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152 条记录 (耗时 0.014 秒)

    Method for preparing opipramol
    11.
    发明授权
    Method for preparing opipramol 失效
    制备opipramol的方法

    公开(公告)号：US5599929A

    公开(公告)日：1997-02-04

    申请号：US336837

    申请日：1994-11-09

    申请人： Daniella Gutman ,  Mishel Ashkar

    发明人： Daniella Gutman ,  Mishel Ashkar

    IPC分类号： C07D223/22 ,  C07D223/26 ,  C07D223/24 ,  C07D403/06

    CPC分类号： C07D223/26 ,  C07D223/22

    摘要： An improved method for preparing opipramol (I) is disclosed, wherein iminostilbene (II) is reacted with 1-bromo-3-chloropropane in the presence of a weak base selected from a hydrogen phosphate salt and an acetate salt and in the presence of a phase transfer agent to produce N-(3-halopropyl)iminostilbene (III), which is mixture of N-(3-chloropropyl)iminostilbene and N-(3-bromopropyl)iminostilbene, and then N-(3-halopropyl)iminostilbene is reacted with N-(2-hydroxyethyl)piperazine to form opipramol, as shown in the following equations, where X is chlorine or bromine. ##STR1##

    摘要翻译： 公开了一种制备奥美拉莫（I）的改进方法，其中亚氨基茋（II）在1-碱金属络合物的存在下，在选自磷酸氢盐和乙酸盐的弱碱的存在下，与1-溴-3-氯丙烷反应， 相转移剂生产N-（3-氯丙基）亚氨基芪和N-（3-溴丙基）亚氨基芪的混合物N-（3-卤代丙基）亚氨基芪（III），然后N-（3-卤代丙基）亚氨基芪 与N-（2-羟乙基）哌嗪反应以形成吡哆醇，如下式所示，其中X为氯或溴。 +图像

    Preparation of asymmetric iminodibenzyl compounds
    13.
    发明授权
    Preparation of asymmetric iminodibenzyl compounds 失效
    不对称氨基苯甲酸化合物的制备

    公开(公告)号：US4013639A

    公开(公告)日：1977-03-22

    申请号：US382120

    申请日：1973-07-24

    申请人： Ryoichi Kitamura ,  Eiichi Kitamura ,  Tetsuo Kitamura ,  Tameo Kitamura

    发明人： Ryoichi Kitamura ,  Eiichi Kitamura ,  Tetsuo Kitamura ,  Tameo Kitamura

    IPC分类号： C07D223/22 ,  C07D223/28

    CPC分类号： C07D223/22

    摘要： Iminodibenzyl derivatives of the formula: ##SPC1##Wherein R and R.sup.1 each represent hydrogen, halogen, amino, sulfamoyl, lower alkyl, lower alkoxy or lower alkanoyl, provided that R and R.sup.1 can not both be hydrogen and when R and R.sup.1 are the same, they are located at positions asymmetric to each other, are produced in high purity and yield by a series of reactions which proceed through novel 2,2'-dinitrostilbene or 2,2'-diaminostilbene and 2,2'-diaminodibenzyl derivatives. The reaction sequence involves condensation, reduction and ring-closure reactions to give asymmetric as well as symmetric iminodibenzyl derivatives. The resulting iminodibenzyl derivatives may be converted to useful pharmaceutical compounds having anti-depressant, analgesic or anti-allergic properties.

    Methyl(9-methyl-acaidan-9-yl)-ketones
    16.
    发明授权
    Methyl(9-methyl-acaidan-9-yl)-ketones 失效
    甲基（9-甲基 - 异佛尔烷基-9-基） - 酮

    公开(公告)号：US3917603A

    公开(公告)日：1975-11-04

    申请号：US32118373

    申请日：1973-01-05

    申请人： CIBA GEIGY CORP

    发明人： GOSTELI JACQUES

    IPC分类号： C07D219/06 ,  C07D223/22 ,  C07D223/28 ,  C07D219/04

    CPC分类号： C07D223/28 ,  C07D219/06 ,  C07D223/22

    摘要： A new process for the production of 10,11-dimethyl-5H-dibenz(b, f)azepines and 5,10,11-trimethyl-5H-dibenz(b,f)azepines as well as their 2- or 3- substituted derivatives comprises the following reaction steps: Condensation of a 9-methyl acridine with acetaldehyde, reduction of the obtained ketone to the corresponding secondary alcohol, followed by WAGNER-MEERWEIN rearrangement to the corresponding 10,11-dimethyl-5H-dibenz(b,f)azepine; illustrative embodiments are 10,11-dimethyl-5H-dibenz(b,f)azepine and 3-trifluoromethyl10,11-dimethyl-5H-dibenz(b,f)azepine.

    摘要翻译： 制备10,11-二甲基-5H-二苯并[b，f]吖庚因和5,10,11-三甲基-5H-二苯并[b，f]吖庚因以及它们的2-或3-取代的新方法 衍生物包括以下反应步骤：

    Derivatives of dibenzo(b f)pyrrolo(3 4-d)azepine
    18.
    发明授权
    Derivatives of dibenzo(b f)pyrrolo(3 4-d)azepine 失效
    二苯酮（B F）吡咯烷（3 4-D）唑烷的衍生物

    公开(公告)号：US3636046A

    公开(公告)日：1972-01-18

    申请号：US3636046D

    申请日：1969-11-19

    申请人： CIBA GEIGY CORP

    发明人： BLATTNER HANS ,  SCHINDLER WALTER ,  GYSIN HERR DR LEONHARD

    IPC分类号： C07D223/22 ,  C07D487/04 ,  C07D27/36

    CPC分类号： C07D223/22 ,  C07D487/04

    摘要： COMPOUNDS OF THE CLASS OF 1,2,3,8-TETRAHYDRO-DIBENZO (B,F)PYRROLO(3,4-D)JAZEPINES AND PHARMACEUITALLY ACCEPTABLE ACID ADDITION SALTS THEREOF HAVE A DEPRESSANT EFFECT ON THE CENTRAL NERVOUS SYSTEM; THEY CAN BE PREPARED FROM N-SUBSTITUTED 10,11-BIS-BROMOMETHYL-5HDIBENZ (B,F)AZEPINES AND A PRIMARY AMINE; THE COMPOUNDS ARE ACTIVE INGREDIENTS OF PHARMACEUTICAL COMPOSITIONS; AN ILLUSTRATIVE EMBODIMENT IS 2-ETHYL-1,2,3,9-TETRAHYDRODIBENZO(3,4-D)JAZEPINE.