Jan-Eric Lindahl ,  Kjell Wetterlin

    IPC分类号： A61J7/00 ,  A61M15/00 ,  G06M1/24

    CPC分类号： G06M1/246 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/0078 ,  A61M15/008 ,  A61M2202/064 ,  A61M2205/52

    摘要： A dose indicating device constructed for use with an inhalator is disclosed. The inhalator contains multiple doses of a medicament and has an operational portion that includes a dosing unit defining an inhalation channel, and a maneuvering element. The maneuvering element loads a dose of the medicament to the dosing unit and provides the dose in a position in the inhalation channel for inhalation. The dose indicating device includes: a body constructed to be mounted on the maneuvering element of the inhalator; a first element constructed to be mounted on and around an outer wall surface of the maneuvering element; a second element rotatably mounted on and around the outer surface of the first element for rotation relative to the first element; corresponding portions provided on the first and second elements constructed to engage when the inhalator is activated for inhalation in a manner to limit relative movement between the first and second elements; and an indicator constructed to detect movement of the maneuvering element and indicate to a user of the inhalator that a dose has been fed to the inhalation channel when the inhalator is activated for inhalation.

    摘要翻译： PCT No.PCT / SE95 / 01426 Sec。 371日期1996年6月7日第 102（e）日期1996年6月7日PCT提交1995年11月29日PCT公布。 公开号WO96 / 16687 日期1996年6月6日公开了一种构建用于吸入器的剂量指示装置。 吸入器包含多剂量的药物，并且具有操作部分，其包括定义吸入通道的计量单元和操纵元件。 机动元件将一定剂量的药物加载到计量单元，并将剂量提供在吸入通道中用于吸入的位置。 剂量指示装置包括：构造成安装在吸入器的操纵元件上的主体; 构造成安装在所述机动元件的外壁表面上和周围的第一元件; 可旋转地安装在第一元件的外表面上并围绕第一元件的外表面相对于第一元件旋转的第二元件; 设置在第一和第二元件上的相应部分构造成当吸入器被激活以吸入以限制第一和第二元件之间的相对运动的方式接合时; 以及指示器，其构造成用于检测机动元件的运动并且向吸入器的使用者指示当吸入器被激活用于吸入时已经将剂量输送到吸入通道。