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    Resist composition, method of forming resist pattern, and new compound
    5.
    发明授权
    Resist composition, method of forming resist pattern, and new compound 有权
    抗蚀剂组合物，形成抗蚀剂图案的方法和新化合物

    公开(公告)号：US08846291B2

    公开(公告)日：2014-09-30

    申请号：US13312013

    申请日：2011-12-06

    申请人： Yoshiyuki Utsumi ,  Kenichiro Miyashita ,  Akiya Kawaue

    发明人： Yoshiyuki Utsumi ,  Kenichiro Miyashita ,  Akiya Kawaue

    IPC分类号： G03F7/004 ,  C07C303/32 ,  C07C309/07 ,  C07D213/79 ,  C07D213/80 ,  C07D215/48 ,  C07D215/50 ,  C07D215/54 ,  C07D219/04 ,  C07D221/10 ,  G03F7/039

    CPC分类号： C07D213/79 ,  C07D213/80 ,  C07D215/48 ,  C07D215/50 ,  C07D215/54 ,  C07D219/04 ,  C07D221/10 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/039 ,  G03F7/0397 ,  Y10S430/121 ,  Y10S430/122 ,  Y10S430/123

    摘要： A resist composition including: a base component (A) which exhibits changed solubility in a developing solution under action of acid; a nitrogen-containing organic compound component (C) containing a compound (C1) represented by general formula (c1) shown below; and an acid generator component (B) which generates acid upon exposure, provided that the compound (C1) is excluded from the acid generator component (B): wherein RN represents a nitrogen-containing heterocyclic group which may have a substituent; X0 represents a linear or branched divalent aliphatic hydrocarbon group of 1 to 10 carbon atoms, a cyclic divalent aliphatic hydrocarbon group of 3 to 20 carbon atoms or a divalent aliphatic hydrocarbon group of 3 to 20 carbon having a cyclic partial structure, or any one of these groups in which some or all of the hydrogen atoms thereof have been substituted with fluorine atoms; and M+ represents an organic cation.

    摘要翻译： 一种抗蚀剂组合物，其包含：在酸的作用下在显影液中表现出改变的溶解度的碱成分（A） 含有下述通式（c1）表示的化合物（C1）的含氮有机化合物成分（C） 以及暴露后产生酸的酸产生剂组分（B），条件是化合物（C1）不在酸产生剂组分（B）中：其中RN表示可以具有取代基的含氮杂环基; X 0表示1〜10个碳原子的直链或支链的二价脂族烃基，3〜20个碳原子的环状二价脂族烃基或具有环状部分结构的3〜20个碳的二价脂肪族烃基， 这些基团中的一部分或全部氢原子被氟原子取代; M +表示有机阳离子。

    MEANS FOR TREATING MYOSIN-RELATED DISEASES
    8.
    发明申请
    MEANS FOR TREATING MYOSIN-RELATED DISEASES 审中-公开

    公开(公告)号：US20110105554A1

    公开(公告)日：2011-05-05

    申请号：US12744282

    申请日：2008-11-21

    申请人： Dietmar Manstein ,  Roman Fedorov ,  Georgios Tsiavaliaris ,  Hans-Joachim Knölker ,  René Martin ,  Juliane Kirst ,  Herwig Gutzeit ,  Markus Böhl

    发明人： Dietmar Manstein ,  Roman Fedorov ,  Georgios Tsiavaliaris ,  Hans-Joachim Knölker ,  René Martin ,  Juliane Kirst ,  Herwig Gutzeit ,  Markus Böhl

    IPC分类号： A61K31/473 ,  C07D207/30 ,  C07D333/08 ,  C07D307/02 ,  C07D209/82 ,  C07D219/04 ,  A61K31/40 ,  A61K31/381 ,  A61K31/341 ,  A61K31/403 ,  G06G7/48 ,  G01N33/566

    CPC分类号： A61K31/33 ,  C07K2299/00 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A90/26

    摘要： The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selected from (a) ranges K265-V268, V411-L441, N588-Q593, D614-T629, and V630-E646 of SEQ ID NO: 2, said myosin comprising or consisting of (i) the sequence of SEQ ID NO: 2; (ii) the sequence encoded by the sequence of SEQ ID NO: 1; (iii) a sequence being at least 40% identical to the sequence of SEQ ID NO: 2 or to the sequence encoded by the sequence of SEQ ID NO: 1; or (iv) a sequence encoded by a sequence being at least 40% identical to the sequence of SEQ ID NO: 1; wherein said sequence of (iii) or (iv) comprises said three amino acid residues, and wherein said residues comprise K265; or (b) ranges of any one of SEQ ID NOs: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106 or 108, respectively, said ranges aligning with the ranges of SEQ ID NO: 2 as defined in (a), said myosin comprising or consisting of (i) the sequence of any one of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106 or 108, respectively; (ii) the sequence encoded by the sequence of any one of SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107 or 109; respectively; (iii) a sequence being at least 40% identical to the sequence of any one of SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106 or 108, respectively, or to the sequence encoded by the sequence of any one of SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107 or 109, respectively; or (iv) a sequence encoded by a sequence being at least 40% identical to the sequence of any one of SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107 or 109, respectively; wherein said sequence of (iii) or (iv) comprises said three amino acid residues, and wherein said residues comprise the residue aligning with K265 of SEQ ID NO: 2; thereby obtaining said modulator of a myosin. Furthermore provided are a method of identifying a modulator of a myosin, pharmaceutical compositions and methods of treating cardiovascular diseases, cancer, diseases of the central nervous system, viral infections, and infections by parasites of the Apicomplexa family.

    Chemiluminescent acridinum compounds and analogues thereof as substrates of hydrolytic enzymes
    10.
    发明申请
    Chemiluminescent acridinum compounds and analogues thereof as substrates of hydrolytic enzymes 有权
    化学发光的吖啶化合物及其类似物作为水解酶的底物

    公开(公告)号：US20050032147A1

    公开(公告)日：2005-02-10

    申请号：US10928300

    申请日：2004-08-27

    申请人： Qingping Jiang ,  Anand Natrajan ,  David Sharpe ,  Wen-Jee Wong ,  Say-Jong Law

    发明人： Qingping Jiang ,  Anand Natrajan ,  David Sharpe ,  Wen-Jee Wong ,  Say-Jong Law

    IPC分类号： C07D219/04 ,  C07D491/10 ,  C07F9/64 ,  C12Q1/42 ,  C12Q1/34 ,  C07H17/02

    CPC分类号： C07D491/10 ,  C07D219/04 ,  C07F9/64 ,  C12Q1/42 ,  C12Q2334/00 ,  G01N33/533 ,  G01N33/582

    摘要： A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-P  Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.

    摘要翻译： 具有以下通式I的水解酶的化学发光底物公开如下：Lumi-MP式I其中“Lumi”是能够自身产生光的化学发光部分（a），（b）MP附着和（ c）与M连接。 Lumi的实例包括化学发光吖啶鎓化合物，苯并吖啶鎓化合物，喹啉鎓化合物，异喹啉鎓化合物，菲啶鎓化合物和光合精化合物，螺吡啶化合物，鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧，氮和硫的孤对电子的多价杂原子，其一端直接连接到Lumi的发光部分，另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。 使用上述化合物的酶反应如下：其中HE是水解酶。 Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。